Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges (Q35148277)

6 August 2017

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title

Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges (English)

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6 August 2017

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2

Ulf Bredberg

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6 August 2017

Collen M Masimirembwa

series ordinal

1

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PubMed ID

12793837

6 August 2017

Tommy B Andersson

series ordinal

3

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6 August 2017

1 January 2003

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Clinical Pharmacokinetics

6 August 2017

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6 August 2017

42

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6 August 2017

515-528

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6 August 2017

6

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https://scigraph.springernature.com/pub.10.2165/00003088-200342060-00002

6 August 2017

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cites work

Structure-activity relationship in O-glucuronidation of indolocarbazole analogs

1 reference

12 December 2020

Design, synthesis, and characterization of 7-methoxy-4-(aminomethyl)coumarin as a novel and selective cytochrome P450 2D6 substrate suitable for high-throughput screening

1 reference

12 December 2020

Pharmacophore and three-dimensional quantitative structure activity relationship methods for modeling cytochrome p450 active sites

1 reference

12 December 2020

A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development

1 reference

12 December 2020

Utility of metabolic stability screening: comparison of in vitro and in vivo clearance

1 reference

12 December 2020

Computer systems for the prediction of xenobiotic metabolism

1 reference

12 December 2020

Three-dimensional quantitative structure activity relationship computational approaches for prediction of human in vitro intrinsic clearance.

1 reference

12 December 2020

Optimization of metabolic stability as a goal of modern drug design

1 reference

12 December 2020

A convenient in vitro screening method for predicting in vivo drug metabolic clearance using isolated hepatocytes suspended in serum.

1 reference

12 December 2020

Membrane transport in hepatic clearance of drugs. I: Extended hepatic clearance models incorporating concentration-dependent transport and elimination processes

1 reference

12 December 2020

QSAR model for drug human oral bioavailability.

1 reference

12 December 2020

A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.

1 reference

12 December 2020

Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

1 reference

12 December 2020

Pharmacophore modeling of cytochromes P450.

1 reference

12 December 2020

Cytochrome P450 substrate specificities, substrate structural templates and enzyme active site geometries

1 reference

12 December 2020

Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel

1 reference

12 December 2020

Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue

1 reference

12 December 2020

Use of statistical and neural net approaches in predicting toxicity of chemicals.

1 reference

12 December 2020

Drug metabolizing capacity of cryopreserved human, rat, and mouse liver parenchymal cells in suspension

1 reference

12 December 2020

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

1 reference

12 December 2020

Development of a generalized, quantitative physicochemical model of CYP3A4 inhibition for use in early drug discovery

1 reference

12 December 2020

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

1 reference

12 December 2020

High conservation of both phase I and II drug-metabolizing activities in cryopreserved rat liver slices.

1 reference

12 December 2020

High-throughput screening in drug metabolism and pharmacokinetic support of drug discovery

1 reference

12 December 2020

A pharmacophore for human pregnane X receptor ligands

1 reference

12 December 2020

Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

1 reference

12 December 2020

Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam.

1 reference

12 December 2020

A novel approach to predicting P450 mediated drug metabolism. CYP2D6 catalyzed N-dealkylation reactions and qualitative metabolite predictions using a combined protein and pharmacophore model for CYP2D6

1 reference

12 December 2020

Commentary: a physiological approach to hepatic drug clearance

1 reference

12 December 2020

Modeling the cytochrome P450-mediated metabolism of chlorinated volatile organic compounds

1 reference

12 December 2020

On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics: towards the prediction of human p450 substrate specificity and metabolism

1 reference

12 December 2020

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

1 reference

12 December 2020

Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate.

1 reference

12 December 2020

Importance of amine pKa and distribution coefficient in the metabolism of fluorinated propranolol analogs: metabolism by CYP1A2.

1 reference

12 December 2020

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

1 reference

12 December 2020

Clearance concepts in pharmacokinetics

1 reference

12 December 2020

Nonspecific binding of drugs to human liver microsomes

1 reference

12 December 2020

Effect of albumin on the estimation, in vitro, of phenytoin Vmax and Km values: implications for clinical correlation

1 reference

12 December 2020

Predicting the rates and regioselectivity of reactions mediated by the P450 superfamily

1 reference

12 December 2020

Increased post-thaw viability and phase I and II biotransformation activity in cryopreserved rat liver slices after improvement of a fast-freezing method

1 reference

12 December 2020

Quantitative structure-activity relationships of cytochrome P-450.

1 reference

12 December 2020

Structure-function of cytochromes P450 and flavin-containing monooxygenases: implications for drug metabolism

1 reference

12 December 2020

Competitive CYP2C9 inhibitors: enzyme inhibition studies, protein homology modeling, and three-dimensional quantitative structure-activity relationship analysis

1 reference

12 December 2020

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

1 reference

12 December 2020

Quantitative structure-metabolism relationships: steric and nonsteric effects in the enzymatic hydrolysis of noncongener carboxylic esters.

1 reference

12 December 2020

Modelling human cytochromes P450 for evaluating drug metabolism: an update

1 reference

12 December 2020

In vitro high throughput screening of compounds for favorable metabolic properties in drug discovery

1 reference

12 December 2020

Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans

1 reference

12 December 2020

Role of drug metabolism in drug discovery and development

1 reference

12 December 2020

Microsomal binding of amitriptyline: effect on estimation of enzyme kinetic parameters in vitro.

1 reference

12 December 2020

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

1 reference

12 December 2020

Designing safer chemicals: predicting the rates of metabolism of halogenated alkanes

1 reference

12 December 2020

10.2165/00003088-200342060-00002

Identifiers

DOI

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PubMed ID

12793837

Dimensions Publication ID

6 August 2017

0 references

1 reference

PubMed ID

12793837