Mitogen-activated protein kinases: a new therapeutic target in cardiac pathology (Q35169365)

6 August 2017

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title

Mitogen-activated protein kinases: a new therapeutic target in cardiac pathology (English)

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6 August 2017

Tána Ravingerová

1

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6 August 2017

Miroslav Barancík

series ordinal

2

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6 August 2017

Monika Strnisková

series ordinal

3

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6 August 2017

1 May 2003

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6 August 2017

12

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Molecular and Cellular Biochemistry

inferred from page(s)

published in

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6 August 2017

247

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6 August 2017

1-2

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6 August 2017

127-138

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https://scigraph.springernature.com/pub.10.1023/a:1024119224033

6 August 2017

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cites work

p38 Triggers late preconditioning elicited by anisomycin in heart: involvement of NF-kappaB and iNOS.

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12 December 2020

Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction

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12 December 2020

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

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12 December 2020

Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells

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12 December 2020

The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes

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12 December 2020

Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy

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12 December 2020

Okadaic acid and anisomycin are protective and stimulate the SAPK/JNK pathway

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12 December 2020

Stimulation of c-Jun kinase and mitogen-activated protein kinase by ischemia and reperfusion in the perfused rat heart

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12 December 2020

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

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12 December 2020

Mitogen-activated protein kinases mediate heat shock-induced delayed protection in mouse heart.

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12 December 2020

The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase

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12 December 2020

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

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12 December 2020

Mitogen-activated protein kinase pathways

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12 December 2020

Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists, endothelin-1 and phenylephrine: a role in cardiac myocyte hypertrophy?

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12 December 2020

Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.

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12 December 2020

Activation of mitogen-activated protein kinases in the non-ischemic myocardium of an acute myocardial infarction in rats

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12 December 2020

A "second window of protection" or delayed preconditioning phenomenon: future horizons for myocardial protection?

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12 December 2020

Inhibition of the ER-kinase cascade by PD98059 and UO126 counteracts ischemic preconditioning in pig myocardium

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12 December 2020

Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart

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12 December 2020

Differential activation of extracellular signal regulated kinase isoforms in preconditioning and opioid-induced cardioprotection.

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12 December 2020

Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1.

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12 December 2020

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

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12 December 2020

Stage-specific differential activation of mitogen-activated protein kinases in hypertrophied and failing rat hearts

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12 December 2020

PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits

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12 December 2020

Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase

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12 December 2020

Inhibition of p38 MAPK alpha/beta reduces ischemic injury and does not block protective effects of preconditioning

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12 December 2020

Differential regulation of mitogen-activated protein kinases in the failing human heart in response to mechanical unloading

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12 December 2020

Possible involvement of stress-activated protein kinase signaling pathway and Fas receptor expression in prevention of ischemia/reperfusion-induced cardiomyocyte apoptosis by carvedilol

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12 December 2020

The mitogen-activated protein kinase signal transduction pathway

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12 December 2020

Inconsistent relation of MAPK activation to infarct size reduction by ischemic preconditioning in pigs

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12 December 2020

Insulin-like growth factor-II delays myocardial infarction in experimental coronary artery occlusion.

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12 December 2020

Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase

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12 December 2020

Activation of p38 MAPK induced by a multi-cycle ischaemic preconditioning protocol is associated with attenuated p38 MAPK activity during sustained ischaemia and reperfusion

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12 December 2020

Protein kinase C alpha activates RAF-1 by direct phosphorylation

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12 December 2020

Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy

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12 December 2020

Basic fibroblast growth factor is cardioprotective in ischemia-reperfusion injury

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12 December 2020

Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy

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12 December 2020

Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion

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12 December 2020

Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family

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12 December 2020

Ischemic preconditioning activates MAPKAPK2 in the isolated rabbit heart: evidence for involvement of p38 MAPK

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12 December 2020

Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo

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12 December 2020

Cellular Stresses Differentially Activate c-Jun N-terminal Protein Kinases and Extracellular Signal-regulated Protein Kinases in Cultured Ventricular Myocytes

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12 December 2020

Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases

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12 December 2020

Angiotensin converting enzyme inhibitors block mitogenic signalling pathways in rat cardiac fibroblasts

