Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures (Q35360217)

7 August 2017

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures (English)

1 reference

7 August 2017

0 references

1 reference

Ali Kassem

19

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Cecilia Engdahl

Cecilia Engdahl

11

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Marta Bally

Marta Bally

18

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Klara Sjögren

Klara Sjögren

7

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Hanna Isaksson

Hanna Isaksson

17

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Juha Tuukkanen

Juha Tuukkanen

26

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Sara Windahl

Sara H Windahl

8

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Claes Ohlsson

Claes Ohlsson

31

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Lars Sävendahl

Lars Sävendahl

23

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Anna E Börjesson

Anna E Börjesson

6

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Ulf H Lerner

Ulf H Lerner

29

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Sofia Movérare-Skrtic

1

Sofia Movérare-Skrtic

1 reference

7 August 2017

9

Helen Farman

1 reference

7 August 2017

16

Ann Hammarstedt

1 reference

7 August 2017

27

Matti Poutanen

1 reference

7 August 2017

30

Francesca Gori

1 reference

7 August 2017

20

Catharina Lindholm

1 reference

7 August 2017

Petra Henning

2

1 reference

7 August 2017

Xianwen Liu

3

1 reference

7 August 2017

Kenichi Nagano

4

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7 August 2017

Hiroaki Saito

5

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7 August 2017

Bert Kindlund

10

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7 August 2017

Antti Koskela

12

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7 August 2017

Fu-Ping Zhang

13

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7 August 2017

Emma E Eriksson

14

1 reference

7 August 2017

Farasat Zaman

15

1 reference

7 August 2017

Olof Sandberg

21

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7 August 2017

Per Aspenberg

22

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7 August 2017

Jian Q Feng

24

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7 August 2017

Jan Tuckermann

25

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7 August 2017

Roland Baron

28

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7 August 2017

language of work or name

English

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publication date

12 October 2014

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7 August 2017

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7 August 2017

20

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11

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7 August 2017

1279-1288

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https://scigraph.springernature.com/pub.10.1038/nm.3654

7 August 2017

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cites work

Wnt16 is involved in intramembranous ossification and suppresses osteoblast differentiation through the Wnt/β-catenin pathway

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Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilities

12 July 2018

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WNT signaling in bone homeostasis and disease: from human mutations to treatments

12 July 2018

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Estrogen receptor-α in osteocytes is important for trabecular bone formation in male mice

12 July 2018

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Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women

12 July 2018

1 reference

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Osteoclast progenitor cells present in significant amounts in mouse calvarial osteoblast isolations and osteoclastogenesis increased by BMP-2.

12 July 2018

1 reference

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Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche

12 July 2018

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WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk

12 July 2018

1 reference

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Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus

12 July 2018

1 reference

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Wntless functions in mature osteoblasts to regulate bone mass

12 July 2018

1 reference

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Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

12 July 2018

1 reference

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Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives

12 July 2018

1 reference

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Noncanonical Wnt signaling promotes osteoclast differentiation and is facilitated by the human immunodeficiency virus protease inhibitor ritonavir

12 July 2018

1 reference

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Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin

12 July 2018

1 reference

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Planar cell polarity signaling in the Drosophila eye.

12 July 2018

1 reference

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Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells

12 July 2018

1 reference

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Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis

12 July 2018

1 reference

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Wnt signaling from development to disease: insights from model systems

12 July 2018

1 reference

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Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Towards an integrated view of Wnt signaling in development

12 July 2018

1 reference

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Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Liposomal packaging generates Wnt protein with in vivo biological activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Osteocytes, mechanosensing and Wnt signaling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

DMP1-targeted Cre expression in odontoblasts and osteocytes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Role for WNT16B in human epidermal keratinocyte proliferation and differentiation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Wnt and calcium signaling: beta-catenin-independent pathways

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Essential role of beta-catenin in postnatal bone acquisition

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Regulation of osteoblastogenesis and bone mass by Wnt10b

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Activation of the Wnt signaling pathway in chronic lymphocytic leukemia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Differential effects on bone of estrogen receptor alpha and androgen receptor activation in orchidectomized adult male mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

High bone density due to a mutation in LDL-receptor-related protein 5

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Rapidly forming apatitic mineral in an osteoblastic cell line (UMR 106-01 BSP).

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Variation in the Kozak sequence of WNT16 results in an increased translation and is associated with osteoporosis related parameters

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Lipoproteins are an important bacterial component responsible for bone destruction through the induction of osteoclast differentiation and activation.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Hip fractures and the contribution of cortical versus trabecular bone to femoral neck strength.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Stainless steel screws coated with bisphosphonates gave stronger fixation and more surrounding bone. Histomorphometry in rats.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Calcitonin inhibits osteoclast formation in mouse haematopoetic cells independently of transcriptional regulation by receptor activator of NF-{kappa}B and c-Fms

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Tartrate-resistant acid phosphatase (Acp 5): identification in diverse human tissues and dendritic cells.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392888

Missense polymorphisms of the WNT16 gene are associated with bone mass, hip geometry and fractures

26 September 2018

1 reference

12 December 2020

Quantification of Bone Microarchitecture with the Structure Model Index

1 reference

12 December 2020

Sclerostin antibody treatment enhances metaphyseal bone healing in rats

1 reference

12 December 2020

An improved segmentation method for in vivo microCT imaging

1 reference

12 December 2020

Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.3654

1 reference

Dimensions Publication ID

7 August 2017

0 references

1 reference

7 August 2017

1 reference