Metal impurities cause false positives in high-throughput screening campaigns (Q35181932)

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20 March 2020

title

Metal impurities cause false positives in high-throughput screening campaigns (English)

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3

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author name string

Johannes C Hermann

1

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20 March 2020

Yingsi Chen

2

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20 March 2020

John Menke

4

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20 March 2020

Lin Gao

5

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Shelley K Gleason

6

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Nancy-Ellen Haynes

7

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Nathan Scott

8

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Ann Petersen

9

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20 March 2020

Stephen Gabriel

10

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20 March 2020

Binh Vu

11

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20 March 2020

Kelly M George

12

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20 March 2020

Arjun Narayanan

13

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20 March 2020

Shirley H Li

14

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20 March 2020

Hong Qian

15

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20 March 2020

Nanda Beatini

16

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20 March 2020

Linghao Niu

17

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20 March 2020

Qing-Fen Gan

18

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20 March 2020

publication date

12 December 2012

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ACS Medicinal Chemistry Letters

20 March 2020

published in

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volume

4

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issue

2

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page(s)

197-200

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Rethinking molecular similarity: comparing compounds on the basis of biological activity.

20 March 2020

cites work

1 reference

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13 July 2018

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Metalloregulatory proteins: metal selectivity and allosteric switching

13 July 2018

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The medicinal chemist's toolbox: an analysis of reactions used in the pursuit of drug candidates.

13 July 2018

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Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents--real hits or promiscuous artifacts?

13 July 2018

1 reference

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Protein arginine deiminase 4: a target for an epigenetic cancer therapy

13 July 2018

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Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments

13 July 2018

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Metal complexes in medicine with a focus on enzyme inhibition

13 July 2018

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Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds

13 July 2018

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Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027514

Learning from the data: mining of large high-throughput screening databases

13 July 2018

1 reference

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NMR-based quality control approach for the identification of false positives and false negatives in high throughput screening.

13 July 2018

1 reference

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Analysis of the reactions used for the preparation of drug candidate molecules

13 July 2018

1 reference

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High-throughput assays for promiscuous inhibitors.

13 July 2018

1 reference

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Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs

13 July 2018

1 reference

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Zinc-induced NF-kappaB inhibition can be modulated by changes in the intracellular metallothionein level

13 July 2018

1 reference

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Nonleadlikeness and leadlikeness in biochemical screening

13 July 2018

1 reference

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A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

13 July 2018

1 reference

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Molecular complexity and its impact on the probability of finding leads for drug discovery

13 July 2018

1 reference

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Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis

13 July 2018

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High-throughput screening: new technology for the 21st century

13 July 2018

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Design of potent selective zinc-mediated serine protease inhibitors

13 July 2018

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High-throughput screening for drug discovery

13 July 2018

1 reference

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Zn2+: an endogenous modulator of ligand- and voltage-gated ion channels

13 July 2018

1 reference

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Applicability of total reflection X-ray fluorescence (TXRF) as a screening platform for pharmaceutical inorganic impurity analysis.

13 July 2018

1 reference

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HTS promiscuity analyses for accelerating decision making

27 September 2018

1 reference

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High-throughput metal screening in pharmaceutical samples by ICP-MS with automated flow injection using a modified HPLC configuration

27 September 2018

1 reference

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A simple assay for detection of small-molecule redox activity

25 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900642

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The application of high-throughput screening to novel lead discovery

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900642

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML3003296

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900642%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

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20 March 2020

PubMed publication ID

24900642

1 reference