Cloning, functional analysis and post-transcriptional regulation of a type II DNA topoisomerase from Leishmania infantum. A new potential target for anti-parasite drugs. (Q35222665)

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English	Cloning, functional analysis and post-transcriptional regulation of a type II DNA topoisomerase from Leishmania infantum. A new potential target for anti-parasite drugs.	scientific article

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30 August 2019

Cloning, functional analysis and post-transcriptional regulation of a type II DNA topoisomerase from Leishmania infantum. A new potential target for anti-parasite drugs (English)

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30 August 2019

Leishmania infantum

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Joaquim Roca Bosch

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30 August 2019

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Tobias Hanke

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30 August 2019

María J Ramiro

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30 August 2019

Sonia Trigueros

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30 August 2019

Vicente Larraga

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30 August 2019

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1 August 2003

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30 August 2019

Nucleic Acids Research

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30 August 2019

31

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30 August 2019

16

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30 August 2019

4917-4928

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30 August 2019

Cellular roles of dna topoisomerases: a molecular perspective

1 reference

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13 July 2018

Nuclear DNA polymerase beta from Leishmania infantum. Cloning, molecular analysis and developmental regulation

1 reference

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13 July 2018

RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA.

1 reference

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13 July 2018

Characterisation of the gene encoding type II DNA topoisomerase from Leishmania donovani: a key molecular target in antileishmanial therapy

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13 July 2018

The topoisomerases of protozoan parasites

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13 July 2018

Identification of cis and trans elements involved in the cell cycle regulation of multiple genes in Crithidia fasciculata

1 reference

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13 July 2018

Characterization of a Leishmania donovani gene encoding a protein that closely resembles a type IB topoisomerase

1 reference

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13 July 2018

Molecular cloning, cell localization and binding affinity to DNA replication proteins of the p36/LACK protective antigen from Leishmania infantum

1 reference

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13 July 2018

More surprises from Kinetoplastida

1 reference

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13 July 2018

Expression and cellular localization of Trypanosoma cruzi type II DNA topoisomerase.

1 reference

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13 July 2018

Topoisomerase IV, not gyrase, decatenates products of site-specific recombination in Escherichia coli

1 reference

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13 July 2018

Cloning of the gp63 surface protease of Leishmania infantum. Differential post-translational modifications correlated with different infective forms

1 reference

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13 July 2018

Drugs affecting trypanosome topoisomerases

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13 July 2018

DNA topoisomerases

1 reference

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13 July 2018

Analysis of functional domain organization in DNA topoisomerase II from humans and Saccharomyces cerevisiae

1 reference

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13 July 2018

The structure and replication of kinetoplast DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=169929

13 July 2018

Nature and distribution of chromosomal intertwinings in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=169929

13 July 2018

The mechanisms of DNA topoisomerases

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13 July 2018

Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=169929

13 July 2018

Identification of an infective stage of Leishmania promastigotes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=169929

13 July 2018

Transformation of intact yeast cells treated with alkali cations

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13 July 2018

[12] One-step gene disruption in yeast

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13 July 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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13 July 2018

Metacyclogenesis is a major determinant of Leishmania promastigote virulence and attenuation

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13 July 2018

Supercoiling of intracellular DNA can occur in eukaryotic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=169929

13 July 2018

Supercoiling of the DNA template during transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=169929

13 July 2018

Evolutionary diversity of eukaryotic small-subunit rRNA genes

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13 July 2018

DNA topoisomerases as anticancer drug targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=169929

13 July 2018

The TOP2 gene of Trypanosoma brucei: a single-copy gene that shares extensive homology with other TOP2 genes encoding eukaryotic DNA topoisomerase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=169929

13 July 2018

E. coli minichromosome replication: regulation of initiation at oriC.

1 reference

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13 July 2018

DNA topoisomerases: why so many?

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13 July 2018

Replication and Transcription of Vertebrate Mitochondrial DNA

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13 July 2018

Leishmania tarentolaeminicircles of different sequence classes encode single guide RNAs located in the variable region approximately 150 bp from the conserved region

1 reference

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13 July 2018

Hydrogen peroxide-mediated toxicity for Leishmania donovani chagasi promastigotes. Role of hydroxyl radical and protection by heat shock

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13 July 2018

A hit-and-run system for targeted genetic manipulations in yeast

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13 July 2018

Cloning and characterization of the gene encoding Trypanosoma cruzi DNA topoisomerase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=169929

13 July 2018

Molecular cloning and expression of the gene encoding the kinetoplast-associated type II DNA topoisomerase of Crithidia fasciculata

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=169929

13 July 2018

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1 reference

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13 July 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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13 July 2018

Free minicircles of kinetoplast DNA in Crithidia fasciculata

1 reference

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13 July 2018

Sequence of the lacI gene

1 reference

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13 July 2018

Failure to relax negative supercoiling of DNA is a primary cause of mitotic hyper-recombination in topoisomerase-deficient yeast cells.

1 reference

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26 September 2018

A GyrB-GyrA fusion protein expressed in yeast cells is able to remove DNA supercoils but cannot substitute eukaryotic topoisomerase II.

1 reference

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26 September 2018

Involvement of DNA topoisomerase IIbeta in neuronal differentiation

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26 September 2018

The expression of the Leishmania infantum KMP-11 protein is developmentally regulated and stage specific.

1 reference

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26 September 2018

Intraerythrocytic expression of topoisomerase II from Plasmodium falciparum is developmentally regulated

1 reference

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26 September 2018

Periodic expression of nuclear and mitochondrial DNA replication genes during the trypanosomatid cell cycle

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26 September 2018

A multifunctional prokaryotic protein expression system: overproduction, affinity purification, and selective detection.

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26 September 2018

Localization of a type II DNA topoisomerase to two sites at the periphery of the kinetoplast DNA of Crithidia fasciculata

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26 September 2018

Investigating the biological functions of DNA topoisomerases in eukaryotic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907735

12 December 2020

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Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA polymerase beta mRNA determination by relative quantitative RT-PCR from Leishmania infantum intracellular amastigotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cell cycle in Crithidia fasciculata. Temporal relationships between synthesis of deoxyribonucleic acid in the nucleus and in the kinetoplast

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The replication of kinetoplast DNA networks in Crithidia fasciculata

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA topoisomerase II-catalyzed DNA decatenation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

One-step gene disruption in yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/NAR/GKG671

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12907735%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

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Europe PubMed Central

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30 August 2019

PubMed publication ID

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30 August 2019

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