Peroxisome-proliferator-activated receptors and cancers: complex stories (Q35621403)

9 August 2017

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title

Peroxisome-proliferator-activated receptors and cancers: complex stories (English)

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9 August 2017

2

Béatrice Desvergne

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author name string

Liliane Michalik

series ordinal

1

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9 August 2017

Walter Wahli

series ordinal

3

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9 August 2017

language of work or name

English

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publication date

1 January 2004

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9 August 2017

published in

Nature Reviews Cancer

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9 August 2017

volume

4

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9 August 2017

issue

1

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9 August 2017

page(s)

61-70

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A unified nomenclature system for the nuclear receptor superfamily

9 August 2017

cites work

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Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription

31 March 2020

1 reference

Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator

31 March 2020

1 reference

Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms

31 March 2020

1 reference

The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling

31 March 2020

1 reference

Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein

31 March 2020

1 reference

Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway.

31 March 2020

1 reference

Peroxisome proliferator-activated receptors beta/delta: emerging roles for a previously neglected third family member

31 March 2020

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Biochemical mechanisms of induction of hepatic peroxisome proliferation

31 March 2020

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Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643

31 March 2020

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Central role of PPARalpha in the mechanism of action of hepatocarcinogenic peroxisome proliferators

31 March 2020

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Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease

31 March 2020

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Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

31 March 2020

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Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

31 March 2020

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Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643.

31 March 2020

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Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone.

31 March 2020

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Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver.

31 March 2020

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Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin

31 March 2020

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Effect of three tumour promoters on the stability of hepatocyte cultures and apoptosis after transforming growth factor-beta 1.

31 March 2020

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The non-genotoxic hepatocarcinogen nafenopin suppresses rodent hepatocyte apoptosis induced by TGFbeta1, DNA damage and Fas.

31 March 2020

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The rodent non-genotoxic hepatocarcinogen nafenopin suppresses apoptosis preferentially in non-cycling hepatocytes but also elevates CDK4, a cell cycle progression factor.

31 March 2020

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Non-genotoxic hepatocarcinogenesis: suppression of apoptosis by peroxisome proliferators

31 March 2020

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Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha).

31 March 2020

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Oxidative DNA damage caused by persistent peroxisome proliferation: its role in hepatocarcinogenesis

31 March 2020

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Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis

31 March 2020

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Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators

31 March 2020

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Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis

31 March 2020

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Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans?

31 March 2020

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Hepatic peroxisome proliferation in rodents and its significance for humans

31 March 2020

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Peroxisome proliferator activated receptor-alpha expression in human liver.

31 March 2020

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Peroxisome proliferator-activated receptors: structures and function

31 March 2020

2 references

31 March 2020

inferred from DOI database lookup

7 January 2021

based on heuristic

trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals

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The peroxisome proliferator (PP) response element upstream of the human acyl CoA oxidase gene is inactive among a sample human population: significance for species differences in response to PPs.

31 March 2020

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Species differences in sequence and activity of the peroxisome proliferator response element (PPRE) within the acyl CoA oxidase gene promoter

31 March 2020

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The in vitro hydrolysis of some phthalate diesters by hepatic and intestinal preparations from various species

31 March 2020

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A biomarker approach to measuring human dietary exposure to certain phthalate diesters

31 March 2020

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Differentiation and reversal of malignant changes in colon cancer through PPARgamma

31 March 2020

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Peroxisome proliferator-activated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice

31 March 2020

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Activators of the nuclear receptor PPARgamma enhance colon polyp formation

31 March 2020

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Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

31 March 2020

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Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice

31 March 2020

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APC-dependent suppression of colon carcinogenesis by PPARgamma

31 March 2020

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PPARgamma ligands: taking Ppart in chemoprevention

31 March 2020

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Terminal differentiation of human breast cancer through PPAR gamma

31 March 2020

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Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice

31 March 2020

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A ligand of peroxisome proliferator-activated receptor gamma, retinoids, and prevention of preneoplastic mammary lesions

31 March 2020

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15-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells

31 March 2020

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Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer

31 March 2020

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Peroxisome proliferator-activated receptor gamma is frequently downregulated in a diversity of sporadic nonmedullary thyroid carcinomas

31 March 2020

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PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A.

