APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability (Q35629330)

9 August 2017

APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability (English)

1 reference

Amyloid-beta-like protein CELE_C42D8.8

9 August 2017

Caenorhabditis elegans

0 references

1 reference

GOA release 2020-03-11

author name string

Angela Hornsten

1

1 reference

9 August 2017

Jason Lieberthal

2

1 reference

9 August 2017

Shruti Fadia

3

1 reference

9 August 2017

Richard Malins

4

1 reference

9 August 2017

Lawrence Ha

5

1 reference

9 August 2017

Xiaomeng Xu

6

1 reference

9 August 2017

Isabelle Daigle

7

1 reference

9 August 2017

Mindy Markowitz

8

1 reference

9 August 2017

Gregory O'Connor

9

1 reference

9 August 2017

Ronald Plasterk

10

1 reference

9 August 2017

Chris Li

11

1 reference

9 August 2017

language of work or name

English

0 references

publication date

31 January 2007

1 reference

Proceedings of the National Academy of Sciences of the United States of America

9 August 2017

1 reference

9 August 2017

104

1 reference

9 August 2017

1971-1976

1 reference

9 August 2017

6

1 reference

The amyloid-beta precursor protein: integrating structure with biological function

9 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Amyloid precursor protein interacts with notch receptors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

APP induces neuronal apoptosis through APP-BP1-mediated downregulation of beta-catenin

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Identity and function of γ‐secretase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Do disorders of movement cause movement disorders and dementia?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Binding partners of Alzheimer's disease proteins: are they physiologically relevant?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Target-selected gene inactivation in Caenorhabditis elegans by using a frozen transposon insertion mutant bank

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

The genetics of Caenorhabditis elegans

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Amyloid plaque core protein in Alzheimer disease and Down syndrome

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

The Caenorhabditis elegans rol-6 gene, which interacts with the sqt-1 collagen gene to determine organismal morphology, encodes a collagen

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

What the evolution of the amyloid protein precursor supergene family tells us about its function

27 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603997104

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603997104

Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603997104

Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603997104

Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603997104

Effects of PS1 deficiency on membrane protein trafficking in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603997104

The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603997104

The life cycle of the nematode Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603997104

feh-1 and apl-1, the Caenorhabditis elegans orthologues of mammalian Fe65 and beta-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumping.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Genetic control of programmed cell death in the nematode Caenorhabditis elegans.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Synaptic transmission deficits in Caenorhabditis elegans synaptobrevin mutants.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

The Caenorhabditis elegans heterochronic gene pathway controls stage-specific transcription of collagen genes.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794273

25 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603997104

Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17267616

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0603997104

1 reference

9 August 2017

0 references

1 reference

9 August 2017

1 reference