WT1 in acute leukemia, chronic myelogenous leukemia and myelodysplastic syndrome: therapeutic potential of WT1 targeted therapies (Q35166856)

6 August 2017

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title

WT1 in acute leukemia, chronic myelogenous leukemia and myelodysplastic syndrome: therapeutic potential of WT1 targeted therapies (English)

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6 August 2017

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myelodysplastic syndrome

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Rosenfeld C

1

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PubMed ID

12835718

6 August 2017

Cheever MA

series ordinal

2

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PubMed ID

12835718

6 August 2017

Gaiger A

series ordinal

3

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6 August 2017

1 July 2003

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6 August 2017

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6 August 2017

17

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6 August 2017

7

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6 August 2017

1301-1312

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2402988

6 August 2017

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Mutation analysis of the WT1 gene in myelodysplastic syndromes.

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Constitutive expression of the Wilms' tumor gene (WT1) in the leukemic cell line U937 blocks parts of the differentiation program

21 January 2018

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Downregulation of Wilms' tumor gene (WT1) is not a prerequisite for erythroid or megakaryocytic differentiation of the leukemic cell line K562.

21 January 2018

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Overexpression of murine WT1 + / + and - / - isoforms has no effect on chemoresistance but delays differentiation in the K562 leukemia cell line

21 January 2018

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Ribozyme-mediated cleavage of wt1 transcripts suppresses growth of leukemia cells

21 January 2018

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p53 may mediate the mdr-1 expression via the WT1 gene in human vincristine-resistant leukemia/lymphoma cell lines.

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Alternative splicing and genomic structure of the Wilms tumor gene WT1

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Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence

21 January 2018

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Transcriptional repression mediated by the WT1 Wilms tumor gene product

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Abnormal WT1 expression in the CD34-negative compartment in myelodysplastic bone marrow

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21 January 2018

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21 January 2018

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The Wilms tumor suppressor gene WT1 induces G1 arrest and apoptosis in myeloblastic leukemia M1 cells

21 January 2018

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Early detection of BCR-ABL transcripts by quantitative reverse transcriptase-polymerase chain reaction predicts outcome after allogeneic stem cell transplantation for chronic myeloid leukemia

21 January 2018

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7 January 2021

Acute lymphoblastic leukemia

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7 January 2021

Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation

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7 January 2021

The role of immunotherapy in acute myelogenous leukemia

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7 January 2021

Quantification of WT1 mRNA by competitive NASBA in AML patients

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7 January 2021

Fluorescent 5'-exonuclease assay for the absolute quantification of Wilms' tumour gene (WT1) mRNA: implications for monitoring human leukaemias

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7 January 2021

Prognostic significance of WT1 gene expression at diagnosis in adult de novo acute myeloid leukemia

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7 January 2021

The coexpression of the apoptosis-related genes bcl-2 and wt1 in predicting survival in adult acute myeloid leukemia

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7 January 2021

Mutation analysis of the WT1 gene in sporadic childhood leukaemia

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7 January 2021

wt1 gene expression in childhood leukemias

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7 January 2021

wt1 gene expression in childhood acute leukemias

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7 January 2021

Real-time quantitative PCR detection of WT1 gene expression in children with AML: prognostic significance, correlation with disease status and residual disease detection by flow cytometry

1 reference

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7 January 2021

Wilms' tumour gene (wt1) expression at diagnosis has no prognostic relevance in childhood acute lymphoblastic leukaemia treated by an intensive chemotherapy protocol

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Quantitative assessment of WT1 expression by real time quantitative PCR may be a useful tool for monitoring minimal residual disease in acute leukemia patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Expression of Wilms tumor gene (WT1) in children with acute leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Detection of the WT1 transcript by RT-PCR in complete remission has no prognostic relevance in de novo acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

The Wilms' tumor gene WT1 is a good marker for diagnosis of disease progression of myelodysplastic syndromes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Mutation of the WT1 gene in myelodysplastic syndrome and acute myeloid leukaemia post myelodysplastic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Mutation analysis of the WT1 gene in secondary leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

The Wilms' tumor gene is frequently expressed in acute myeloblastic leukemias and may provide a marker for residual blast cells detectable by PCR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Detection by monoclonal antibodies of the Wilms' tumor (WT1) nuclear protein in patients with acute leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Very low frequencies of human normal CD34+ haematopoietic progenitor cells express the Wilms' tumour gene WT1 at levels similar to those in leukaemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Forced expression of the Wilms tumor 1 (WT1) gene inhibits proliferation of human hematopoietic CD34(+) progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Suppression of Wilms' tumor gene (WT1) expression induces G2/M arrest in leukemic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Is there a graft-versus-leukaemia effect in the absence of graft-versus-host disease in patients undergoing bone marrow transplantation for acute leukaemia?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Human cytotoxic T-lymphocyte responses specific for peptides of the wild-type Wilms' tumor gene (WT1 ) product

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Cancer immunotherapy targeting Wilms' tumor gene WT1 product

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Humoral immune responses against Wilms tumor gene WT1 product in patients with hematopoietic malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Cytotoxic T-lymphocyte responses elicited to Wilms' tumor gene WT1 product by DNA vaccination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Analysis of the 11p13 Wilms' tumor suppressor gene (WT1) in ovarian tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

WT1 is an integral component of an antibody panel to distinguish pancreaticobiliary and some ovarian epithelial neoplasms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Value of molecular monitoring during the treatment of chronic myeloid leukemia: a Cancer and Leukemia Group B study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402988

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2402988

1 reference

6 August 2017

1 reference

PubMed ID

12835718