Cardiotoxicity of vasodilators and positive inotropic/vasodilating drugs in dogs: an overview (Q35353001)

7 August 2017

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title

Cardiotoxicity of vasodilators and positive inotropic/vasodilating drugs in dogs: an overview (English)

1 reference

7 August 2017

Dogterom P

1

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7 August 2017

Zbinden G

series ordinal

2

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7 August 2017

Reznik GK

series ordinal

3

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7 August 2017

language of work or name

English

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publication date

1 January 1992

1 reference

Critical Reviews in Toxicology

7 August 2017

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7 August 2017

22

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7 August 2017

3-4

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7 August 2017

203-241

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The role of toxicology in drug research and development

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The current status of attempts to predict species differences in drug metabolism

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Species specificity in the metabolism of nabilone. Relationship between toxicity and metabolic routes

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Comparative aspects of contraceptive steroids--effects observed in beagle dogs

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The propionic acids. Gastrointestinal toxicity in various species

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The role of pharmacological profiling in safety assessment

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New positive inotropic agents in the treatment of congestive heart failure. Mechanisms of action and recent clinical developments. 1.

21 January 2018

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New positive inotropic agents in the treatment of congestive heart failure. Mechanisms of action and recent clinical developments. 2.

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Part I Digitalis glycosides: Mechanisms and manifestations of toxicity

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Cyclic AMP and mechanisms of vasodilation

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Pharmacology of positive inotropic phosphodiesterase III inhibitors

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Cardiovascular and biological effects of K+ channel openers, a class of drugs with vasorelaxant and cardioprotective properties

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Release of atrial natriuretic peptide from rat myocardium in vitro: effect of minoxidil-induced hypertrophy

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Positive inotropy contributes to the hemodynamic mechanism of action of flosequinan (BTS 49465) in the intact dog

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Pharmacological actions of APP 201-533, a novel cardiotonic agent

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Hypotensive and vasodilator actions of SK&F 24260, a new dihydropyridine derivative

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Renal function studies with propildazine alone and in combination with propranolol in dogs.

21 January 2018

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Clinical evaluation of a new antihypertensive vasodilating agent PR-G 138 Cl

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Tolmesoxide, a drug that lowers blood pressure by a direct relaxant effect on vascular smooth muscle

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UD-CG 115 ? a cardiotonic pyridazinone which elevates cyclic AMP and prolongs the action potential in guinea-pig papillary muscle

21 January 2018

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Systemic haemodynamic actions of pimobendan (UD-CG 115 BS) and its O-demethylmetabolite UD-CG 212 Cl in the conscious pig.

21 January 2018

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Studies aimed at elucidating the mechanism of action of CI-914, a new cardiotonic agent.

21 January 2018

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Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure

21 January 2018

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Hemodynamic, pharmacokinetic and clinical response to CI-930 in congestive heart failure due to ischemic or dilated cardiomyopathy

21 January 2018

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Cardiotonic activity of amrinone--Win 40680 [5-amino-3,4'-bipyridine-6(1H)-one]

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6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents

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The cardiovascular pharmacology of ICI 170777 ((6RS)-6-methyl-5-(pyrid-4-yl)-3H,6H-1,3,4- thiadiazin-2-one) a novel compound with positive inotropic and vasodilator effects

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Divergent effects of propranolol and furosemide pretreatment on acute cardiomyopathy induced by minoxidil in beagle dogs

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Sympathetic and parasympathetic components of reflex cardiostimulation during vasodilator treatment of hypertension

21 January 2018

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Characterization and pharmacological relevance of high affinity binding sites for [3H]LY186126, a cardiotonic phosphodiesterase inhibitor, in canine cardiac membranes

21 January 2018

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The inotropic effects of UK 14,275, a phosphodiesterase inhibitor, in man

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Chronotropic and inotropic actions of amrinone, carbazeran and isobutylmethyl xanthine: role of phosphodiesterase inhibition

21 January 2018

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E-type prostaglandins but not iloprost inhibit platelet activating factor-induced generation of leukotriene B4 by human polymorphonuclear leukocytes

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Zardaverine as a selective inhibitor of phosphodiesterase isozymes

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Positive Inotropic Agents

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Systemic and coronary haemodynamic effects of the new hypotensive drug L 6150

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The effects of cyclosidimine, a peripheral vasodilator drug, on blood pressure and heart rate in healthy subjects

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Haemodynamic changes in heart failure induced by a new vasodilator tolmesoxide.

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Hemodynamic effects of a new type III phosphodiesterase inhibitor (CI-914) for congestive heart failure.

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Physiologic assessment of the inotropic, vasodilator and afterload reducing effects of milrinone in subjects without cardiac disease.

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Acute dose range study of milrinone in congestive heart failure.

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Sympathetic and parasympathetic components of reflex tachycardia induced by hypotension in conscious dogs with and without heart failure

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Hemodynamic activity of L 6150. Systemic and coronary circulation

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Preclinical Pharmacology of Ro 31–6930, a New Potassium Channel Opener

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Haemodynamic profile of an inhibitor of phosphodiesterase III, adibendan (BM 14.478): comparison with nitroprusside and dobutamine in conscious dogs

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Activity of the sympathetic nervous system and renin-angiotensin system assessed by plasma hormone levels and their relation to hemodynamic abnormalities in congestive heart failure.

21 January 2018

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Effects of milrinone on coronary hemodynamics and myocardial energetics in patients with congestive heart failure.

21 January 2018

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Therapy with cyclosporine in experimental murine myocarditis with encephalomyocarditis virus

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Toxicologic studies with the hypotensive agent minoxidil

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Acute cardiomyopathy induced by the vasodilating antihypertensive agent minoxidil

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Cardiovascular alterations in dogs treated with hydralazine

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Cardiotoxicity of a new inotrope/vasodilator drug (SK&F 94120) in the dog.

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Comparative cardiovascular toxicity in dogs given inotropic agents by continuous intravenous infusion

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Assessment of the acute cardiotoxic potential of sodium nitroprusside infusions in beagle dogs

21 January 2018

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Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors

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Pharmacological analysis of the tachycardia produced by histamine and specific H1- and H2-receptor agonists in anesthetized dogs

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A comparative study of minoxidil-induced myocardial lesions in beagle dogs and miniature swine

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Review of cardiovascular findings in humans treated with minoxidil

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10.3109/10408449209145324

21 January 2018

Identifiers

DOI

1 reference

7 August 2017

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