Fragment-based library generation for the discovery of a peptidomimetic p53-Mdm4 inhibitor (Q35199094)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24983416%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

title

Fragment-based library generation for the discovery of a peptidomimetic p53-Mdm4 inhibitor (English)

1 reference

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21 March 2020

10

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21 March 2020

author name string

André Boltjes

1

1 reference

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21 March 2020

Yijun Huang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24983416%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Rob van de Velde

3

1 reference

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21 March 2020

Laurie Rijkee

4

1 reference

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21 March 2020

Siglinde Wolf

5

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21 March 2020

James Gaugler

6

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21 March 2020

Katarzyna Lesniak

7

1 reference

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21 March 2020

Katarzyna Guzik

8

1 reference

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21 March 2020

Tad A Holak

9

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21 March 2020

publication date

11 July 2014

1 reference

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ACS combinatorial science

21 March 2020

published in

1 reference

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21 March 2020

volume

16

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21 March 2020

issue

8

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21 March 2020

page(s)

393-396

1 reference

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The p53-MDM2/MDMX axis - A chemotype perspective

21 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

Exhaustive Fluorine Scanning toward Potent p53-Mdm2 Antagonists

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

Novel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein−protein interactions

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

1,4-Thienodiazepine-2,5-diones via MCR (I): synthesis, virtual space and p53-Mdm2 activity.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

Identification and characterization of the first small molecule inhibitor of MDMX

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

Rapid and efficient hydrophilicity tuning of p53/mdm2 antagonists

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

Isoquinolin-1-one inhibitors of the MDM2-p53 interaction

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

Molecular basis for the inhibition of p53 by Mdmx

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

MDMX: from bench to bedside

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

Efficient multicomponent reaction synthesis of the schistosomiasis drug praziquantel.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

Robust NMR screening for lead compounds using tryptophan-containing proteins.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

NMR screening for lead compounds using tryptophan-mutated proteins

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4130243

Inhibitors of the p53/hdm2 protein-protein interaction-path to the clinic

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24983416

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/CO500026B

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24983416%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24983416%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24983416%20AND%20SRC:MED&resulttype=core&format=json