31 March 2020

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Peroxisome proliferator activated receptor gamma, CCAAT/enhancer-binding protein alpha, and cell cycle status regulate the commitment to adipocyte differentiation

31 March 2020

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PPAR-gamma receptor ligands: novel therapy for pituitary adenomas

31 March 2020

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Role of PPARgamma in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18(INK4c) and p21(Waf1/Cip1), during adipogenesis

31 March 2020

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Early de novo gene expression is required for 15-deoxy-Delta 12,14-prostaglandin J2-induced apoptosis in breast cancer cells

31 March 2020

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PPARgamma agonists inhibit cell growth and suppress the expression of cyclin D1 and EGF-like growth factors in ras-transformed rat intestinal epithelial cells

31 March 2020

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Peroxisome proliferator-activated receptor gamma reduces the growth rate of pancreatic cancer cells through the reduction of cyclin D1.

31 March 2020

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Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin D1.

31 March 2020

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Target genes of peroxisome proliferator-activated receptor gamma in colorectal cancer cells

31 March 2020

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Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22.

31 March 2020

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Apoptosis induced by activation of peroxisome-proliferator activated receptor-gamma is associated with Bcl-2 and NF-kappaB in human colon cancer

31 March 2020

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Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells

31 March 2020

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Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.

31 March 2020

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Activation of PPARgamma increases PTEN expression in pancreatic cancer cells

31 March 2020

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Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo

31 March 2020

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Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.

31 March 2020

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Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma

31 March 2020

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Expression of peroxisome proliferator activated receptor-gamma in non-small cell lung carcinoma: correlation with histological type and grade

31 March 2020

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Controversy: PPARgamma as a target for treatment of colorectal cancer

31 March 2020

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Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

31 March 2020

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Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

31 March 2020

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Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors

31 March 2020

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Peroxisome proliferators and retinoids affect JEG-3 choriocarcinoma cell function

31 March 2020

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The human peroxisome proliferator-activated receptor (PPAR) subtype NUC1 represses the activation of hPPAR alpha and thyroid hormone receptors

31 March 2020

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PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs

31 March 2020

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Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer

31 March 2020

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Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells

31 March 2020

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Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer

31 March 2020

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Correlation of expression of cyclooxygenase-2, vascular endothelial growth factor, and peroxisome proliferator-activated receptor delta with head and neck squamous cell carcinoma

31 March 2020

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Heightened expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-delta in human endometrial adenocarcinoma

31 March 2020

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Peroxisome proliferator-activated receptor beta expression in human breast epithelial cell lines of tumorigenic and non-tumorigenic origin

31 March 2020

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Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice

31 March 2020

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Critical roles of PPAR beta/delta in keratinocyte response to inflammation

31 March 2020

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Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)

31 March 2020

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Peroxisome proliferator-activated receptor delta activation promotes cell survival following hypertonic stress

31 March 2020

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Prostacyclin-dependent apoptosis mediated by PPAR delta

31 March 2020

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Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells.

31 March 2020

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Peroxisome proliferator-activated receptor delta is up-regulated during vascular lesion formation and promotes post-confluent cell proliferation in vascular smooth muscle cells

31 March 2020

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The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages

31 March 2020

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PPAR delta agonists stimulate oligodendrocyte differentiation in tissue culture

31 March 2020

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31 March 2020

Peroxisome biogenesis

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Roles of PPARs in health and disease.

31 March 2020

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A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

31 March 2020

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Obesity associated with a mutation in a genetic regulator of adipocyte differentiation

31 March 2020

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Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

31 March 2020

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Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity.

31 March 2020

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Loss-of-Function Mutations in PPARγ Associated with Human Colon Cancer

31 March 2020

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PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected]

31 March 2020

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RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma.

31 March 2020

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Detection of the PAX8-PPAR gamma fusion oncogene in both follicular thyroid carcinomas and adenomas.

31 March 2020

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Activation of PPARgamma leads to inhibition of anchorage-independent growth of human colorectal cancer cells

31 March 2020

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Involvement of p21(WAF1/Cip1), p27(Kip1), and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines

31 March 2020

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Peroxisome proliferator-activated receptor gamma ligands inhibit retinoblastoma phosphorylation and G1--> S transition in vascular smooth muscle cells

31 March 2020

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Activation of PPARgamma inhibits cell growth and induces apoptosis in human gastric cancer cells

31 March 2020

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PPAR γ activators induce growth arrest and process extension in B12 oligodendrocyte‐like cells and terminal differentiation of cultured oligodendrocytes

31 March 2020

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PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL

31 March 2020

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Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells

31 March 2020

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Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages

31 March 2020

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Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-Delta(12,14)(12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells

31 March 2020

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A ligand for peroxisome proliferator activated receptor gamma inhibits cell growth and induces apoptosis in human liver cancer cells

31 March 2020

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15-Deoxy-Delta(12,14)-prostaglandin J(2), a ligand for peroxisome proliferator-activated receptor-gamma, induces apoptosis in JEG3 choriocarcinoma cells

31 March 2020

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Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1254

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9 August 2017

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