Transgenic rabbits as therapeutic protein bioreactors and human disease models (Q35209836)

7 August 2017

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title

Transgenic rabbits as therapeutic protein bioreactors and human disease models (English)

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7 August 2017

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Jianglin Fan

1

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7 August 2017

Teruo Watanabe

series ordinal

2

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7 August 2017

language of work or name

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1 September 2003

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Pharmacology & Therapeutics

7 August 2017

published in

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7 August 2017

volume

99

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7 August 2017

issue

3

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7 August 2017

page(s)

261-282

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Expression of the murine wild-type tyrosinase gene in transgenic rabbits

7 August 2017

cites work

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https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Transgenic rabbits expressing human lipoprotein lipase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Production of goats by somatic cell nuclear transfer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Overexpression of human hepatic lipase and ApoE in transgenic rabbits attenuates response to dietary cholesterol and alters lipoprotein subclass distributions

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Recombinant human acid alpha-glucosidase: high level production in mouse milk, biochemical characteristics, correction of enzyme deficiency in GSDII KO mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Human acid alpha-glucosidase from rabbit milk has therapeutic effect in mice with glycogen storage disease type II

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Increased levels of high-density lipoprotein cholesterol are ineffective in inhibiting the development of immune responses to oxidized low-density lipoprotein and atherosclerosis in transgenic rabbits expressing human apolipoprotein (apo) A-I with s

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Expression of synthetic cDNA sequences encoding human insulin-like growth factor-1 (IGF-1) in the mammary gland of transgenic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

YAC transgenesis in farm animals: rescue of albinism in rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

LCAT modulates atherogenic plasma lipoproteins and the extent of atherosclerosis only in the presence of normal LDL receptors in transgenic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Rabbit beta-casein promoter directs secretion of human interleukin-2 into the milk of transgenic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Transgenic rabbits for the production of biologically-active recombinant proteins in the milk

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Cloned rabbits produced by nuclear transfer from adult somatic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Cloned transgenic calves produced from nonquiescent fetal fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Transgenic bovine chimeric offspring produced from somatic cell-derived stem-like cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Factors affecting the efficiency of nuclear transplantation in the rabbit embryo.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Somatic cell nuclear transfer in mammals: progress and applications

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Transgenic rabbits overexpressing growth hormone develop acromegaly and diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Human nerve growth factor beta (hNGF-β): mammary gland specific expression and production in transgenic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Effect of milking frequency oh collection of milk from nursing New Zealand white rabbits1

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Human immunodeficiency virus type 1 infection of human CD4-transgenic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Inhibition of Atherosclerosis Development in Cholesterol-Fed Human Apolipoprotein A-I–Transgenic Rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Transgenic Rabbits Expressing Human Apolipoprotein A-I in the Liver

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Cholesterol-fed and transgenic rabbit models for the study of atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Overexpression of human apolipoprotein B-100 in transgenic rabbits results in increased levels of LDL and decreased levels of HDL

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Assembly of lipoprotein (a) in transgenic rabbits expressing human apolipoprotein (a)

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Transgenic rabbit models for biomedical research: current status, basic methods and future perspectives

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Transgenic rabbits expressing human apolipoprotein(a) develop more extensive atherosclerotic lesions in response to a cholesterol-rich diet

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Overexpression of lipoprotein lipase in transgenic rabbits inhibits diet-induced hypercholesterolemia and atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Expression of a single betaalpha chain protein of equine LH/CG in milk of transgenic rabbits and its biological activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Size matters: use of YACs, BACs and PACs in transgenic animals

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Genetic transformation of mouse embryos by microinjection of purified DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Derivation and characterization of putative pluripotential embryonic stem cells from preimplantation rabbit embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Production of transgenic rabbits, sheep and pigs by microinjection

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Lecithin:cholesterol acyltransferase overexpression generates hyperalpha-lipoproteinemia and a nonatherogenic lipoprotein pattern in transgenic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Scavenger receptor A gene regulatory elements target gene expression to macrophages and to foam cells of atherosclerotic lesions

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https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Transgenic animal bioreactors

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https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Lipoprotein(a) promotes smooth muscle cell proliferation and dedifferentiation in atherosclerotic lesions of human apo(a) transgenic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Lipoprotein(a) and atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Genetic manipulation of the rabbit heart via transgenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Transgenic rabbits expressing mutant essential light chain do not develop hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Correction of retinal abnormalities found in albinism by introduction of a functional tyrosinase gene in transgenic mice and rabbits.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Eight calves cloned from somatic cells of a single adult.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Superovulation of rabbits with FSH alters in vivo development of vitrified morulae