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12 December 2020

Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion

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12 December 2020

Inhibition of extracellular signal-regulated kinase enhances Ischemia/Reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart

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12 December 2020

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

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12 December 2020

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

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12 December 2020

Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch

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12 December 2020

A role for the extracellular signal-regulated kinase and p38 mitogen-activated protein kinases in interleukin-1 beta-stimulated delayed signal tranducer and activator of transcription 3 activation, atrial natriuretic factor expression, and cardiac m

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12 December 2020

Ischemic preconditioning: from adenosine receptor to KATP channel

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12 December 2020

Suppression of the clinical and cytokine response to endotoxin by RWJ-67657, a p38 mitogen-activated protein-kinase inhibitor, in healthy human volunteers.

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12 December 2020

Angiotensin blockade inhibits activation of mitogen-activated protein kinases in rat balloon-injured artery

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12 December 2020

Association of mitogen-activated protein kinase with the microtubule cytoskeleton

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12 December 2020

Antiischemic effects of SB203580 are mediated through the inhibition of p38alpha mitogen-activated protein kinase: Evidence from ectopic expression of an inhibition-resistant kinase

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12 December 2020

"Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium

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12 December 2020

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

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12 December 2020

Phosphorylation state of hsp27 and p38 MAPK during preconditioning and protein phosphatase inhibitor protection of rabbit cardiomyocytes

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12 December 2020

Inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells

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12 December 2020

Phosphorylation of tyrosine 182 of p38 mitogen-activated protein kinase correlates with the protection of preconditioning in the rabbit heart

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12 December 2020

Cardiotrophin-1 protects the human myocardium from ischemic injury. Comparison with the first and second window of protection by ischemic preconditioning

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12 December 2020

Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response

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12 December 2020

Angiotensin II-induced cardiac hypertrophy is associated with different mitogen-activated protein kinase activation in normotensive and hypertensive mice

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12 December 2020

Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts

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12 December 2020

Regulation of angiotensin II-stimulated osteopontin expression in cardiac microvascular endothelial cells: role of p42/44 mitogen-activated protein kinase and reactive oxygen species

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12 December 2020

Cardiotrophin-1 phosphorylates akt and BAD, and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes

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12 December 2020

Load-induced focal adhesion kinase activation in the myocardium: role of stretch and contractile activity

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12 December 2020

Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27.

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12 December 2020

Intramyocardial infusion of FGF-1 mimics ischemic preconditioning in pig myocardium.

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12 December 2020

p38 MAPK inhibition decreases TNF-alpha production and enhances postischemic human myocardial function

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12 December 2020

Inhibition of the cardiac p38-MAPK pathway by SB203580 delays ischemic cell death

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12 December 2020

Oscillation in the activities of MEK/ERK1/2 during cardiopulmonary bypass in pigs

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12 December 2020

Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.

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12 December 2020

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6

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12 December 2020

Parallel signal processing among mammalian MAPKs

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12 December 2020

Decreased p38 MAPK activity in end-stage failing human myocardium: p38 MAPK alpha is the predominant isoform expressed in human heart

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12 December 2020

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase

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12 December 2020

Role of phasic dynamism of p38 mitogen-activated protein kinase activation in ischemic preconditioning of the canine heart.

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12 December 2020

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2

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12 December 2020

Translocation of HSP27 to sarcomere induced by ischemic preconditioning in isolated rat hearts

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12 December 2020

The p38 MAPK inhibitor, SB203580, abrogates ischaemic preconditioning in rat heart but timing of administration is critical.

