Clinical biomarkers in drug discovery and development (Q35167912)

6 August 2017

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title

Clinical biomarkers in drug discovery and development (English)

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6 August 2017

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Richard Frank

1

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PubMed ID

12838269

6 August 2017

Richard Hargreaves

series ordinal

2

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6 August 2017

1 July 2003

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Nature Reviews Drug Discovery

6 August 2017

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6 August 2017

2

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6 August 2017

7

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6 August 2017

566-580

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https://scigraph.springernature.com/pub.10.1038/nrd1130

6 August 2017

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Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial

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Dynamics of gray matter loss in Alzheimer's disease.

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Use of positron emission tomography in oncology and its potential role to assess response to imatinib mesylate therapy in gastrointestinal stromal tumors (GISTs).

31 March 2020

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Detection of locoregional and distant recurrences in breast cancer patients by using FDG PET.

31 March 2020

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Metabolic flare: indicator of hormone responsiveness in advanced breast cancer

31 March 2020

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31 March 2020

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The role of PET in localization of neuroendocrine and adrenocortical tumors

31 March 2020

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Characterizing tumors using metabolic imaging: PET imaging of cellular proliferation and steroid receptors

31 March 2020

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Selective serotonin reuptake inhibitors and neuroendocrine function

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Emotion elicitation using films

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Crying threshold and intensity in major depressive disorder

31 March 2020

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Dissociable prefrontal brain systems for attention and emotion

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Exacerbation of pain by anxiety is associated with activity in a hippocampal network.

31 March 2020

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Combining fMRI with a pharmacokinetic model to determine which brain areas activated by painful stimulation are specifically modulated by remifentanil

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Imaging of the disease process

31 March 2020

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Molecular imaging in drug discovery and development

31 March 2020

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Active genes are tri-methylated at K4 of histone H3

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31 March 2020

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Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression

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Delayed ontogenesis of CYP1A2 in the human liver

31 March 2020

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Pharmacogenetics and pharmacogenomics.

31 March 2020

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Intracellular pharmacology of nucleoside analogues and protease inhibitors: role of transporter molecules

31 March 2020

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Physiologically based pharmacokinetics of cyclosporine A: reevaluation of dose-nonlinear kinetics in rats.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness

31 March 2020

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Clinical proteomics: translating benchside promise into bedside reality

31 March 2020

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Comprehensive phenotyping and biological marker discovery

31 March 2020

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Drusen proteome analysis: an approach to the etiology of age-related macular degeneration.

31 March 2020

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Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics

31 March 2020

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Use of proteomic patterns in serum to identify ovarian cancer

31 March 2020

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Shotgun proteomics and biomarker discovery.

31 March 2020

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The use of surrogate endpoints to assess potential toxicity in humans

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Biomarker discovery by comprehensive phenotyping for autoimmune diseases

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Long term anti-tumour necrosis factor alpha monotherapy in rheumatoid arthritis: effect on radiological course and prognostic value of markers of cartilage turnover and endothelial activation.

31 March 2020

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31 March 2020

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Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis

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Distribution of aggrecanase (ADAMts 4/5) cleavage products in normal and osteoarthritic human articular cartilage: the influence of age, topography and zone of tissue

31 March 2020

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Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices

31 March 2020

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Delineating the genetic basis of systemic lupus erythematosus

31 March 2020

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Genetics and pathophysiology of human obesity

31 March 2020

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A combined PET/CT scanner: the path to true image fusion

31 March 2020

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Functional imaging for assessment of therapy

31 March 2020

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Licensing and distribution of research tools: National Institutes of Health perspective

31 March 2020

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The patenting of tools for drug discovery and development.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1130

1 reference

6 August 2017

1 reference

PubMed ID

12838269