Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progression (Q35212521)

7 August 2017

Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progression (English)

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7 August 2017

Olli Yli-Harja

9

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Greg N. Fuller

object named as

Gregory N Fuller

13

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Ilya Shmulevich

11

object named as

Ilya Shmulevich

1 reference

7 August 2017

Kristen M Turner

1

1 reference

7 August 2017

Youting Sun

2

1 reference

7 August 2017

Ping Ji

3

1 reference

7 August 2017

Kirsi J Granberg

4

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7 August 2017

Brady Bernard

5

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7 August 2017

Limei Hu

6

1 reference

7 August 2017

David E Cogdell

7

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7 August 2017

Xinhui Zhou

8

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7 August 2017

Matti Nykter

10

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7 August 2017

W K Alfred Yung

12

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7 August 2017

Wei Zhang

14

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7 August 2017

language of work or name

English

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publication date

3 March 2015

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Proceedings of the National Academy of Sciences of the United States of America

7 August 2017

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7 August 2017

112

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7 August 2017

11

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7 August 2017

3421-3426

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describes a project that uses

7 August 2017

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/4371922

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Transcriptional and posttranslational regulation of insulin-like growth factor binding protein-3 by Akt3.

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Role of AKT signaling in DNA repair and clinical response to cancer therapy

13 July 2018

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AKT3 regulates ErbB2, ErbB3 and estrogen receptor α expression and contributes to endocrine therapy resistance of ErbB2(+) breast tumor cells from Balb-neuT mice

13 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.

13 July 2018

1 reference

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High-grade gliomas: reality and hopes

13 July 2018

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The somatic genomic landscape of glioblastoma

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1.

13 July 2018

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Targeting the PI3K-AKT-mTOR signaling network in cancer

13 July 2018

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Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets

13 July 2018

1 reference

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The ATM protein: the importance of being active

13 July 2018

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Sequence analysis of mutations and translocations across breast cancer subtypes

13 July 2018

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Insulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF-κB network

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Akt2 interacts with Snail1 in the E-cadherin promoter

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Distinct biological roles for the akt family in mammary tumor progression

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

The Akt kinases: isoform specificity in metabolism and cancer

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Insulin-like growth factor binding protein 2 promotes glioma development and progression

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Perturbations of the AKT signaling pathway in human cancer

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Phase II study of perifosine in previously untreated patients with metastatic melanoma

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

WebGestalt: an integrated system for exploring gene sets in various biological contexts

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Role for Akt3/protein kinase Bgamma in attainment of normal brain size

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Antisense and dominant-negative AKT2 cDNA inhibits glioma cell invasion

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Statistical Issues in cDNA Microarray Data Analysis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Amino acid difference formula to help explain protein evolution

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Investigation of molecular alterations of AKT-3 in triple-negative breast cancer

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Akt2 and Akt3 play a pivotal role in malignant gliomas

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Induction of in vivo synthetic lethal RNAi responses to treat glioblastoma

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

The AKT inhibitor perifosine in biochemically recurrent prostate cancer: a phase II California/Pittsburgh cancer consortium trial

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

The effects of antisense AKT2 RNA on the inhibition of malignant glioma cell growth in vitro and in vivo.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4371922

26 September 2018

Identifiers

DOI

10.1073/PNAS.1414573112

1 reference

7 August 2017

0 references

1 reference

7 August 2017

1 reference