Yeast synthetic biology platform generates novel chemical structures as scaffolds for drug discovery (Q35151192)

6 August 2017

Yeast synthetic biology platform generates novel chemical structures as scaffolds for drug discovery (English)

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6 August 2017

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1 reference

Jens Klein

1

1 reference

6 August 2017

Jonathan R Heal

2

1 reference

6 August 2017

William D O Hamilton

3

1 reference

6 August 2017

Thiamo Boussemghoune

4

1 reference

6 August 2017

Thomas Østergaard Tange

5

1 reference

6 August 2017

Fanny Delegrange

6

1 reference

6 August 2017

Georg Jaeschke

7

1 reference

6 August 2017

Anaëlle Hatsch

8

1 reference

6 August 2017

Jutta Heim

9

1 reference

6 August 2017

30 January 2014

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6 August 2017

ACS Synthetic Biology

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6 August 2017

3

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6 August 2017

5

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6 August 2017

314-323

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Visualization and virtual screening of the chemical universe database GDB-17.

6 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Natural-product-derived fragments for fragment-based ligand discovery

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Expanding medicinal chemistry space

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Experiences in fragment-based drug discovery

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Exploring the chemical space of known and unknown organic small molecules at www.gdb.unibe.ch

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

The influence of the 'organizational factor' on compound quality in drug discovery

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Yeast artificial chromosomes employed for random assembly of biosynthetic pathways and production of diverse compounds in Saccharomyces cerevisiae

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

ChemGPS-NP(Web): chemical space navigation online

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Scaffold diversity of natural products: inspiration for combinatorial library design

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

ChemGPS-NP: tuned for navigation in biologically relevant chemical space

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Drugs in other drugs: a new look at drugs as fragments

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

A ‘Rule of Three’ for fragment-based lead discovery?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Natural product guided compound library development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Molecular properties that influence the oral bioavailability of drug candidates

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Molecular complexity and its impact on the probability of finding leads for drug discovery

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

RNA-dependent replication, transcription, and persistence of brome mosaic virus RNA replicons in S. cerevisiae

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Enumeration of 166 billion organic small molecules in the chemical universe database GDB-17.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Molecular complexity and fragment-based drug discovery: ten years on.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Impact of high-throughput screening in biomedical research

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Identification of selective norbornane-type aspartate analogue inhibitors of the glutamate transporter 1 (GLT-1) from the chemical universe generated database (GDB).

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Escape from flatland: increasing saturation as an approach to improving clinical success.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

DrugBank: a comprehensive resource for in silico drug discovery and exploration

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

Fungal ABC proteins: pleiotropic drug resistance, stress response and cellular detoxification.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

In vivo DNA expression of functional brome mosaic virus RNA replicons in Saccharomyces cerevisiae.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046787

The influence of lead discovery strategies on the properties of drug candidates

27 September 2018

1 reference

12 December 2020

Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

1 reference

12 December 2020

Deconstructing fragment-based inhibitor discovery

1 reference

12 December 2020

Finding the sweet spot: the role of nature and nurture in medicinal chemistry

1 reference

12 December 2020

Cheminformatic Analysis of Natural Products and their Chemical Space

1 reference

COCI

https://opencitations.net/index/coci/api/v1/citations/10.2533/CHIMIA.2007.355

8 July 2023

Identifiers

DOI

10.1021/SB400177X

1 reference

6 August 2017

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6 August 2017

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