Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases. (Q35535825)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21782895%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

review article

1 reference

title

Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21782895%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

Stefanie Prast-Nielsen

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21782895%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

Hsin-Hung Huang

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21782895%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

David L Williams

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21782895%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

language of work or name

English

0 references

publication date

14 July 2011

1 reference

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Biochimica et Biophysica Acta

8 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21782895%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

1810

1 reference

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8 February 2020

issue

12

1 reference

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8 February 2020

page(s)

1262-1271

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21782895%20AND%20SRC:MED&resulttype=core&format=json

Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni

8 February 2020

cites work

1 reference

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Linked thioredoxin-glutathione systems in platyhelminth parasites: alternative pathways for glutathione reduction and deglutathionylation.

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Differing views of the role of selenium in thioredoxin reductase

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Thioredoxin and glutathione systems differ in parasitic and free-living platyhelminths

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CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes

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Parasites and poverty: the case of schistosomiasis

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Redox regulation of transcriptional activity of retinoic acid receptor by thioredoxin glutathione reductase (TGR).

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Characterization of the methionine sulfoxide reductases of Schistosoma mansoni

12 July 2018

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12 July 2018

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Focus on mammalian thioredoxin reductases--important selenoproteins with versatile functions

12 July 2018

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Structural aspects of the distinct biochemical properties of glutaredoxin 1 and glutaredoxin 2 from Saccharomyces cerevisiae

12 July 2018

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Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis

12 July 2018

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Molecular mechanisms and clinical implications of reversible protein S-glutathionylation

12 July 2018

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Clinical therapy of schistosomiasis mansoni: the Brazilian contribution

12 July 2018

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The synergistic effect of concomitant schistosomiasis, hookworm, and trichuris infections on children's anemia burden

12 July 2018

1 reference

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Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione.

12 July 2018

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Identification of oxadiazoles as new drug leads for the control of schistosomiasis

12 July 2018

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12 July 2018

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The unacknowledged impact of chronic schistosomiasis

12 July 2018

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Glutathione reductase and thioredoxin reductase at the crossroad: the structure of Schistosoma mansoni thioredoxin glutathione reductase

12 July 2018

1 reference

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Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade

12 July 2018

1 reference

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Selenoproteinless animals: selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis

12 July 2018

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Chemotherapy of schistosomiasis: present and future

12 July 2018

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Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide

12 July 2018

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Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target

12 July 2018

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12 July 2018

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Biosynthesis of selenocysteine on its tRNA in eukaryotes

12 July 2018

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12 July 2018

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Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

12 July 2018

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Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk

12 July 2018

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Characterization of alternative cytosolic forms and cellular targets of mouse mitochondrial thioredoxin reductase

12 July 2018

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Truncated mutants of human thioredoxin reductase 1 do not exhibit glutathione reductase activity

12 July 2018

1 reference

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Voltage-gated calcium channel subunits from platyhelminths: potential role in praziquantel action

12 July 2018

1 reference

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Nitric oxide: an antiparasitic molecule of invertebrates.

12 July 2018

1 reference

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Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells

12 July 2018

1 reference

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Selenocysteine in proteins-properties and biotechnological use.

12 July 2018

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Nematode selenoproteome: the use of the selenocysteine insertion system to decode one codon in an animal genome?

12 July 2018

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Recoding elements located adjacent to a subset of eukaryal selenocysteine-specifying UGA codons.

12 July 2018

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NIH Molecular Libraries Initiative

12 July 2018

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Linked thioredoxin-glutathione systems in platyhelminths

12 July 2018

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Glutaredoxins: glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system

12 July 2018

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Human mitochondrial glutaredoxin reduces S-glutathionylated proteins with high affinity accepting electrons from either glutathione or thioredoxin reductase

12 July 2018

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The thioredoxin system—From science to clinic

12 July 2018

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Active sites of thioredoxin reductases: why selenoproteins?

12 July 2018

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Characterization of mammalian selenoproteomes.

12 July 2018

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Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa

12 July 2018

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Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue

12 July 2018

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Evolutionarily different RNA motifs and RNA-protein complexes to achieve selenoprotein synthesis

12 July 2018

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The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress

12 July 2018

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The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase

12 July 2018

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Molecular bases for the anti-parasitic effect of NO (Review).

12 July 2018

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Nitric oxide in parasitic infections

12 July 2018

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Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme

12 July 2018

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Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems

12 July 2018

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Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster

12 July 2018

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Thioredoxin reductase two modes of catalysis have evolved

12 July 2018

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Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

12 July 2018

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New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements

12 July 2018

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Reactivity of the human thioltransferase (glutaredoxin) C7S, C25S, C78S, C82S mutant and NMR solution structure of its glutathionyl mixed disulfide intermediate reflect catalytic specificity

12 July 2018

1 reference

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Product of the Schistosoma mansoni glutathione peroxidase gene is a selenium containing phospholipid hydroperoxide glutathione peroxidase (PHGPx) sharing molecular weight and substrate specificity with its mammalian counterpart

12 July 2018

1 reference

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The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli

12 July 2018

1 reference

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Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel.

