Target deconvolution of bioactive small molecules: the heart of chemical biology and drug discovery (Q35652038)

9 August 2017

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title

Target deconvolution of bioactive small molecules: the heart of chemical biology and drug discovery (English)

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9 August 2017

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Hye Jin Jung

1

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PubMed ID

26040984

9 August 2017

Ho Jeong Kwon

series ordinal

2

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9 August 2017

4 June 2015

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Archives of Pharmacal Research

9 August 2017

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9 August 2017

38

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9 August 2017

9

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9 August 2017

1627-1641

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https://scigraph.springernature.com/pub.10.1007/s12272-015-0618-3

9 August 2017

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Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis

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The intermediate filament protein vimentin is a new target for epigallocatechin gallate

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Identification and validation of calmodulin as a binding protein of an anti-proliferative small molecule 3,4-dihydroisoquinolinium salt.

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21 January 2018

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Discovery of new small molecules and targets towards angiogenesis via chemical genomics approach

21 January 2018

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Mass spectrometry-based proteomics turns quantitative

21 January 2018

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Identifying the proteins to which small-molecule probes and drugs bind in cells

21 January 2018

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Discovery and target identification of an antiproliferative agent in live cells using fluorescence difference in two-dimensional gel electrophoresis.

21 January 2018

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Phage display systems and their applications

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures.

21 January 2018

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Quality, not quantity: the role of natural products and chemical proteomics in modern drug discovery

21 January 2018

1 reference

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Rapid identification of a protein binding partner for the marine natural product kahalalide F by using reverse chemical proteomics.

21 January 2018

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Applications of Connectivity Map in drug discovery and development

21 January 2018

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Bugs, drugs and chemical genomics

21 January 2018

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Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents

21 January 2018

1 reference

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Development and application of high-performance affinity beads: toward chemical biology and drug discovery

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Biochemical target isolation for novices: affinity-based strategies

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The cloning of human genes using cDNA phage display and small-molecule chemical probes

21 January 2018

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Target identification and mechanism of action in chemical biology and drug discovery

21 January 2018

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Bioinformatic analysis of proteomics data

21 January 2018

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Chemical genetics resulting from a passion for synthetic organic chemistry.

21 January 2018

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A new curcumin derivative, HBC, interferes with the cell cycle progression of colon cancer cells via antagonization of the Ca2+/calmodulin function

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Patient-derived tumor xenografts: transforming clinical samples into mouse models

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Proteomic methods for drug target discovery

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Exploring biology with small organic molecules

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DTome: a web-based tool for drug-target interactome construction

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How were new medicines discovered?

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StableIsotope Labeling with Amino Acids in Cell Culture (SILAC)-based strategy for proteome-wide thermodynamic analysis of protein-ligand binding interactions

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Using transcriptome sequencing to identify mechanisms of drug action and resistance

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Predicting drug-target interactions using restricted Boltzmann machines

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Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP).

21 January 2018

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Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition

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Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements.

21 January 2018

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Novel pathway compendium analysis elucidates mechanism of pro-angiogenic synthetic small molecule

21 January 2018

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Novel computational approaches to polypharmacology as a means to define responses to individual drugs

21 January 2018

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Prediction of drug-target interaction networks from the integration of chemical and genomic spaces.

21 January 2018

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FR177391, a new anti-hyperlipidemic agent from Serratia. IV. Target identification and validation by chemical genetic approaches

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New insights into chemical biology from ORFeome libraries

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Target identification for small bioactive molecules: finding the needle in the haystack

21 January 2018

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 January 2018

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21 January 2018

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10.1007/S12272-015-0618-3

21 January 2018

Identifiers

DOI

1 reference

9 August 2017

1 reference

PubMed ID

26040984