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Transgenic rabbits with lymphocytic leukemia induced by the c-myc oncogene fused with the immunoglobulin heavy chain enhancer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Increased expression of lipoprotein lipase in transgenic rabbits does not lead to abnormalities in skeletal and heart muscles

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Expression of bovine beta-lactoglobulin/human erythropoietin fusion protein in the milk of transgenic mice and rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

DNA interaction with rabbit sperm cells and its transfer into ova in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Endothelial Derived Vasorelaxation Is Impaired in Human APO A-I Transgenic Rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

HIV-1 mediates rapid apoptosis of lymphocytes from human CD4 transgenic but not normal rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Transgenic rabbits as bioreactors for the production of human growth hormone

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Transgenic animal bioreactors--where we are.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Paraoxonase Activity Is Reduced by a Pro-atherosclerotic Diet in Rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

A transgenic rabbit model for human hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Expression of active recombinant human $alpha;1-antitrypsin in transgenic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

The deleterious effects of human erythropoietin gene driven by the rabbit whey acidic protein gene promoter in transgenic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Expression and localization of matrix metalloproteinase-12 in the aorta of cholesterol-fed rabbits: relationship to lesion development

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Production of gene-targeted sheep by nuclear transfer from cultured somatic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Production of biologically active salmon calcitonin in the milk of transgenic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Mice overexpressing human lecithin: cholesterol acyltransferase are not protected against diet-induced atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Tissue Doppler imaging consistently detects myocardial contraction and relaxation abnormalities, irrespective of cardiac hypertrophy, in a transgenic rabbit model of human hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Pig cloning by microinjection of fetal fibroblast nuclei

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Methylation of cottontail rabbit papillomavirus DNA and tissue-specific expression in transgenic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Development of keratoacanthomas and squamous cell carcinomas in transgenic rabbits with targeted expression of EJras oncogene in epidermis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Reinitiated expression of EJras transgene in targeted epidermal cells of transgenic rabbits by cottontail rabbit papillomavirus infection.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Production of transgenic mice and rabbits that carry and express the human tissue plasminogen activator cDNA under the control of a bovine alpha S1 casein promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Apolipoprotein(a) yeast artificial chromosome transgenic rabbits. Lipoprotein(a) assembly with human and rabbit apolipoprotein B.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Transgenic rabbits with the integrated human 15-lipoxygenase gene driven by a lysozyme promoter: macrophage-specific expression and variable positional specificity of the transgenic enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E. Accelerated clearance of lipoproteins containing apolipoprotein B.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Developmental and tissue-specific expression of human CD4 in transgenic rabbits.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Rabbit cells expressing human CD4 and human CCR5 are highly permissive for human immunodeficiency virus type 1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Rabbit monoclonal antibodies: generating a fusion partner to produce rabbit-rabbit hybridomas

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

At last, direct evidence that lipoxygenases play a role in atherogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Nuclear reprogramming in nuclear transplant rabbit embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Recombinant human extracellular superoxide dismutase produced in milk of transgenic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Lipoprotein(a) enhances advanced atherosclerosis and vascular calcification in WHHL transgenic rabbits expressing human apolipoprotein(a).

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Association of the 5'HS4 sequence of the chicken beta-globin locus control region with human EF1 alpha gene promoter induces ubiquitous and high expression of human CD55 and CD59 cDNAs in transgenic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Transgenic rabbit models for the study of atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Transgenic rabbit models for the study of atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Recombinant human alpha-glucosidase from rabbit milk in Pompe patients.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Enzyme therapy for pompe disease with recombinant human alpha-glucosidase from rabbit milk

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

DNA preparation method can influence outcome of transgenic animal experiments

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Expression of porcine growth hormone gene in transgenic rabbits as reported by green fluorescent protein

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL-rabbit).

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Genes encoding a mouse monoclonal antibody are expressed in transgenic mice, rabbits and pigs

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Transgenic mice: a decade of progress in technology and research

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Viable offspring derived from fetal and adult mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Infection of human CD4+ rabbit cells with HIV-1: the possibility of the rabbit as a model for HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Nuclear totipotency of cultured rabbit morulae to support full-term development following nuclear transfer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Stable production of human insulin-like growth factor 1 (IGF-1) in the milk of hemi- and homozygous transgenic rabbits over several generations

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

Commercialization of proteins produced in the mammary gland

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900069-X

7 January 2021

10.1016/S0163-7258(03)00069-X

Identifiers

DOI

1 reference

7 August 2017

1 reference