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12 December 2020

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

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12 December 2020

PKC-dependent activation of p46/p54 JNKs during ischemic preconditioning in conscious rabbits

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12 December 2020

ERK and p38 MAP kinase activation are components of opioid-induced delayed cardioprotection

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12 December 2020

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

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12 December 2020

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

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12 December 2020

Delayed cardioprotection is associated with the sub-cellular relocalisation of ventricular protein kinase C epsilon, but not p42/44MAPK

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12 December 2020

SAPKs regulation of ischemic preconditioning

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12 December 2020

The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy

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12 December 2020

Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: modulation of MAP kinases activation by ischemic preconditioning

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12 December 2020

Intracellular signalling through protein kinases in the heart

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12 December 2020

Stabilization of the B-type natriuretic peptide mRNA in cardiac myocytes by alpha-adrenergic receptor activation: potential roles for protein kinase C and mitogen-activated protein kinase

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12 December 2020

Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway

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12 December 2020

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

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12 December 2020

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

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12 December 2020

Mechanical stretch induces hypertrophic responses in cardiac myocytes of angiotensin II type 1a receptor knockout mice

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12 December 2020

Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion

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12 December 2020

Depletion of mitogen-activated protein kinase using an antisense oligodeoxynucleotide approach downregulates the phenylephrine-induced hypertrophic response in rat cardiac myocytes

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12 December 2020

Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart Failure

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12 December 2020

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

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12 December 2020

p38 MAPK activity is not increased early during sustained coronary artery occlusion in preconditioned versus control rabbit heart

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12 December 2020

Cardiotrophin-1 induces heat shock protein accumulation in cultured cardiac cells and protects them from stressful stimuli.

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12 December 2020

Integration of MAP kinase signal transduction pathways at the serum response element

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12 December 2020

The stress-activated protein kinase subfamily of c-Jun kinases

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12 December 2020

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

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12 December 2020

Role of p38 mitogen-activated protein kinase in cardiac myocyte secretion of the inflammatory cytokine TNF-alpha.

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12 December 2020

Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes

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12 December 2020

Transcription factor ATF2 regulation by the JNK signal transduction pathway

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12 December 2020

Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

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12 December 2020

MEK1/2-ERK1/2 mediates alpha1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes

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12 December 2020

Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

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12 December 2020

Activation of mitogen-activated protein kinases in human heart during cardiopulmonary bypass

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12 December 2020

Activation of c-Jun N-terminal kinases and p38-mitogen-activated protein kinases in human heart failure secondary to ischaemic heart disease

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12 December 2020

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium

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12 December 2020

Identification of anisomycin-activated kinases p45 and p55 in murine cells as MAPKAP kinase-2.

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12 December 2020

Phosphorylation of c-jun mediated by MAP kinases.

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12 December 2020

Extracellular Signal-regulated Kinase Plays an Essential Role in Hypertrophic Agonists, Endothelin-1 and Phenylephrine-induced Cardiomyocyte Hypertrophy

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12 December 2020

Angiotensin II and other hypertrophic stimuli mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6 kinase in cardiac myocytes. The critical role of Ca(2+)-dependent signaling

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12 December 2020

c-Jun N-terminal kinase-interacting protein 1 inhibits gene expression in response to hypertrophic agonists in neonatal rat ventricular myocytes

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12 December 2020

BCL-2 family members and the mitochondria in apoptosis

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12 December 2020

Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli

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12 December 2020

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

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12 December 2020

An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia

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12 December 2020

Stimulation of "stress-regulated" mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses

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12 December 2020

Pharmacological inhibitors of MAPK pathways.

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12 December 2020

Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy

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12 December 2020

Ischemic preconditioning triggers the activation of MAP kinases and MAPKAP kinase 2 in rat hearts

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12 December 2020

SB 203580, an inhibitor of p38 MAPK, abolishes infarct-limiting effect of ischemic preconditioning in isolated rabbit hearts

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12 December 2020

Protein tyrosine kinase is downstream of protein kinase C for ischemic preconditioning's anti-infarct effect in the rabbit heart

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12 December 2020

The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo

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12 December 2020

cPLA2 is phosphorylated and activated by MAP kinase

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12 December 2020

Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

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12 December 2020

Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes

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12 December 2020

Dual leucine zipper-bearing kinase (DLK) activates p46SAPK and p38mapk but not ERK2.

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12 December 2020

Stress-activated protein kinase phosphorylation during cardioprotection in the ischemic myocardium

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12 December 2020

Involvement of protein kinase C and Src family tyrosine kinase in Galphaq/11-induced activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase

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12 December 2020

Identifiers

DOI

10.1023/A:1024119224033

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Dimensions Publication ID

6 August 2017

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