Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites (Q35349049)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25883770%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25883770%20AND%20SRC:MED&resulttype=core&format=json

genome-wide association study

5 March 2020

main subject

0 references

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25883770%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

author name string

William R Swindell

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25883770%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Philip E Stuart

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25883770%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

John J Voorhees

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25883770%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

James T Elder

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25883770%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Andrew Johnston

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25883770%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Johann E Gudjonsson

7

1 reference

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5 March 2020

publication date

19 March 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25883770%20AND%20SRC:MED&resulttype=core&format=json

Clinical and translational medicine

5 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25883770%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

volume

4

1 reference

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5 March 2020

page(s)

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25883770%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

5 March 2020

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/4392043

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1186/s40169-015-0054-5

0 references

cites work

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Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era

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Integrative RNA-seq and microarray data analysis reveals GC content and gene length biases in the psoriasis transcriptome

12 July 2018

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12 July 2018

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More than skin-deep: the many dimensions of the psoriatic disease

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Immunology of psoriasis

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Early tissue responses in psoriasis to the antitumour necrosis factor-α biologic etanercept suggest reduced interleukin-17 receptor expression and signalling

12 July 2018

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Integrative biology approach identifies cytokine targeting strategies for psoriasis

12 July 2018

1 reference

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Regulatory genomic regions active in immune cell types explain a large proportion of the genetic risk of multiple sclerosis.

12 July 2018

1 reference

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Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms

12 July 2018

1 reference

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Functional interpretation of non-coding sequence variation: concepts and challenges

12 July 2018

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Emerging topical treatments for psoriasis

12 July 2018

1 reference

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Modulation of epidermal transcription circuits in psoriasis: new links between inflammation and hyperproliferation

12 July 2018

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Beyond GWASs: illuminating the dark road from association to function

12 July 2018

1 reference

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JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles

12 July 2018

1 reference

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The Ets transcription factor EHF as a regulator of cornea epithelial cell identity

12 July 2018

1 reference

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Topical treatments for chronic plaque psoriasis: an abridged Cochrane systematic review

12 July 2018

1 reference

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Sox proteins: regulators of cell fate specification and differentiation

12 July 2018

1 reference

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Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells

12 July 2018

1 reference

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Dissecting the psoriasis transcriptome: inflammatory- and cytokine-driven gene expression in lesions from 163 patients

12 July 2018

1 reference

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Y14 positively regulates TNF-α-induced NF-κB transcriptional activity via interacting RIP1 and TRADD beyond an exon junction complex protein.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

A brief review on the Human Encyclopedia of DNA Elements (ENCODE) project

12 July 2018

1 reference

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Creation of differentiation-specific genomic maps of human epidermis through laser capture microdissection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay

12 July 2018

1 reference

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Is junk DNA bunk? A critique of ENCODE

12 July 2018

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Robust shifts in S100a9 expression with aging: a novel mechanism for chronic inflammation

12 July 2018

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Evaluation of methods for modeling transcription factor sequence specificity

12 July 2018

1 reference

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DNA-binding specificities of human transcription factors

12 July 2018

1 reference

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Cross-study homogeneity of psoriasis gene expression in skin across a large expression range

12 July 2018

1 reference

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Multiplex genome engineering using CRISPR/Cas systems

12 July 2018

1 reference

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A dual AP-1 and SMAD decoy ODN suppresses tissue fibrosis and scarring in mice

12 July 2018

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NF-κB: an essential transcription factor in psoriasis

12 July 2018

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TFClass: an expandable hierarchical classification of human transcription factors

12 July 2018

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Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.

12 July 2018

1 reference

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Edifoligide and long-term outcomes after coronary artery bypass grafting: PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) 5-year results

12 July 2018

1 reference

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Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

Expanding the psoriasis disease profile: interrogation of the skin and serum of patients with moderate-to-severe psoriasis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

CIKS/Act1-mediated signaling by IL-17 cytokines in context: implications for how a CIKS gene variant may predispose to psoriasis.

12 July 2018

1 reference

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Heterogeneity of inflammatory and cytokine networks in chronic plaque psoriasis

12 July 2018

1 reference

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The Apaf-1-binding protein Aven is cleaved by Cathepsin D to unleash its anti-apoptotic potential

12 July 2018

1 reference

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PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription

12 July 2018

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Non-DNA-binding cofactors enhance DNA-binding specificity of a transcriptional regulatory complex.

12 July 2018

1 reference

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Pervasive sharing of genetic effects in autoimmune disease

12 July 2018

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Keratinocyte apoptosis in epidermal remodeling and clearance of psoriasis induced by UV radiation.

