Discovery of Novel Small Molecule Anti-HCV Agents via the CypA Inhibitory Mechanism Using O-Acylation-Directed Lead Optimization. (Q35656614)

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16 February 2020

title

Discovery of Novel Small Molecule Anti-HCV Agents via the CypA Inhibitory Mechanism Using O-Acylation-Directed Lead Optimization (English)

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16 February 2020

5

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16 February 2020

author name string

Wenzhong Yan

1

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16 February 2020

Jie Qing

2

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16 February 2020

Hanbing Mei

3

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16 February 2020

Fei Mao

4

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16 February 2020

Jin Zhu

6

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16 February 2020

Hualiang Jiang

7

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16 February 2020

Lei Liu

8

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16 February 2020

Linqi Zhang

9

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16 February 2020

Jian Li

10

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16 February 2020

language of work or name

English

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publication date

4 June 2015

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16 February 2020

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16 February 2020

volume

20

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16 February 2020

issue

6

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16 February 2020

page(s)

10342-10359

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Creative Commons Attribution 4.0 International

16 February 2020

copyright license

start time

4 June 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Stapled peptide-based membrane fusion inhibitors of hepatitis C virus.

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Design and synthesis of imidazo[1,2-α][1,8]naphthyridine derivatives as anti-HCV agents via direct C-H arylation

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Curing a viral infection by targeting the host: the example of cyclophilin inhibitors

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Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

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Peptidylprolyl cis/trans isomerases (immunophilins): biological diversity--targets--functions

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Structures of immunophilins and their ligand complexes

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Cyclophilin A and viral infections

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Target cell cyclophilins facilitate human papillomavirus type 16 infection

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Cyclophilin: a specific cytosolic binding protein for cyclosporin A

21 January 2018

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Sanglifehrin-cyclophilin interaction: degradation work, synthetic macrocyclic analogues, X-ray crystal structure, and binding data

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Discovering novel chemical inhibitors of human cyclophilin A: virtual screening, synthesis, and bioassay

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Strategy for discovering chemical inhibitors of human cyclophilin a: focused library design, virtual screening, chemical synthesis and bioassay

21 January 2018

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Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.

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Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes

21 January 2018

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Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In Vitro

21 January 2018

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The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication

21 January 2018

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Multiple cyclophilins involved in different cellular pathways mediate HCV replication

21 January 2018

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Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics

21 January 2018

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Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolyl cis/trans Isomerase Activity of Cyclophilins A and B

21 January 2018

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DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A

21 January 2018

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Suppression of viral RNA binding and the assembly of infectious hepatitis C virus particles in vitro by cyclophilin inhibitors

21 January 2018

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The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro

21 January 2018

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The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection

21 January 2018

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Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach

21 January 2018

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Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus

21 January 2018

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A three-dimensional model to analyze drug-drug interactions

21 January 2018

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Compensatory mutations in NS3 and NS5A proteins enhance the virus production capability of hepatitis C reporter virus

21 January 2018

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A novel luciferase and GFP dual reporter virus for rapid and convenient evaluation of hepatitis C virus replication

21 January 2018

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Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay

21 January 2018

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One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26053489

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3390/MOLECULES200610342

1 reference

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16 February 2020

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16 February 2020

PubMed publication ID

26053489

1 reference