Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling. (Q35196491)

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8 February 2020

title

Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling (English)

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8 February 2020

1 reference

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9

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8 February 2020

author name string

Sang Ryong Kim

1

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8 February 2020

Vincent Ries

2

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8 February 2020

Hsiao-Chun Cheng

3

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8 February 2020

Tatyana Kareva

4

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8 February 2020

Tinmarla F Oo

5

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8 February 2020

W Haung Yu

6

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8 February 2020

Karen Duff

7

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8 February 2020

Nikolai Kholodilov

8

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publication date

18 July 2011

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8 February 2020

published in

Neurobiology of Disease

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8 February 2020

volume

44

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8 February 2020

issue

2

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8 February 2020

page(s)

215-222

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Akt as a victim, villain and potential hero in Parkinson's disease pathophysiology and treatment

8 February 2020

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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

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Regulation of the postnatal development of dopamine neurons of the substantia nigra in vivo by Akt/protein kinase B.

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RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation

28 July 2018

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JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration

28 July 2018

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Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway

28 July 2018

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Absolute requirement of GDNF for adult catecholaminergic neuron survival

28 July 2018

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Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo.

28 July 2018

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Programmed cell death and new discoveries in the genetics of parkinsonism.

28 July 2018

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AKT/PKB signaling: navigating downstream

28 July 2018

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Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system

28 July 2018

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Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease

28 July 2018

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

28 July 2018

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Pten regulates neuronal arborization and social interaction in mice

28 July 2018

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Retrograde propagation of GDNF-mediated signals in sympathetic neurons

28 July 2018

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Putting a spin on the dorsal-ventral divide of the striatum.

28 July 2018

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Structure, regulation and function of PKB/AKT--a major therapeutic target

28 July 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

28 July 2018

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Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

28 July 2018

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Glial cell line-derived neurotrophic factor promotes survival and induces differentiation through the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathway respectively in PC12 cells

28 July 2018

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28 July 2018

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Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival

28 July 2018

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Neuroprotective mechanism of glial cell line-derived neurotrophic factor in mesencephalic neurons.

28 July 2018

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Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons

28 July 2018

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Inhibition of phosphatidylinositol 3-kinase activity blocks cellular differentiation mediated by glial cell line-derived neurotrophic factor in dopaminergic neurons

28 July 2018

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28 July 2018

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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26 September 2018

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Akt signal transduction dysfunction in Parkinson's disease

26 September 2018

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Role of noradrenergic signaling by the nucleus tractus solitarius in mediating opiate reward

26 September 2018

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alpha-Synuclein promoter confers susceptibility to Parkinson's disease.

26 September 2018

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Regulation of natural cell death in dopaminergic neurons of the substantia nigra by striatal glial cell line-derived neurotrophic factor in vivo.

26 September 2018

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Control of synaptic strength, a novel function of Akt.

26 September 2018

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Medial forebrain bundle axotomy during development induces apoptosis in dopamine neurons of the substantia nigra and activation of caspases in their degenerating axons

26 September 2018

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Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

26 September 2018

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Three-dimensional distribution of nigrostriatal neurons in the rat: relation to the topography of striatonigral projections

26 September 2018

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Nucleolar Disruption in Dopaminergic Neurons Leads to Oxidative Damage and Parkinsonism through Repression of Mammalian Target of Rapamycin Signaling

26 September 2018

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Demonstration of a medial to lateral gradient in the density of cholinergic neuropil in the rat striatum

15 November 2018

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12 December 2020

Secrets of the shaking palsy

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12 December 2020

Akt/protein kinase B prevents injury-induced motoneuron death and accelerates axonal regeneration

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12 December 2020

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Identifiers

DOI

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8 February 2020

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8 February 2020

PubMed publication ID

21782946

1 reference