Regulation of TRPML1 function (Q35640908)

9 August 2017

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title

Regulation of TRPML1 function (English)

1 reference

9 August 2017

Helen Waller-Evans

1

1 reference

PubMed ID

26009188

9 August 2017

Emyr Lloyd-Evans

series ordinal

2

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9 August 2017

1 June 2015

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Biochemical Society Transactions

9 August 2017

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9 August 2017

43

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9 August 2017

442-446

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9 August 2017

3

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TRP-ML1 is a lysosomal monovalent cation channel that undergoes proteolytic cleavage

9 August 2017

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Cloning of the gene encoding a novel integral membrane protein, mucolipidin-and identification of the two major founder mutations causing mucolipidosis type IV

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Identification of the gene causing mucolipidosis type IV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Cultured skin fibroblasts derived from patients with mucolipidosis 4 are auto-fluorescent

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Abnormal transport along the lysosomal pathway in mucolipidosis, type IV disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

TRPMLs: in sickness and in health

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Roles of CUP-5, the Caenorhabditis elegans orthologue of human TRPML1, in lysosome and gut granule biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Identification and characterization of the single channel function of human mucolipin-1 implicated in mucolipidosis type IV, a disorder affecting the lysosomal pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Molecular pathophysiology of mucolipidosis type IV: pH dysregulation of the mucolipin-1 cation channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

The calcium channel mucolipin-3 is a novel regulator of trafficking along the endosomal pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Zinc dyshomeostasis is linked with the loss of mucolipidosis IV-associated TRPML1 ion channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Phosphatidylinositol-3,5-bisphosphate: no longer the poor PIP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Drosophila TRPML forms PI(3,5)P2-activated cation channels in both endolysosomes and plasma membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

TRP-ML1 functions as a lysosomal NAADP-sensitive Ca2+ release channel in coronary arterial myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

NAADP-induced Ca(2+ signaling in response to endothelin is via the receptor subtype B and requires the integrity of lipid rafts/caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Reconstitution of lysosomal NAADP-TRP-ML1 signaling pathway and its function in TRP-ML1(-/-) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

NAADP mobilizes calcium from acidic organelles through two-pore channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Small molecule activators of TRPML3

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Differential mechanisms of action of the mucolipin synthetic agonist, ML-SA1, on insect TRPML and mammalian TRPML1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Bone marrow-derived mesenchymal stem cells prevent the loss of Niemann-Pick type C mouse Purkinje neurons by correcting sphingolipid metabolism and increasing sphingosine-1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

The stimulation of adenosine A2A receptors ameliorates the pathological phenotype of fibroblasts from Niemann-Pick type C patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Deregulation of sphingolipid metabolism in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

Functional links between mucolipin-1 and Ca2+-dependent membrane trafficking in mucolipidosis IV

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140311

21 January 2018

Identifiers

DOI

10.1042/BST20140311

1 reference

9 August 2017

1 reference

PubMed ID

26009188