Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells (Q35470405)

8 August 2017

Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells (English)

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8 August 2017

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Josh Lauring

22

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Sabrina Arena

Sabrina Arena

20

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Hiroyuki Konishi

Hiroyuki Konishi

1

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Kurt Bachman

30

Kurtis E Bachman

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Pedram Argani

29

Pedram Argani

1 reference

8 August 2017

Morassa Mohseni

2

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8 August 2017

Akina Tamaki

3

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8 August 2017

Joseph P Garay

4

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8 August 2017

Sarah Croessmann

5

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8 August 2017

Sivasundaram Karnan

6

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8 August 2017

Akinobu Ota

7

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8 August 2017

Hong Yuen Wong

8

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8 August 2017

Yuko Konishi

9

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8 August 2017

Bedri Karakas

10

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8 August 2017

Khola Tahir

11

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8 August 2017

Abde M Abukhdeir

12

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8 August 2017

John P Gustin

13

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8 August 2017

Justin Cidado

14

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8 August 2017

Grace M Wang

15

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8 August 2017

David Cosgrove

16

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8 August 2017

Rory Cochran

17

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8 August 2017

Danijela Jelovac

18

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8 August 2017

Michaela J Higgins

19

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8 August 2017

Lauren Hawkins

21

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8 August 2017

Amy L Gross

23

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8 August 2017

Christopher M Heaphy

24

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8 August 2017

Yositaka Hosokawa

25

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8 August 2017

Edward Gabrielson

26

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8 August 2017

Alan K Meeker

27

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8 August 2017

Kala Visvanathan

28

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8 August 2017

Ben Ho Park

31

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8 August 2017

language of work or name

English

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publication date

10 October 2011

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Proceedings of the National Academy of Sciences of the United States of America

8 August 2017

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8 August 2017

108

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8 August 2017

17773-17778

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8 August 2017

43

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Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations

8 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Altered proliferation and differentiation properties of primary mammary epithelial cells from BRCA1 mutation carriers.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Mouse models for BRCA1 associated tumorigenesis: from fundamental insights to preclinical utility

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Tamoxifen-stimulated growth of breast cancer due to p21 loss

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

A PCR-based high-throughput screen with multiround sample pooling: application to somatic cell gene targeting

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Prediction of BRCA1 and BRCA2 mutation status using post-irradiation assays of lymphoblastoid cell lines is compromised by inter-cell-line phenotypic variability

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Increased level of chromosomal damage after irradiation of lymphocytes from BRCA1 mutation carriers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Genetic steps of mammalian homologous repair with distinct mutagenic consequences

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

BRCA1 and BRCA2: 1994 and beyond

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Fidelity of DNA double-strand break repair in heterozygous cell lines harbouring BRCA1 missense mutations

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

BRCA1 and BRCA2 and the genetics of breast and ovarian cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

In search of the tumour-suppressor functions of BRCA1 and BRCA2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Brca1 controls homology-directed DNA repair

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Genetic instabilities in human cancers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Mutation and cancer: statistical study of retinoblastoma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Cancer chemotherapy. The relevance of certain concepts of cell cycle kinetics

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Increased progesterone receptor expression in benign epithelium of BRCA1-related breast cancers

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

MYC is amplified in BRCA1-associated breast cancers.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Germ-line mutations in BRCA1 or BRCA2 in the normal breast are associated with altered expression of estrogen-responsive proteins and the predominance of progesterone receptor A.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Breast cell invasive potential relates to the myoepithelial phenotype.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome

26 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110969108

The BRCA1 suppressor hypothesis: An explanation for the tissue-specific tumor development in BRCA1 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110969108

Correspondence re: A. Rothfuss et al., Induced micronucleus frequencies in peripheral blood lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res., 60: 390-394, 2000

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203756

Allele Imbalance, or Loss of Heterozygosity, in Normal Breast Epithelium of Sporadic Breast Cancer Cases andBRCA1Gene Mutation Carriers Is Increased Compared With Reduction Mammoplasty Tissues

24 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110969108

BRCA1 and BRCA2 heterozygosity and repair of X-ray-induced DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110969108

Gamma-rays-induced death of human cells carrying mutations of BRCA1 or BRCA2

21 January 2018

1 reference

12 December 2020

Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families

1 reference

12 December 2020

p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

1 reference

12 December 2020

Genomic alterations in histopathologically normal breast tissue from BRCA1 mutation carriers may be caused by BRCA1 haploinsufficiency

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1110969108

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8 August 2017

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1 reference

8 August 2017

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