Rac regulates cardiovascular superoxide through diverse molecular interactions: more than a binary GTP switch (Q35212986)

7 August 2017

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title

Rac regulates cardiovascular superoxide through diverse molecular interactions: more than a binary GTP switch (English)

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Pascal J Goldschmidt-Clermont

7 August 2017

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molecular interaction

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based on heuristic

inferred from title

author

series ordinal

3

object named as

Pascal J Goldschmidt-Clermont

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7 August 2017

David Gregg

1

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PubMed ID

12958025

7 August 2017

Frederick M Rauscher

series ordinal

2

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7 August 2017

1 October 2003

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American Journal of Physiology - Cell Physiology

7 August 2017

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7 August 2017

285

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7 August 2017

4

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7 August 2017

C723-34

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Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico

7 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

p47phox is required for atherosclerotic lesion progression in ApoE(-/-) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Pivotal role of a gp91(phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Rho GTPases and their effector proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Protein prenyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

The Dbl family of oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Integrin-mediated signals regulated by members of the rho family of GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Small guanine nucleotide-binding proteins and myocardial hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Assembly of the neutrophil respiratory burst oxidase: a direct interaction between p67PHOX and cytochrome b558.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Rac1 mediates STAT3 activation by autocrine IL-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

NAD(P)H oxidase: role in cardiovascular biology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Mechanisms of actin rearrangements mediating platelet activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Src and Rac mediate endothelin-1 and lysophosphatidic acid stimulation of the human brain natriuretic peptide promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Involvement of phosphatidylinositide 3'-kinase and Rac in platelet-derived growth factor-induced actin reorganization and chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Oxidant signaling in vascular cell growth, death, and survival : a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Localized Rac activation dynamics visualized in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Impact of HMG CoA reductase inhibition on small GTPases in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

The essential role of H2O2 in the regulation of intracellular Ca2+ by epidermal growth factor in rat-2 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Intracellular localization and preassembly of the NADPH oxidase complex in cultured endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Rac-dependent monocyte chemoattractant protein-1 production is induced by nutrient deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Inhibition of the mevalonate pathway: benefits beyond cholesterol reduction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Mechanical stress-induced DNA damage and rac-p38MAPK signal pathways mediate p53-dependent apoptosis in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Redox changes of cultured endothelial cells and actin dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Redox signaling of the arteriolar myogenic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

A mutation in the pleckstrin homology (PH) domain of the FGD1 gene in an Italian family with faciogenital dysplasia (Aarskog-Scott syndrome)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Effect of a dominant negative ras on myocardial hypertrophy by using adenoviral-mediated gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

An essential role for Rac in Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Novel competitive inhibitor of NAD(P)H oxidase assembly attenuates vascular O(2)(-) and systolic blood pressure in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Rho family proteins: coordinating cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Leukocyte polarization in cell migration and immune interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Angiotensin II-induced stimulation of p21-activated kinase and c-Jun NH2-terminal kinase is mediated by Rac1 and Nck.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

EPS8 and E3B1 transduce signals from Ras to Rac

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Signaling from Ras to Rac and beyond: not just a matter of GEFs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Angiotensin II stimulation of NAD(P)H oxidase activity: upstream mediators

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Rac regulates vascular endothelial growth factor stimulated motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Characterisation of Rac activation in thrombin- and collagen-stimulated human blood platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Rac, a small guanosine triphosphate-binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin alpha(2)beta(1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Small GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

HMG-CoA reductase inhibitor stabilizes rabbit atheroma by increasing basal NO and decreasing superoxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

p38 Mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II. Role in vascular smooth muscle cell hypertrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Rho GTPases and signaling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Withdrawal of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors elicits oxidative stress and induces endothelial dysfunction in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Role of NADPH oxidase in the vascular hypertrophic and oxidative stress response to angiotensin II in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Leukotriene B(4) stimulates Rac-ERK cascade to generate reactive oxygen species that mediates chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

NO modulates monocyte chemotactic protein-1 expression in endothelial cells under cyclic strain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Role of NADH/NADPH oxidase-derived H2O2 in angiotensin II-induced vascular hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Oxidative stress in arterial hypertension: role of NAD(P)H oxidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Guanine nucleotide exchange factors regulate specificity of downstream signaling from Rac and Cdc42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00230.2003

10.1152/AJPCELL.00230.2003

21 January 2018

Identifiers

DOI

1 reference

7 August 2017

1 reference

PubMed ID

12958025