IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes (Q35626298)

9 August 2017

IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes (English)

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9 August 2017

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Gaetana Restivo

1

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9 August 2017

Bach-Cuc Nguyen

2

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9 August 2017

Piotr Dziunycz

3

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9 August 2017

Elodie Ristorcelli

4

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9 August 2017

Russell J H Ryan

5

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9 August 2017

Özden Yalçin Özuysal

6

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9 August 2017

Matteo Di Piazza

7

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9 August 2017

Freddy Radtke

8

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9 August 2017

Michael J Dixon

9

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9 August 2017

Günther F L Hofbauer

10

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9 August 2017

Karine Lefort

11

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9 August 2017

G Paolo Dotto

12

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9 August 2017

language of work or name

English

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publication date

1 November 2011

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9 August 2017

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9 August 2017

30

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9 August 2017

22

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9 August 2017

4571-4585

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A role for the primary cilium in Notch signaling and epidermal differentiation during skin development

9 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Opposing roles for calcineurin and ATF3 in squamous skin cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

The canonical Notch signaling pathway: unfolding the activation mechanism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Rational targeting of Notch signaling in cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Notch tumor suppressor function

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

IRF6 in development and disease: a mediator of quiescence and differentiation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Epidermal Notch signalling: differentiation, cancer and adhesion

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

The IRF family transcription factors in immunity and oncogenesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

p63 regulates proliferation and differentiation of developmentally mature keratinocytes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Canonical notch signaling functions as a commitment switch in the epidermal lineage

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6)

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Notch signalling: a simple pathway becomes complex

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

p63 and the epithelial stem cell: more than status quo?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

p63: Molecular complexity in development and cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

The role of p63 in development and differentiation of the epidermis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Notch1 functions as a tumor suppressor in mouse skin

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Structure and function of IRF-7.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

IRF family of transcription factors as regulators of host defense

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Switch from p53 to MDM2 as differentiating human keratinocytes lose their proliferative potential and increase in cellular size

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Notch signalling via RBP-J promotes myeloid differentiation.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Notch signaling: cell fate control and signal integration in development

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner

27 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.325

NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.325

Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.325

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.325

HES and HERP families: multiple effectors of the Notch signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.325

CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.325

Asymmetric cell divisions promote Notch-dependent epidermal differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.325

Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.325

Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.325

Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression

25 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.325

Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243593

Crosstalk of Notch with p53 and p63 in cancer growth control

15 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21909072

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2011.325

1 reference

9 August 2017

1 reference

9 August 2017

1 reference