12 July 2018

1 reference

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Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

12 July 2018

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Mapping and analysis of chromatin state dynamics in nine human cell types

12 July 2018

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12 July 2018

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12 July 2018

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Psoriasis genetics: breaking the barrier

12 July 2018

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MER41 repeat sequences contain inducible STAT1 binding sites

12 July 2018

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Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs

12 July 2018

1 reference

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Knockdown of COPA, identified by loss-of-function screen, induces apoptosis and suppresses tumor growth in mesothelioma mouse model

12 July 2018

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hPDI: a database of experimental human protein-DNA interactions

12 July 2018

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Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling

12 July 2018

1 reference

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12 July 2018

Apoptosis in psoriasis.

1 reference

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Molecular dissection of psoriasis: integrating genetics and biology

12 July 2018

1 reference

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12 July 2018

1 reference

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Diversity and complexity in DNA recognition by transcription factors

12 July 2018

1 reference

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Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways

12 July 2018

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Pseudocounts for transcription factor binding sites.

12 July 2018

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Type I interferon: potential therapeutic target for psoriasis?

12 July 2018

1 reference

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Hair follicle stem cells are specified and function in early skin morphogenesis

12 July 2018

1 reference

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An RNA biding protein, Y14 interacts with and modulates STAT3 activation

12 July 2018

1 reference

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A statistical framework for consolidating "sibling" probe sets for Affymetrix GeneChip data

12 July 2018

1 reference

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Effect of RNA quality on transcript intensity levels in microarray analysis of human post-mortem brain tissues

12 July 2018

1 reference

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FOXM1, a typical proliferation-associated transcription factor

12 July 2018

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PLINK: a tool set for whole-genome association and population-based linkage analyses

12 July 2018

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DNA familial binding profiles made easy: comparison of various motif alignment and clustering strategies

12 July 2018

1 reference

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A single decoy oligodeoxynucleotides targeting multiple oncoproteins produces strong anticancer effects

12 July 2018

1 reference

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Linear models and empirical bayes methods for assessing differential expression in microarray experiments

12 July 2018

1 reference

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Transcription factor decoys: a new model for disease intervention

12 July 2018

1 reference

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TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes

12 July 2018

1 reference

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Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

Simpleaffy: a BioConductor package for Affymetrix Quality Control and data analysis

12 July 2018

1 reference

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Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes

12 July 2018

1 reference

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Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

Applied bioinformatics for the identification of regulatory elements

12 July 2018

1 reference

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Aberrant signalling and transcription factor activation as an explanation for the defective growth control and differentiation of keratinocytes in psoriasis: a hypothesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

12 July 2018

1 reference

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Summaries of Affymetrix GeneChip probe level data

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

Mitochondrial glycerol phosphate acyltransferase directs the incorporation of exogenous fatty acids into triacylglycerol

12 July 2018

1 reference

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The epithelium-specific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: the PREVENT single-centre, randomised, controlled trial

12 July 2018

1 reference

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Transcription-factor mutations and disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

IL-19 is a component of the pathogenetic IL-23/IL-17 cascade in psoriasis.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

Guselkumab (an IL-23-specific mAb) demonstrates clinical and molecular response in patients with moderate-to-severe psoriasis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

Clinical predictors of non-response to any tumor necrosis factor (TNF) blockers: a retrospective study

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

Interleukin-1β interferes with epidermal homeostasis through induction of insulin resistance: implications for psoriasis pathogenesis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

Experimental comparison and cross-validation of Affymetrix HT plate and cartridge array gene expression platforms.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

Signal transducer and activator of transcription 1 decoy oligodeoxynucleotide suppression of contact hypersensitivity

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriol.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

Analysis of high density expression microarrays with signed-rank call algorithms.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392043

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FS40169-015-0054-5

Interleukin-1 from epithelial cells fosters T cell-dependent skin inflammation

21 January 2018

1 reference

12 December 2020

ESE3/EHF Controls Epithelial Cell Differentiation and Its Loss Leads to Prostate Tumors with Mesenchymal and Stem-like Features

1 reference

12 December 2020

Apoptosis in established and healing psoriasis

1 reference

12 December 2020

IL-17 induces inflammation-associated gene products in blood monocytes, and treatment with ixekizumab reduces their expression in psoriasis patient blood

1 reference

12 December 2020

Transcriptional regulatory network for psoriasis

1 reference

12 December 2020

10.1186/S40169-015-0054-5

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25883770%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

5 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25883770%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25883770%20AND%20SRC:MED&resulttype=core&format=json