Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes. (Q35606917)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16399079%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16399079%20AND%20SRC:MED&resulttype=core&format=json

V-crk avian sarcoma virus CT10 oncogene homolog-like

15 January 2020

main subject

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Fibroblast growth factor receptor 1

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Fibroblast growth factor receptor 2

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Fibroblast growth factor 8

1 reference

author

Jennetta W Hammond

5

1 reference

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15 January 2020

author name string

Anne M Moon

1

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15 January 2020

Deborah L Guris

2

1 reference

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15 January 2020

Ji-heui Seo

3

1 reference

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15 January 2020

Leiming Li

4

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15 January 2020

Amy Talbot

6

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15 January 2020

Akira Imamoto

7

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15 January 2020

language of work or name

English

0 references

publication date

1 January 2006

1 reference

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15 January 2020

number of pages

10

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inferred from page(s)

published in

Developmental Cell

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15 January 2020

volume

10

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15 January 2020

page(s)

71-80

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15 January 2020

issue

1

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Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome

15 January 2020

cites work

1 reference

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Loss of Gbx2 results in neural crest cell patterning and pharyngeal arch artery defects in the mouse embryo

12 July 2018

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Mechanisms underlying differential responses to FGF signaling

12 July 2018

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12 July 2018

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12 July 2018

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The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth

12 July 2018

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Promotion and attenuation of FGF signaling through the Ras-MAPK pathway

12 July 2018

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Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction

12 July 2018

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Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development

12 July 2018

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Role of TBX1 in human del22q11.2 syndrome

12 July 2018

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

12 July 2018

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Unraveling the genetic and developmental mysteries of 22q11 deletion syndrome

12 July 2018

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Spatial and temporal patterns of ERK signaling during mouse embryogenesis

12 July 2018

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12 July 2018

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Translocation of CrkL to focal adhesions mediates integrin-induced migration downstream of Src family kinases

12 July 2018

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Fgfr1 regulates patterning of the pharyngeal region

12 July 2018

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An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome

12 July 2018

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Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways

12 July 2018

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The anterior heart-forming field: voyage to the arterial pole of the heart

12 July 2018

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Focal adhesions require catalytic activity of Src family kinases to mediate integrin-matrix adhesion

12 July 2018

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Chromosomal microdeletions: dissecting del22q11 syndrome

12 July 2018

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Crk family adaptors-signalling complex formation and biological roles

12 July 2018

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The 22q11.2 deletion syndrome

12 July 2018

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Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways

12 July 2018

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Fibroblast growth factors

12 July 2018

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Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome

12 July 2018

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DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1

12 July 2018

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Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice

12 July 2018

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TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome

12 July 2018

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Fgf8 is required for outgrowth and patterning of the limbs

12 July 2018

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The 22q11 deletion syndromes

12 July 2018

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Cortical dysgenesis in 2 patients with chromosome 22q11 deletion

12 July 2018

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Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development

12 July 2018

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12 July 2018

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12 July 2018

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Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch

12 July 2018

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Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity

12 July 2018

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Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk

12 July 2018

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Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo

12 July 2018

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Regulation of Smad signalling by protein associations and signalling crosstalk

12 July 2018

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Physiological signals and oncogenesis mediated through Crk family adapter proteins

12 July 2018

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Fgf10 is essential for limb and lung formation

12 July 2018

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Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless

12 July 2018

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Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

12 July 2018

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Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development

12 July 2018

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Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning

12 July 2018

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An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

12 July 2018

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Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction

12 July 2018

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TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes

12 July 2018

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A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

12 July 2018

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Fibroblast growth factor receptor-1 (FGFR-1) is essential for normal neural tube and limb development.

12 July 2018

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Receptor specificity of the fibroblast growth factor family

12 July 2018

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Developmental expression of two murine fibroblast growth factor receptors, flg and bek

12 July 2018

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Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse

12 July 2018

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FGF signal interpretation is directed by Sprouty and Spred proteins during mesoderm formation

12 July 2018

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Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse.

25 September 2018

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Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors.

25 September 2018

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Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse.

25 September 2018

1 reference

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A genetic link between Tbx1 and fibroblast growth factor signaling.

25 September 2018

1 reference

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FGF signaling regulates expression of Tbx2, Erm, Pea3, and Pax3 in the early nasal region.

25 September 2018

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Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signaling during early zebrafish development.

25 September 2018

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Zebrafish pea3 and erm are general targets of FGF8 signaling.

25 September 2018

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Expression of members of the Fgf family and their receptors during midfacial development.

25 September 2018

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Fgf8 signalling from the AER is essential for normal limb development.

25 September 2018

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FGF signaling in mouse gastrulation and anteroposterior patterning.

25 September 2018

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Variable phenotypes in velocardiofacial syndrome with chromosomal deletion.

25 September 2018

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Expression of the fibroblast growth factor receptor FGFR-1/flg during gastrulation and segmentation in the mouse embryo

25 September 2018

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12 December 2020

Murine FGFR-1 is required for early postimplantation growth and axial organization

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12 December 2020

The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades

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12 December 2020

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Signal transduction by fibroblast growth factor receptors

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12 December 2020

Modulation of Fgf8 activity during vertebrate brain development

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Deconstructing DiGeorge syndrome

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12 December 2020

Recovery from arterial growth delay reduces penetrance of cardiovascular defects in mice deleted for the DiGeorge syndrome region

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12 December 2020

10.1016/J.DEVCEL.2005.12.003

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16399079%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16399079%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference