Augmented phosphorylation of cardiac troponin I in hypertensive heart failure (Q35668835)

9 August 2017

Augmented phosphorylation of cardiac troponin I in hypertensive heart failure (English)

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9 August 2017

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1 reference

Xintong Dong

1

1 reference

9 August 2017

C Amelia Sumandea

2

1 reference

9 August 2017

Yi-Chen Chen

3

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9 August 2017

Mary L Garcia-Cazarin

4

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9 August 2017

Jiang Zhang

5

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9 August 2017

C William Balke

6

1 reference

9 August 2017

Marius P Sumandea

7

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9 August 2017

Ying Ge

8

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9 August 2017

language of work or name

English

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publication date

3 November 2011

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Journal of Biological Chemistry

9 August 2017

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9 August 2017

287

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9 August 2017

848-857

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9 August 2017

2

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describes a project that uses

9 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3256890/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Cardiac troponin T, a sarcomeric AKAP, tethers protein kinase A at the myofilaments

12 July 2018

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Deciphering modifications in swine cardiac troponin I by top-down high-resolution tandem mass spectrometry

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Why does troponin I have so many phosphorylation sites? Fact and fancy

12 July 2018

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Post-translational modifications of integral membrane proteins resolved by top-down Fourier transform mass spectrometry with collisionally activated dissociation

12 July 2018

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Cardiomyopathy-causing deletion K210 in cardiac troponin T alters phosphorylation propensity of sarcomeric proteins

12 July 2018

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Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I.

12 July 2018

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In vivo phosphorylation site mapping in mouse cardiac troponin I by high resolution top-down electron capture dissociation mass spectrometry: Ser22/23 are the only sites basally phosphorylated.

12 July 2018

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Back to the future: new techniques show that forgotten phosphorylation sites are present in contractile proteins of the heart whilst intensively studied sites appear to be absent

12 July 2018

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Top-down high-resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein phosphorylation state

12 July 2018

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Single amino acid sequence polymorphisms in rat cardiac troponin revealed by top-down tandem mass spectrometry

12 July 2018

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Troponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: increased or decreased?

12 July 2018

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Multiplex kinase signaling modifies cardiac function at the level of sarcomeric proteins

12 July 2018

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Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin I.

12 July 2018

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Unraveling molecular complexity of phosphorylated human cardiac troponin I by top down electron capture dissociation/electron transfer dissociation mass spectrometry

12 July 2018

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Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry.

12 July 2018

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Tackling heart failure in the twenty-first century

12 July 2018

1 reference

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The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation

12 July 2018

1 reference

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Decoding protein modifications using top-down mass spectrometry

12 July 2018

1 reference

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Global assessment of combinatorial post-translational modification of core histones in yeast using contemporary mass spectrometry. LYS4 trimethylation correlates with degree of acetylation on the same H3 tail.

12 July 2018

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G-protein coupled receptor signaling in myocardium: not for the faint of heart.

12 July 2018

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Cardiac GPCRs: GPCR signaling in healthy and failing hearts

12 July 2018

1 reference

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Extending top-down mass spectrometry to proteins with masses greater than 200 kilodaltons

12 July 2018

1 reference

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Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium.

12 July 2018

1 reference

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Regulation of cardiac contractile function by troponin I phosphorylation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C

12 July 2018

1 reference

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Molecular and integrated biology of thin filament protein phosphorylation in heart muscle

12 July 2018

1 reference

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Inhibition of PKC phosphorylation of cTnI improves cardiac performance in vivo

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Development of a strain of spontaneously hypertensive rats

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Role of troponin I phosphorylation in protein kinase C-mediated enhanced contractile performance of rat myocytes

12 July 2018

1 reference

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Kinases as therapeutic targets for heart failure

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Top-down mass spectrometry of a 29-kDa protein for characterization of any posttranslational modification to within one residue

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Studies of prevention, treatment and mechanisms of heart failure in the aging spontaneously hypertensive rat.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Increased angiotensin-I converting enzyme gene expression in the failing human heart. Quantification by competitive RNA polymerase chain reaction

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Cardiac troponin I mutants. Phosphorylation by protein kinases C and A and regulation of Ca(2+)-stimulated MgATPase of reconstituted actomyosin S-1

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Phosphorylation of the inhibitor component of troponin by phosphorylase kinase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Identification of sites phosphorylated in bovine cardiac troponin I and troponin T by protein kinase C and comparative substrate activity of synthetic peptides containing the phosphorylation sites

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Intracellular calcium transients in myocardium from spontaneously hypertensive rats during the transition to heart failure

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

The use of phosphate-affinity SDS-PAGE to measure the cardiac troponin I phosphorylation site distribution in human heart muscle.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Troponin I serines 43/45 and regulation of cardiac myofilament function

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

alpha-Adrenergic response and myofilament activity in mouse hearts lacking PKC phosphorylation sites on cardiac TnI.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Phosphorylation of troponin I controls cardiac twitch dynamics: evidence from phosphorylation site mutants expressed on a troponin I-null background in mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Top down characterization of larger proteins (45 kDa) by electron capture dissociation mass spectrometry

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Positive inotropic and negative lusitropic effect of angiotensin II: intracellular mechanisms and second messengers

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Enhanced protein phosphorylation in hypertensive hypertrophy

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

Phosphorylation of troponin I by protein kinase A accelerates relaxation and crossbridge cycle kinetics in mouse ventricular muscle

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256890

25 September 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.293258

Phosphorylation of troponin I and phospholamban during catecholamine stimulation of rabbit heart

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M111.293258

The effect of troponin I phosphorylation on the Ca2+-binding properties of the Ca2+-regulatory site of bovine cardiac troponin

21 January 2018

1 reference

12 December 2020

Protein kinase C, troponin I and heart failure: overexpressed, hyperphosphorylated and underappreciated?

1 reference

12 December 2020

The spontaneously hypertensive rat as a model of the transition from compensated left ventricular hypertrophy to failure

1 reference

12 December 2020

Up-regulation of intracellular signalling pathways may play a central pathogenic role in hypertension, atherogenesis, insulin resistance, and cancer promotion--the 'PKC syndrome'

1 reference

12 December 2020

Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure

1 reference

12 December 2020

Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure

1 reference

12 December 2020

Regulation of the isozymes of protein kinase C in the surviving rat myocardium after myocardial infarction: distinct modulation for PKC-alpha and for PKC-delta

1 reference

12 December 2020

Electron capture dissociation for structural characterization of multiply charged protein cations

1 reference

12 December 2020

Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart

1 reference

12 December 2020

Distribution and functional significance of cardiac angiotensin converting enzyme in hypertrophied rat hearts

1 reference

12 December 2020

Phosphorylation of rabbit muscle troponin and actin by a 3', 5'-c-AMP-dependent protein kinase

1 reference

12 December 2020

Beta-adrenergic receptor stimulation increases unloaded shortening velocity of skinned single ventricular myocytes from rats

1 reference

12 December 2020

PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144

1 reference

12 December 2020

Effect of angiotensin-converting enzyme inhibition on myocardial fibrosis and function in hypertrophied and failing myocardium from the spontaneously hypertensive rat

1 reference

12 December 2020

Cardiac angiotensin converting enzyme and myocardial fibrosis in the rat

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M111.293258

1 reference

9 August 2017

1 reference

9 August 2017

1 reference