Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs. (Q35646690)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22228937%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs (English)

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19 January 2020

1 reference

2

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19 January 2020

author name string

Supriya Baikar

series ordinal

1

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19 January 2020

language of work or name

English

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publication date

1 January 2010

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19 January 2020

published in

Pharmacognosy Reviews

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19 January 2020

volume

4

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19 January 2020

issue

7

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19 January 2020

page(s)

12-26

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A review on plant-derived natural products and their analogs with anti-tumor activity

19 January 2020

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Lunacridine from Lunasia amara is a DNA intercalating topoisomerase II inhibitor

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ABC transporters involved in the transport of plant secondary metabolites

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Engineering of secondary metabolite pathways

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Flavonoids as anticancer agents: structure-activity relationship study

27 July 2018

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Engineering secondary metabolite production in plants.

27 July 2018

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Flavonoids: a review of probable mechanisms of action and potential applications

27 July 2018

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DNA topoisomerases: structure, function, and mechanism

27 July 2018

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The molecular biology of cancer

27 July 2018

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Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase

27 July 2018

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Topoisomerase I poisons and suppressors as anticancer drugs

27 July 2018

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Flavonoids and isoflavonoids - a gold mine for metabolic engineering.

27 July 2018

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Legumes and soybeans: overview of their nutritional profiles and health effects

27 July 2018

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Structure of DNA topoisomerases

27 July 2018

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Discovery of podophyllotoxins

27 July 2018

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Mammalian DNA topoisomerase IIIalpha is essential in early embryogenesis

27 July 2018

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Glycosylated flavones as selective inhibitors of topoisomerase IV.

27 July 2018

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An atypical topoisomerase II from Archaea with implications for meiotic recombination

27 July 2018

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DNA topoisomerases: essential enzymes and lethal targets

27 July 2018

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Structure and function of type II DNA topoisomerases

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Interaction between DNA and an Escherichia coli protein omega

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase

27 July 2018

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New topoisomerase essential for chromosome segregation in E. coli.

27 July 2018

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The chemical and biological route from podophyllotoxin glucoside to etoposide: ninth Cain memorial Award lecture

27 July 2018

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27 July 2018

The chemistry of taxol

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Induction of topoisomerase II-mediated DNA cleavage by the plant naphthoquinones plumbagin and shikonin

27 July 2018

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Purification and characterization of DNA topoisomerase IV in Escherichia coli

27 July 2018

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Identification of the yeast TOP3 gene product as a single strand-specific DNA topoisomerase

27 July 2018

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Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives

27 July 2018

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Interaction between DNA and Escherichia coli protein omega. Formation of a complex between single-stranded DNA and omega protein

27 July 2018

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T4 DNA-delay proteins, required for specific DNA replication, form a complex that has ATP-dependent DNA topoisomerase activity

27 July 2018

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T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication

27 July 2018

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DNA gyrase: an enzyme that introduces superhelical turns into DNA

27 July 2018

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Studies on cytotoxic, hydroxyl radical scavenging and topoisomerase inhibitory activities of extracts of Tabernaemontana divaricata (L.) R.Br. ex Roem. and Schult

27 July 2018

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Plant-derived natural product research aimed at new drug discovery

25 September 2018

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Topoisomerase I inhibition and cytotoxicity of licochalcones A and E from Glycyrrhiza inflata

25 September 2018

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Topoisomerase II inhibition and high yield of endoreduplication induced by the flavonoids luteolin and quercetin.

25 September 2018

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Nepalensinols D-G, new resveratrol oligomers from Kobresia nepalensis (Cyperaceae) as potent inhibitors of DNA topoisomerase II.

25 September 2018

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Inhibition of cellular proliferation by diterpenes, topoisomerase II inhibitor.

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Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases and induces apoptosis of cancer cells

25 September 2018

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Plant cell factories in the post-genomic era: new ways to produce designer secondary metabolites

25 September 2018

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Isodiospyrin as a novel human DNA topoisomerase I inhibitor.

25 September 2018

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An in vitro evaluation of human DNA topoisomerase I inhibition by Peganum harmala L. seeds extract and its beta-carboline alkaloids.

25 September 2018

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Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I.

25 September 2018

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Antitumor properties of podophyllotoxin and related compounds

25 September 2018

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Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors.

25 September 2018

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Topoisomerase I Inhibitors.

25 September 2018

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Diversity of DNA topoisomerases I and inhibitors.

25 September 2018

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DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia

25 September 2018

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DNA topoisomerase V is a relative of eukaryotic topoisomerase I from a hyperthermophilic prokaryote

25 September 2018

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Inhibition of topoisomerase I function by nitidine and fagaronine

25 September 2018

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Interactions of combretastatin, a new plant-derived antimitotic agent, with tubulin.

25 September 2018

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Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

25 September 2018

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12 December 2020

Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I

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12 December 2020

Escherichia coli DNA topoisomerase III: purification and characterization of a new type I enzyme

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DNA topoisomerase I inhibitors: cytotoxic flavones from Lethedon tannaensis

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12 December 2020

Biological activity of diospyrin towards Ehrlich ascites carcinoma in Swiss A mice

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12 December 2020

Can Arabidopsis make complex alkaloids?

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12 December 2020

Novel mechanisms of DNA topoisomerase II inhibition by pyranonaphthoquinone derivatives-eleutherin, alpha lapachone, and beta lapachone

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12 December 2020

Purification of a DNA topoisomerase II from the hyperthermophilic archaeon Sulfolobus shibatae. A thermostable enzyme with both bacterial and eucaryal features

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12 December 2020

Salvicine, a novel DNA topoisomerase II inhibitor, exerting its effects by trapping enzyme-DNA cleavage complexes

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12 December 2020

Antitumor activity of a novel podophyllotoxin derivative (TOP-53) against lung cancer and lung metastatic cancer

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12 December 2020

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12 December 2020

Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents

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12 December 2020

Investigating the biological functions of DNA topoisomerases in eukaryotic cells

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12 December 2020

Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

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12 December 2020

Fomitellic acids, triterpenoid inhibitors of eukaryotic DNA polymerases from a basidiomycete, Fomitella fraxinea

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12 December 2020

Catalytic inhibitors of DNA topoisomerase II

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12 December 2020

Diospyrin, a bisnaphthoquinone: a novel inhibitor of type I DNA topoisomerase of Leishmania donovani

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12 December 2020

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

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12 December 2020

Isolation and structure of combretastatin

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.1139/V82-202

Identifiers

DOI

10.4103/0973-7847.65320

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22228937%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22228937%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference