Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts (Q35213717)

7 August 2017

Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts (English)

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7 August 2017

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9

Andrew J Halayko

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7 August 2017

Dedmer Schaafsma

1

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7 August 2017

Karol D McNeill

2

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7 August 2017

Mark M Mutawe

3

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7 August 2017

Saeid Ghavami

4

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7 August 2017

Helmut Unruh

5

1 reference

7 August 2017

Eric Jacques

6

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7 August 2017

Michel Laviolette

7

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7 August 2017

Jamila Chakir

8

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7 August 2017

24 August 2011

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7 August 2017

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7 August 2017

12

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7 August 2017

113

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https://scigraph.springernature.com/pub.10.1186/1465-9921-12-113

7 August 2017

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cites work

The mevalonate cascade as a target to suppress extracellular matrix synthesis by human airway smooth muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Role for protein geranylgeranylation in adult T-cell leukemia cell survival

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Inhibition of antigen-induced bronchial smooth muscle hyperresponsiveness by lovastatin in mice

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Statin use reduces decline in lung function: VA Normative Aging Study

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Remodeling in asthma and chronic obstructive pulmonary disease

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Anti-cancer therapy: targeting the mevalonate pathway

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Effects of simvastatin on cigarette smoking-induced structural and functional changes in rat lungs

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Pleiotropic effects of statins

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Relationship of airway wall thickening to an imbalance between matrix metalloproteinase-9 and its inhibitor in asthma

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Simvastatin inhibits growth factor expression and modulates profibrogenic markers in lung fibroblasts.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Isoprenoids as mediators of the biological effects of statins

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Correlation between airway responsiveness and proteoglycan production by bronchial fibroblasts from normal and asthmatic subjects

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Remodeling in asthma and chronic obstructive lung disease

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Phase I and pharmacokinetic study of the oral farnesyl transferase inhibitor SCH 66336 given twice daily to patients with advanced solid tumors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Basic fibroblast growth factor in asthma: measurement in bronchoalveolar lavage fluid basally and following allergen challenge

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

TGF-beta1 stimulation of fibronectin transcription in cultured human lung fibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine-specific phospholipase C, protein kinase C-delta, and p38, but not erk1/erk2.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

The use of statins and lung function in current and former smokers.

13 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1465-9921-12-113

Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1465-9921-12-113

Anti-inflammatory mechanism of simvastatin in mouse allergic asthma model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1465-9921-12-113

Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1465-9921-12-113

Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1465-9921-12-113

Statin use is associated with reduced mortality in COPD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1465-9921-12-113

A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1465-9921-12-113

Lovastatin inhibits bronchial hyperresponsiveness by reducing RhoA signaling in rat allergic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1465-9921-12-113

Signaling events required for transforming growth factor-beta stimulation of connective tissue growth factor expression by cultured human lung fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1465-9921-12-113

Simvastatin attenuates renal inflammation, tubular transdifferentiation and interstitial fibrosis in rats with unilateral ureteral obstruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1465-9921-12-113

Atorvastatin prevents left ventricular remodeling in spontaneously hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1465-9921-12-113

Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1465-9921-12-113

Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1465-9921-12-113

Protective effects of statin on cardiac fibrosis and apoptosis in adrenomedullin-knockout mice treated with angiotensin II and high salt loading.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Simvastatin attenuates bleomycin-induced pulmonary fibrosis in mice.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Inhibition of geranylgeranylation blocks agonist-induced actin reorganization in human airway smooth muscle cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173339

Statin Use Is Associated with Improved Function and Survival of Lung Allografts

26 September 2018

1 reference

https://api.crossref.org/works/10.1186%2F1465-9921-12-113

3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Isoprenylation Inhibitors Induce Apoptosis of Vascular Smooth Muscle Cells in Culture

21 January 2018

1 reference

12 December 2020

Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma

1 reference

12 December 2020

Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer

1 reference

12 December 2020

Primary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): a prospective randomised controlled trial

1 reference

12 December 2020

Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin

1 reference

12 December 2020

Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma

1 reference

12 December 2020

Influenza and COPD mortality protection as pleiotropic, dose-dependent effects of statins

1 reference

12 December 2020

Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986

1 reference

12 December 2020

Morphologic and functional properties of bronchial cells isolated from normal and asthmatic subjects

1 reference

12 December 2020

Identifiers

DOI

10.1186/1465-9921-12-113

1 reference

Dimensions Publication ID

7 August 2017

0 references

1 reference

7 August 2017

1 reference