E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment (Q35266392)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21846727%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

title

E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21846727%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1 reference

1

1 reference

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10 February 2020

author name string

Elisa A Waxman

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21846727%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Jason P Covy

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21846727%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Benoit I Giasson

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21846727%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

language of work or name

English

0 references

publication date

16 August 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21846727%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

10 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21846727%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

volume

286

1 reference

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10 February 2020

issue

40

1 reference

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10 February 2020

page(s)

35104-35118

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21846727%20AND%20SRC:MED&resulttype=core&format=json

Cell-to-cell transmission of non-prion protein aggregates.

10 February 2020

cites work

1 reference

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Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

27 July 2018

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Alpha-synuclein, lipids and Parkinson's disease

27 July 2018

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27 July 2018

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The propagation of prion-like protein inclusions in neurodegenerative diseases

27 July 2018

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Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

27 July 2018

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A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation

27 July 2018

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Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

27 July 2018

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Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

27 July 2018

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Research in motion: the enigma of Parkinson's disease pathology spread

27 July 2018

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Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein

27 July 2018

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Analysis of cerebellar function in Ube3a-deficient mice reveals novel genotype-specific behaviors

27 July 2018

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

27 July 2018

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Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

27 July 2018

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Non-motor symptoms in Parkinson's disease

27 July 2018

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Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.

27 July 2018

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Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation

27 July 2018

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27 July 2018

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Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered

15 November 2018

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Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.

27 July 2018

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Non-motor symptoms of Parkinson's disease: diagnosis and management

27 July 2018

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Nosology of Parkinson's disease: looking for the way out of a quagmire

27 July 2018

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The biochemistry of Parkinson's disease

27 July 2018

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The E46K mutation in alpha-synuclein increases amyloid fibril formation.

27 July 2018

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Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein

27 July 2018

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Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy.

27 July 2018

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Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications

27 July 2018

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

27 July 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

27 July 2018

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Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

27 July 2018

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alpha-Synuclein is phosphorylated in synucleinopathy lesions

27 July 2018

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Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

27 July 2018

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27 July 2018

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Induction of alpha-synuclein aggregation by intracellular nitrative insult.

27 July 2018

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Alpha-synuclein and neurodegenerative diseases

27 July 2018

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Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation

27 July 2018

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A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

27 July 2018

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Immunohistochemical and biochemical studies demonstrate a distinct profile of alpha-synuclein permutations in multiple system atrophy

27 July 2018

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Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology

27 July 2018

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Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

27 July 2018

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Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

27 July 2018

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Widespread alterations of alpha-synuclein in multiple system atrophy

27 July 2018

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27 July 2018

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Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes

27 July 2018

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Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

27 July 2018

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

27 July 2018

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27 July 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

27 July 2018

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A simple silver-gold intensification procedure for double DAB labeling studies in electron microscopy.

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method

27 July 2018

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Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.

27 July 2018

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

26 September 2018

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26 September 2018

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α-Synuclein: membrane interactions and toxicity in Parkinson's disease

26 September 2018

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26 September 2018

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Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions

26 September 2018

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26 September 2018

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26 September 2018

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26 September 2018

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Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

26 September 2018

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More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases.

26 September 2018

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Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy

26 September 2018

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Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

26 September 2018

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Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases.

26 September 2018

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Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

26 September 2018

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26 September 2018

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Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice

26 September 2018

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Prominent perikaryal expression of alpha- and beta-synuclein in neurons of dorsal root ganglion and in medullary neurons

26 September 2018

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Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

26 September 2018

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26 September 2018

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The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease.

26 September 2018

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Genetic analysis of families with Parkinson disease that carry the Ala53Thr mutation in the gene encoding alpha-synuclein

26 September 2018

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Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

26 September 2018

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The neuropathology of parkinsonism: an overview

26 September 2018

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Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.

26 September 2018

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Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

26 September 2018

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A vector for expressing foreign genes in the brains and hearts of transgenic mice

26 September 2018

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1 reference

12 December 2020

Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M111.247965

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21846727%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21846727%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1 reference