12 July 2018

1 reference

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A selenium-containing phospholipid-hydroperoxide glutathione peroxidase in Schistosoma mansoni

12 July 2018

1 reference

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Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene

12 July 2018

1 reference

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Kinetics and crystallographic analysis of human glutathione reductase in complex with a xanthene inhibitor

12 July 2018

1 reference

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A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity

12 July 2018

1 reference

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Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons

12 July 2018

1 reference

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Short report: diminished susceptibility to praziquantel in a Senegal isolate of Schistosoma mansoni.

12 July 2018

1 reference

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The catalytic mechanism of glutathione reductase as derived from x-ray diffraction analyses of reaction intermediates

12 July 2018

1 reference

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Survival of Schistosoma mansoni in the human host: estimates from a community-based prospective study in Puerto Rico.

12 July 2018

1 reference

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Recent advances in schistosomiasis

12 July 2018

1 reference

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Schistosoma mansoni: chemotherapy of infections of different ages

12 July 2018

1 reference

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Identification of a selenocysteyl-tRNA(Ser) in mammalian cells that recognizes the nonsense codon, UGA.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210934

Molecular cloning and sequencing of glutathione peroxidase from Schistosoma mansoni

12 July 2018

1 reference

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Structural and functional characterization of the mutant Escherichia coli glutaredoxin (C14----S) and its mixed disulfide with glutathione

12 July 2018

1 reference

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Slow Transitions and Hysteretic Behavior in Enzymes

12 July 2018

1 reference

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12 July 2018

Praziquantel resistance

1 reference

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In vitro killing action of auranofin on Taenia crassiceps metacestode (cysticerci) and inactivation of thioredoxin-glutathione reductase (TGR).

26 September 2018

1 reference

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The C-terminal active site cysteine of Escherichia coli glutaredoxin 1 determines the glutathione specificity of the second step of peptide deglutathionylation.

26 September 2018

1 reference

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Comparative modeling of thioredoxin glutathione reductase from Schistosoma mansoni: a multifunctional target for antischistosomal therapy

26 September 2018

1 reference

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Will new antischistosomal drugs finally emerge?

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210934

Reaction mechanism and regulation of mammalian thioredoxin/glutathione reductase

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210934

Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210934

Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210934

Mitochondrial thioredoxin reductase inhibition by gold(I) compounds and concurrent stimulation of permeability transition and release of cytochrome c.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210934

Purification, characterization and kinetic properties of the multifunctional thioredoxin-glutathione reductase from Taenia crassiceps metacestode (cysticerci).

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210934

Interactions of quinones with thioredoxin reductase: a challenge to the antioxidant role of the mammalian selenoprotein

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210934

The mechanism of high Mr thioredoxin reductase from Drosophila melanogaster

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210934

Alternative mRNAs arising from trans-splicing code for mitochondrial and cytosolic variants of Echinococcus granulosus thioredoxin Glutathione reductase

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210934

The biotin switch method for the detection of S-nitrosylated proteins

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210934

Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210934

Reductive and oxidative half-reactions of glutathione reductase from Escherichia coli.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210934

Efficacy and side effects of praziquantel in an epidemic focus of Schistosoma mansoni.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210934

Glutathione reductase from yeast. Differential reactivity of the nascent thiols in two-electron reduced enzyme and properties of a monoalkylated derivative.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210934

Preparation and assay of mammalian thioredoxin and thioredoxin reductase

26 September 2018

1 reference

12 December 2020

Aurothioglucose inhibits murine thioredoxin reductase activity in vivo

1 reference

12 December 2020

Kinetic aspects of regulation of metabolic processes. The hysteretic enzyme concept

1 reference

12 December 2020

Mixed disulfide with glutathione as an intermediate in the reaction catalyzed by glutathione reductase from yeast and as a major form of the enzyme in the cell

1 reference

12 December 2020

Recognition of UGA as a selenocysteine codon in Type I deiodinase requires sequences in the 3′ untranslated region

1 reference

12 December 2020

Glutathione redox state, lipid peroxide levels, and activities of glutathione enzymes in oltipraz-treated adult Schistosoma mansoni

1 reference

12 December 2020

Thioredoxin reductase from Plasmodium falciparum: evidence for interaction between the C-terminal cysteine residues and the active site disulfide-dithiol

1 reference

12 December 2020

Therapeutic evaluation of two different dose regimens of praziquantel in a recent Schistosoma mansoni focus in Northern Senegal

1 reference

12 December 2020

Furoxans as nitric oxide donors. 4-Phenyl-3-furoxancarbonitrile: thiol-mediated nitric oxide release and biological evaluation

1 reference

12 December 2020

A crystallographic study of the glutathione binding site of glutathione reductase at 0.3-nm resolution

1 reference

12 December 2020

10.1016/J.BBAGEN.2011.06.024

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21782895%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21782895%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference