Thiol-based redox metabolism of protozoan parasites (Q35175499)

6 August 2017

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title

Thiol-based redox metabolism of protozoan parasites (English)

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6 August 2017

Sylke Müller

1

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6 August 2017

Eva Liebau

series ordinal

2

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6 August 2017

Rolf D Walter

series ordinal

3

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6 August 2017

R Luise Krauth-Siegel

series ordinal

4

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6 August 2017

1 July 2003

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6 August 2017

Trends in Parasitology

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6 August 2017

19

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6 August 2017

320-328

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6 August 2017

7

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Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Metabolism and functions of trypanothione in the Kinetoplastida

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Disulfide-Reductase Inhibitors as Chemotherapeutic Agents: The Design of Drugs for Trypanosomiasis and Malaria

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Enzymes of parasite thiol metabolism as drug targets

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Enzymes of the trypanothione metabolism as targets for antitrypanosomal drug development

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Design, synthesis, and biochemical evaluation of phosphonate and phosphonamidate analogs of glutathionylspermidine as inhibitors of glutathionylspermidine synthetase/amidase from Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 2: substitution of the glycine part

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Properties and biological activities of thioredoxins

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Thioredoxin reductase two modes of catalysis have evolved

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

The diversity and evolution of thioredoxin reductase: new perspectives

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Twists in catalysis: alternating conformations of Escherichia coli thioredoxin reductase

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Thioredoxin reductase from Plasmodium falciparum: evidence for interaction between the C-terminal cysteine residues and the active site disulfide-dithiol

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Thioredoxin reductase is essential for the survival of Plasmodium falciparum erythrocytic stages

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

The hydrogen hypothesis for the first eukaryote

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Antioxidant defences in the microaerophilic protozoan Trichomonas vaginalis: comparison of metronidazole-resistant and sensitive strains.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Conserved properties of hydrogenosomal and mitochondrial ADP/ATP carriers: a common origin for both organelles

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Leishmania major Friedlin chromosome 1 has an unusual distribution of protein-coding genes

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Identification and functional characterization of thioredoxin from Trypanosoma brucei brucei.

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Silencing of the thioredoxin gene in Trypanosoma brucei brucei

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Molecular cloning and characterization of a putative glutathione reductase gene, the PfGR2 gene, from Plasmodium falciparum.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Regulation of intracellular glutathione levels in erythrocytes infected with chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Glutathione reductase of the malarial parasite Plasmodium falciparum: crystal structure and inhibitor development

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Recombinant Plasmodium falciparum glutathione reductase is inhibited by the antimalarial dye methylene blue

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

The thioredoxin system of the malaria parasite Plasmodium falciparum. Glutathione reduction revisited.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Glutamate dehydrogenase, the marker protein of Plasmodium falciparum--cloning, expression and characterization of the malarial enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

1 reference

7 January 2021

Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

A second class of peroxidases linked to the trypanothione metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Tryparedoxin and tryparedoxin peroxidase

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Molecular characterization of a 2-Cys peroxiredoxin from the human malaria parasite Plasmodium falciparum

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Isolation and functional analysis of two thioredoxin peroxidases (peroxiredoxins) from Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Thioredoxin peroxidases of the malarial parasite Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

The putative glutathione peroxidase gene of Plasmodium falciparum codes for a thioredoxin peroxidase

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Genome sequence of the human malaria parasite Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from Trypanosoma

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

3-Mercaptopyruvate sulfurtransferase of Leishmania contains an unusual C-terminal extension and is involved in thioredoxin and antioxidant metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Molecular cloning and characterization of the genes encoding two isoforms of cysteine synthase in the enteric protozoan parasite Entamoeba histolytica

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Characterization of the gene encoding serine acetyltransferase, a regulated enzyme of cysteine biosynthesis from the protist parasites Entamoeba histolytica and Entamoeba dispar. Regulation and possible function of the cysteine biosynthetic pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Cloning and bacterial expression of adenosine-5'-triphosphate sulfurylase from the enteric protozoan parasite Entamoeba histolytica

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Purification and characterization of methionine gamma-lyase from Trichomonas vaginalis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5'-phosphate-dependent enzymes.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Trifluoromethionine, a prodrug designed against methionine gamma-lyase-containing pathogens, has efficacy in vitro and in vivo against Trichomonas vaginalis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Glutathione S-transferase of the malarial parasite Plasmodium falciparum: characterization of a potential drug target

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

The glutathione S-transferase from Plasmodium falciparum

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

The fate of ferriprotorphyrin IX in malaria infected erythrocytes in conjunction with the mode of action of antimalarial drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Glutathione-dependent detoxification of alpha-oxoaldehydes by the glyoxalase system: involvement in disease mechanisms and antiproliferative activity of glyoxalase I inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

D-lactate production in erythrocytes infected with Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Antimalarial activity in vitro of the glyoxalase I inhibitor diester, S-p-bromobenzylglutathione diethyl ester.

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

ABC proteins of Leishmania

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https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Efflux systems and increased trypanothione levels in arsenite-resistant Leishmania

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Overexpression of the putative thiol conjugate transporter TbMRPA causes melarsoprol resistance in Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

Plasmodium falciparum possesses a classical glutaredoxin and a second, glutaredoxin-like protein with a PICOT homology domain

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2803%2900141-7

7 January 2021

10.1016/S1471-4922(03)00141-7

Identifiers

DOI

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6 August 2017

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