Optimizing therapeutic efficacy of chemopreventive agents: A critical review of delivery strategies in oral cancer chemoprevention clinical trials. (Q35307851)

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English	Optimizing therapeutic efficacy of chemopreventive agents: A critical review of delivery strategies in oral cancer chemoprevention clinical trials.	scientific article

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scholarly article

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14 January 2020

Optimizing therapeutic efficacy of chemopreventive agents: A critical review of delivery strategies in oral cancer chemoprevention clinical trials (English)

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14 January 2020

lip and oral cavity carcinoma

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Kashappa Goud H Desai

2

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14 January 2020

Steven P Schwendeman

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Steven P Schwendeman

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14 January 2020

author name string

Andrew S Holpuch

1

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14 January 2020

Susan R Mallery

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publication date

21 September 2011

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14 January 2020

Journal of Carcinogenesis

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14 January 2020

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14 January 2020

23

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Europe PubMed Central

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14 January 2020

Development and in vitro-in vivo evaluation of fenretinide-loaded oral mucoadhesive patches for site-specific chemoprevention of oral cancer

1 reference

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12 July 2018

Effects of human oral mucosal tissue, saliva, and oral microflora on intraoral metabolism and bioactivation of black raspberry anthocyanins

1 reference

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12 July 2018

Development of PLGA-based injectable delivery systems for hydrophobic fenretinide.

1 reference

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Clinical efficacy of antimicrobial mouthrinses

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Targeting angiogenesis with multitargeted tyrosine kinase inhibitors in the treatment of non-small cell lung cancer

1 reference

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1 reference

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12 July 2018

Formulation and in vitro-in vivo evaluation of black raspberry extract-loaded PLGA/PLA injectable millicylindrical implants for sustained delivery of chemopreventive anthocyanins

1 reference

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12 July 2018

Evading tumor evasion: current concepts and perspectives of anti-angiogenic cancer therapy

1 reference

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12 July 2018

Phase II randomized, placebo-controlled trial of green tea extract in patients with high-risk oral premalignant lesions

1 reference

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12 July 2018

In vitro and clinical studies of gene therapy with recombinant human adenovirus-p53 injection for oral leukoplakia

1 reference

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12 July 2018

Anthocyanins in black raspberries prevent esophageal tumors in rats.

1 reference

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12 July 2018

High-dose fenretinide in oral leukoplakia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

Distribution of anthocyanins delivered from a bioadhesive black raspberry gel following topical intraoral application in normal healthy volunteers

1 reference

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12 July 2018

Irinotecan and uridine diphosphate glucuronosyltransferase 1A1 pharmacogenetics: to test or not to test, that is the question

1 reference

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12 July 2018

Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesions

1 reference

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12 July 2018

Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries

1 reference

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12 July 2018

Effects of a topically applied bioadhesive berry gel on loss of heterozygosity indices in premalignant oral lesions

1 reference

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12 July 2018

Pilot randomized phase II study of celecoxib in oral premalignant lesions

1 reference

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12 July 2018

Intravesical treatments of bladder cancer: review.

1 reference

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12 July 2018

Overview of resistance to systemic therapy in patients with breast cancer

1 reference

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12 July 2018

Formulation and characterization of injectable poly(DL-lactide-co-glycolide) implants loaded with N-acetylcysteine, a MMP inhibitor

1 reference

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12 July 2018

A review of first-line treatment for small-cell lung cancer

1 reference

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12 July 2018

Formulation and in-vitro and in-vivo evaluation of a mucoadhesive gel containing freeze dried black raspberries: implications for oral cancer chemoprevention.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

Mechanisms of fenretinide-induced apoptosis

1 reference

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12 July 2018

Buccal bioadhesive drug delivery--a promising option for orally less efficient drugs

1 reference

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12 July 2018

Suppression of the tumorigenic phenotype in human oral squamous cell carcinoma cells by an ethanol extract derived from freeze-dried black raspberries.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

Black raspberry extracts inhibit benzo(a)pyrene diol-epoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

Selection of topically applied non-steroidal anti-inflammatory drugs for oral cancer chemoprevention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

Retinoids as chemoprevention for head and neck cancer: where do we go from here?

1 reference

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12 July 2018

An attenuated adenovirus, ONYX-015, as mouthwash therapy for premalignant oral dysplasia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

Retinoids in cancer therapy and chemoprevention: promise meets resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

Efficacy and tolerability of an intraoral benzocaine patch in the relief of spontaneous toothache pain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

Inhibition of benzo(a)pyrene diol-epoxide-induced transactivation of activated protein 1 and nuclear factor kappaB by black raspberry extracts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

The role of hypoxia-activated prodrugs in cancer therapy

1 reference

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12 July 2018

Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

Cyclooxygenase-2 and carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

bcl-2 expression and apoptotic bodies in 13-cis-retinoic acid (isotretinoin)-topically treated oral leukoplakia: a pilot study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

Phase I trial of alpha-tocopherol effects on 13-cis-retinoic acid toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

Oral leukoplakia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

13-cis-retinoic acid in the treatment of oral leukoplakia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

12 July 2018

Treatment of oral leukoplakia with topical bleomycin. A pilot study

1 reference

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12 July 2018

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1 reference

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12 July 2018

Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids)

1 reference

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12 July 2018

An effective case of local injection therapy of oral leukoplakia with bleomycin (author's transl)

1 reference

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12 July 2018

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1 reference

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12 July 2018

Phase I study of repeated intraepithelial delivery of adenoviral p53 in patients with dysplastic oral leukoplakia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

26 September 2018

Black raspberries inhibit N-nitrosomethylbenzylamine (NMBA)-induced angiogenesis in rat esophagus parallel to the suppression of COX-2 and iNOS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

26 September 2018

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1 reference

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26 September 2018

Randomized trial of fenretinide (4-HPR) to prevent recurrences, new localizations and carcinomas in patients operated on for oral leukoplakia: long-term results.

1 reference

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26 September 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

26 September 2018

Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

26 September 2018

Control of tumour vascular permeability

1 reference

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26 September 2018

Comparison of low-dose isotretinoin with beta carotene to prevent oral carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190566

26 September 2018

Topical bleomycin treatment of oral leukoplakia: a randomized double-blind clinical trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acitretin and treatment of the oral leucoplakias. A model to have an active molecules release

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mucin-containing lozenges in the treatment of intraoral problems associated with Sjögren's syndrome. A double-blind crossover study in 42 patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topical application of vitamin A to oral leukoplakia: A clinical case series

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of retinoids on oral leukoplakia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-carotene produces sustained remissions in patients with oral leukoplakia: results of a multicenter prospective trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topical treatment of oral leukoplakia with bleomycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topical bleomycin for the treatment of dysplastic oral leukoplakia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fenretinide activity in retinoid-resistant oral leukoplakia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topical bleomycin in the treatment of oral leukoplakia: a pilot study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Periodontal delivery of ipriflavone: new chitosan/PLGA film delivery system for a lipophilic drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemoprevention for dysplastic lesions of the upper aerodigestive tract

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chitosan and sodium alginate based bioadhesive tablets for intraoral drug delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral leukoplakia and malignant transformation. A follow-up study of 257 patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinoid receptor-dependent and -independent effects of N-(4-hydroxyphenyl)retinamide in F9 embryonal carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful topical treatment of oral lichen planus and leukoplakias with fenretinide (4-HPR)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical, radiologic, and histopathologic studies on pulmonary toxicity induced by treatment with bleomycin (NSC-125066)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22013393

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4103/1477-3163.85185

1 reference

Europe PubMed Central

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14 January 2020

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14 January 2020

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14 January 2020

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