Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening. (Q35230791)

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14 March 2020

title

Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening (English)

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14 March 2020

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Cho Yeow Koh

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Wim G J Hol

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author name string

Laura Pedró-Rosa

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Ranae M Ranade

3

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Christina Eberhart

4

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Franck Madoux

5

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J Robert Gillespie

6

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Steven Brown

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Jacqueline Lohse

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Christophe L M Verlinde

10

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Erkang Fan

11

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Thomas Bannister

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Louis Scampavia

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Timothy Spicer

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Peter Hodder

16

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publication date

27 August 2014

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Journal of Biomolecular Screening

14 March 2020

published in

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volume

20

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page(s)

122-130

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issue

1

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Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness

14 March 2020

cites work

1 reference

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A multiple aminoacyl-tRNA synthetase complex that enhances tRNA-aminoacylation in African trypanosomes

13 July 2018

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Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection

13 July 2018

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Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization.

13 July 2018

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Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice

13 July 2018

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An ultra-high throughput cell-based screen for wee1 degradation inhibitors

13 July 2018

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From one amino acid to another: tRNA-dependent amino acid biosynthesis

13 July 2018

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Control of neglected tropical diseases

13 July 2018

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Drugs for bad bugs: confronting the challenges of antibacterial discovery

13 July 2018

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Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents

13 July 2018

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Characterization of the human mitochondrial methionyl-tRNA synthetase

13 July 2018

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Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase

13 July 2018

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Genomics-based identification of targets in pathogenic bacteria for potential therapeutic and diagnostic use.

13 July 2018

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

13 July 2018

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Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers

13 July 2018

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Adenosine triphosphate consumption by bacterial arginyl-transfer ribonucleic acid synthetases

13 July 2018

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Human African trypanosomiasis

13 July 2018

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21 January 2018

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Potent and selective inhibitors of bacterial methionyl tRNA synthetase derived from an oxazolone-dipeptide scaffold

15 November 2018

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Potent and selective inhibitors of Staphylococcus epidermidis tryptophanyl-tRNA synthetase.

21 January 2018

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Determining appropriate substrate conversion for enzymatic assays in high-throughput screening.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1177/1087057114548832

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14 March 2020

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