TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells. (Q35156453)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21037090%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells (English)

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15 January 2020

1

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15 January 2020

Piia Karisola

2

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15 January 2020

9

Gordon J Freeman

1 reference

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15 January 2020

author name string

Ya-Jen Chang

3

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15 January 2020

Sarah E Umetsu

4

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15 January 2020

Meixia Zhou

5

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15 January 2020

Omid Akbari

6

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15 January 2020

Norimoto Kobayashi

7

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15 January 2020

Nicole Baumgarth

8

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15 January 2020

Dale T Umetsu

10

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15 January 2020

Rosemarie H DeKruyff

11

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15 January 2020

language of work or name

English

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publication date

29 October 2010

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15 January 2020

published in

Journal of Immunology

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15 January 2020

volume

185

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15 January 2020

page(s)

6839-6849

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15 January 2020

issue

11

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describes a project that uses

15 January 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3153437/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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T Cell/Transmembrane, Ig, and Mucin-3 Allelic Variants Differentially Recognize Phosphatidylserine and Mediate Phagocytosis of Apoptotic Cells

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Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells

28 July 2018

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Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory

28 July 2018

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TIM-4 expressed on APCs induces T cell expansion and survival

28 July 2018

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Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity

28 July 2018

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Structures of T Cell Immunoglobulin Mucin Protein 4 Show a Metal-Ion-Dependent Ligand Binding Site where Phosphatidylserine Binds

28 July 2018

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TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.

28 July 2018

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Engulfment of apoptotic cells: signals for a good meal

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Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells

28 July 2018

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Identification of Tim4 as a phosphatidylserine receptor

28 July 2018

1 reference

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Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection

28 July 2018

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Measuring lymphocyte proliferation, survival and differentiation using CFSE time-series data

28 July 2018

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Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens

28 July 2018

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TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells

28 July 2018

1 reference

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Evidence for carbohydrate recognition and homotypic and heterotypic binding by the TIM family

28 July 2018

1 reference

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Cutting edge: inhibition of T cell activation by TIM-2.

28 July 2018

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Antigen recognition induces phosphatidylserine exposure on the cell surface of human CD8+ T cells

28 July 2018

1 reference

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Phagocytosis of apoptotic cells and immune regulation

28 July 2018

1 reference

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The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

28 July 2018

1 reference

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T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation

28 July 2018

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The role of apoptosis in the development and function of T lymphocytes

28 July 2018

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The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance

28 July 2018

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TIM-1 induces T cell activation and inhibits the development of peripheral tolerance

28 July 2018

1 reference

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Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

28 July 2018

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Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.

28 July 2018

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Macrophage recognition of externalized phosphatidylserine and phagocytosis of apoptotic Jurkat cells--existence of a threshold

28 July 2018

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Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice.

28 July 2018

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Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

28 July 2018

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Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

28 July 2018

1 reference

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Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family

28 July 2018

1 reference

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In vivo activation of antigen-specific CD4 T cells.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3153437

Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3153437

Immunologic basis of antigen-induced airway hyperresponsiveness

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3153437

Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3153437

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3153437

T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3153437

Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3153437

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3153437

T cell exosomes induce cholesterol accumulation in human monocytes via phosphatidylserine receptor

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3153437

TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3153437

A protocol for combining proliferation, tetramer staining and intracellular cytokine detection for the flow-cytometric analysis of antigen specific T-cells.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3153437

SMUCKLER/TIM4 is a distinct member of TIM family expressed by stromal cells of secondary lymphoid tissues and associated with lymphotoxin signaling

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3153437

Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3153437

Molecular and functional profiling of memory CD8 T cell differentiation.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3153437

Pulmonary responses to bronchoconstrictor agonists in the mouse

27 September 2018

1 reference

12 December 2020

A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice

1 reference

12 December 2020

An ovalbumin-IL-12 fusion protein is more effective than ovalbumin plus free recombinant IL-12 in inducing a T helper cell type 1-dominated immune response and inhibiting antigen-specific IgE production

1 reference

12 December 2020

Antigen-specific B cells preferentially induce CD4+ T cells to produce IL-4

1 reference

12 December 2020

Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cells

1 reference

12 December 2020

T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation

1 reference

12 December 2020

Epitope-dependent effect of anti-murine TIM-1 monoclonal antibodies on T cell activity and lung immune responses

1 reference

12 December 2020

Human TIM-1 associates with the TCR complex and up-regulates T cell activation signals

1 reference

12 December 2020

Bimodal regulation of T cell-mediated immune responses by TIM-4

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1001360

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21037090%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21037090%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference