Pharmacokinetics and pharmacodynamics of clofazimine in a mouse model of tuberculosis (Q35607808)

9 August 2017

title

Pharmacokinetics and pharmacodynamics of clofazimine in a mouse model of tuberculosis (English)

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9 August 2017

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12

Jacques H Grosset

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9 August 2017

Rosemary V Swanson

1

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9 August 2017

John Adamson

2

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9 August 2017

Chivonne Moodley

3

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9 August 2017

Bongani Ngcobo

4

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9 August 2017

Nicole C Ammerman

5

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9 August 2017

Afton Dorasamy

6

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9 August 2017

Sashen Moodley

7

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9 August 2017

Zinhle Mgaga

8

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9 August 2017

Asa Tapley

9

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9 August 2017

Linda A Bester

10

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9 August 2017

Sanil Singh

11

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9 August 2017

Deepak V Almeida

13

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9 August 2017

language of work or name

English

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publication date

9 March 2015

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Antimicrobial Agents and Chemotherapy

9 August 2017

published in

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9 August 2017

volume

59

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9 August 2017

issue

6

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9 August 2017

page(s)

3042-3051

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Clofazimine shortens the duration of the first-line treatment regimen for experimental chemotherapy of tuberculosis

9 August 2017

cites work

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Limited activity of clofazimine as a single drug in a mouse model of tuberculosis exhibiting caseous necrotic granulomas

27 July 2018

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Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism.

27 July 2018

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Assessment of clofazimine activity in a second-line regimen for tuberculosis in mice.

27 July 2018

1 reference

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Randomized dose-ranging study of the 14-day early bactericidal activity of bedaquiline (TMC207) in patients with sputum microscopy smear-positive pulmonary tuberculosis

27 July 2018

1 reference

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Multiscale distribution and bioaccumulation analysis of clofazimine reveals a massive immune system-mediated xenobiotic sequestration response

27 July 2018

1 reference

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Macrophages sequester clofazimine in an intracellular liquid crystal-like supramolecular organization

27 July 2018

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Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide

27 July 2018

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Sterilizing activities of novel combinations lacking first- and second-line drugs in a murine model of tuberculosis

27 July 2018

1 reference

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Mouse model of necrotic tuberculosis granulomas develops hypoxic lesions

27 July 2018

1 reference

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Pharmacokinetics and pharmacodynamics of TMC207 and its N-desmethyl metabolite in a murine model of tuberculosis

27 July 2018

1 reference

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Sterilizing activity of novel TMC207- and PA-824-containing regimens in a murine model of tuberculosis

27 July 2018

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Reduction of clofazimine by mycobacterial type 2 NADH:quinone oxidoreductase: a pathway for the generation of bactericidal levels of reactive oxygen species

27 July 2018

1 reference

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Bactericidal activity of the diarylquinoline TMC207 against Mycobacterium tuberculosis outside and within cells

27 July 2018

1 reference

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Short, highly effective, and inexpensive standardized treatment of multidrug-resistant tuberculosis

27 July 2018

1 reference

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Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis

27 July 2018

1 reference

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A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis

27 July 2018

1 reference

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Comparative pharmacokinetics and pharmacodynamics of the rifamycin antibacterials

27 July 2018

1 reference

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The antileprosy agent B.663 (Clofazimine) and the reticuloendothelial system

27 July 2018

1 reference

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Tissue concentrations of clofazimine (B663) in man.

27 July 2018

1 reference

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Some observations on the pharmacology of clofazimine (B663).

27 July 2018

1 reference

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Electron microscope studies of the antileprosy drug B663 (clofazimine; Lamprenel).

27 July 2018

1 reference

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Microdialysis sampling for determination of plasma protein binding of drugs

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432183

Bactericidal activity of pyrazinamide and clofazimine alone and in combinations with pretomanid and bedaquiline

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432183

Cross-resistance between clofazimine and bedaquiline through upregulation of MmpL5 in Mycobacterium tuberculosis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432183

Ipr1 gene mediates innate immunity to tuberculosis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432183

Chemotherapy of murine leprosy. IV. The effects of amithiozone (TB1/698), p-aminosalicylic acid (PAS), B 283 (a phenazine pigment), five antibiotics and three diphenylthiourea compounds on mouse leprosy

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432183

WHO Expert Committee on Leprosy

25 September 2018

1 reference

12 December 2020

Antituberculosis activity in the phenazine series; isomeric pigments obtained by oxidation of o-phenylenediamine derivatives

1 reference

12 December 2020

A New Series of Phenazines (Rimino-Compounds) With High Antituberculosis Activity

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12 December 2020

Pharmacologic Studies of Clofazimine *

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12 December 2020

Identifiers

DOI

10.1128/AAC.00260-15

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9 August 2017

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9 August 2017

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