Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes. (Q35172172)

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English	Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes.	scientific article

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3 February 2020

Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes (English)

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3 February 2020

ovarian carcinoma

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based on heuristic

inferred from title

2

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4

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Bronwyn M. Kivell

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Arun Kanakkanthara

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Aurora O'Brate

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Ariane Chan

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Ada Gjyrezi

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Janet Crawford

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Pisana Rawson

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Peter T Northcote

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Ernest Hamel

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Paraskevi Giannakakou

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John H Miller

13

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publication date

8 June 2011

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3 February 2020

Molecular Cancer Therapeutics

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3 February 2020

10

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3 February 2020

8

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3 February 2020

1419-1429

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3 February 2020

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3158586/fullTextXML

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The assembly-inducing laulimalide/peloruside a binding site on tubulin: molecular modeling and biochemical studies with [³H]peloruside A.

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13 July 2018

Molecular recognition of peloruside A by microtubules. The C24 primary alcohol is essential for biological activity

1 reference

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13 July 2018

Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping

1 reference

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13 July 2018

betaIII-tubulin is a multifunctional protein involved in drug sensitivity and tumorigenesis in non-small cell lung cancer

1 reference

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13 July 2018

Microtubules and resistance to tubulin-binding agents

1 reference

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13 July 2018

Human mutations that confer paclitaxel resistance.

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13 July 2018

The role of betaIII tubulin in predicting chemoresistance in non-small cell lung cancer.

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13 July 2018

A unique mode of microtubule stabilization induced by peloruside A

1 reference

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13 July 2018

Class III beta-tubulin mediates sensitivity to chemotherapeutic drugs in non small cell lung cancer

1 reference

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13 July 2018

NMR determination of the bioactive conformation of peloruside A bound to microtubules.

1 reference

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13 July 2018

Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules

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13 July 2018

Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function.

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13 July 2018

No significant role for beta tubulin mutations and mismatch repair defects in ovarian cancer resistance to paclitaxel/cisplatin

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13 July 2018

A highly epothilone B-resistant A549 cell line with mutations in tubulin that confer drug dependence

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13 July 2018

Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analogue, HTI-286, have mutations in alpha- or beta-tubulin and increased microtubule stability

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13 July 2018

Computational comparison of microtubule-stabilising agents laulimalide and peloruside with taxol and colchicine

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13 July 2018

Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158586

13 July 2018

Three steps to cancer: how phosphorylation of tubulin, tubulin tyrosine ligase and P-glycoprotein may generate and sustain cancer

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13 July 2018

Microtubules as a target for anticancer drugs

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13 July 2018

Elevated levels of microtubule destabilizing factors in a Taxol-resistant/dependent A549 cell line with an alpha-tubulin mutation.

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13 July 2018

Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells

1 reference

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13 July 2018

Multidrug resistance in cancer: role of ATP-dependent transporters

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13 July 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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13 July 2018

Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics

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13 July 2018

Structural insights into microtubule function

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13 July 2018

Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents.

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13 July 2018

Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158586

13 July 2018

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158586

13 July 2018

Paclitaxel (taxol)

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13 July 2018

The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype

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13 July 2018

Identification of conserved isotype-defining variable region sequences for four vertebrate beta tubulin polypeptide classes

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13 July 2018

Differential distribution of beta-tubulin isotypes in cerebellum

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13 July 2018

Microtubule dynamics, mitotic arrest, and apoptosis: drug-induced differential effects of betaIII-tubulin.

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27 September 2018

The hematopoietic-specific beta1-tubulin is naturally resistant to 2-methoxyestradiol and protects patients from drug-induced myelosuppression

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27 September 2018

Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly.

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27 September 2018

Mutation of the class I beta-tubulin gene does not predict response to paclitaxel for breast cancer.

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27 September 2018

The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.

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27 September 2018

Phosphorylation of beta III-tubulin.

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27 September 2018

Peloruside A: a potent cytotoxic macrolide isolated from the new zealand marine sponge Mycale sp

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12 December 2020

based on heuristic

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Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21653684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21653684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1535-7163.MCT-10-1057

1 reference

Europe PubMed Central

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3 February 2020

1 reference

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3 February 2020

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21653684%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

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