An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease (Q35135962)

6 August 2017

An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease (English)

1 reference

6 August 2017

0 references

26

1 reference

6 August 2017

Carsten Saft

18

0 references

David Craufurd

17

object named as

David Craufurd

1 reference

6 August 2017

5

Chris Frost

1 reference

6 August 2017

21

Michael Orth

1 reference

6 August 2017

Bernhard Landwehrmeyer

3

object named as

G Bernhard Landwehrmeyer

1 reference

6 August 2017

20

Danuta Ryglewicz

1 reference

6 August 2017

Sigurd D Süssmuth

1

1 reference

6 August 2017

Salman Haider

2

1 reference

6 August 2017

Ruth Farmer

4

1 reference

6 August 2017

Giovanna Tripepi

6

1 reference

6 August 2017

Claus A Andersen

7

1 reference

6 August 2017

Marco Di Bacco

8

1 reference

6 August 2017

Claudia Lamanna

9

1 reference

6 August 2017

Enrica Diodato

10

1 reference

6 August 2017

Luisa Massai

11

1 reference

6 August 2017

Daniela Diamanti

12

1 reference

6 August 2017

Elisa Mori

13

1 reference

6 August 2017

Letizia Magnoni

14

1 reference

6 August 2017

Jens Dreyhaupt

15

1 reference

6 August 2017

Karin Schiefele

16

1 reference

6 August 2017

Monika Rudzinska

19

1 reference

6 August 2017

Sebastian Brzozy

22

1 reference

6 August 2017

Anna Baran

23

1 reference

6 August 2017

Giuseppe Pollio

24

1 reference

6 August 2017

Ralph Andre

25

1 reference

6 August 2017

Borje Darpo

27

1 reference

6 August 2017

Goran Westerberg

28

1 reference

6 August 2017

PADDINGTON Consortium

29

1 reference

6 August 2017

language of work or name

English

0 references

publication date

1 March 2015

1 reference

British Journal of Clinical Pharmacology

6 August 2017

1 reference

6 August 2017

79

1 reference

6 August 2017

3

1 reference

6 August 2017

465-476

1 reference

Safety, pharmacokinetics, pharmacogenomics and QT concentration-effect modelling of the SirT1 inhibitor selisistat in healthy volunteers

6 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Protective effects and mechanisms of sirtuins in the nervous system

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Observing Huntington's Disease: the European Huntington's Disease Network's REGISTRY

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Molecular mechanisms and potential therapeutical targets in Huntington's disease

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

"Frontal" behaviors before the diagnosis of Huntington's disease and their relationship to markers of disease progression: evidence of early lack of awareness

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Beyond the brain: widespread pathology in Huntington's disease

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Acetylation targets mutant huntingtin to autophagosomes for degradation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Brain SIRT1: anatomical distribution and regulation by energy availability

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Regulation of synaptic efficacy in hypocretin/orexin-containing neurons by melanin concentrating hormone in the lateral hypothalamus

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Optimizing the design of clinical trials where the outcome is a rate. Can estimating a baseline rate in a run-in period increase efficiency?

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Detection of Huntington's disease decades before diagnosis: the Predict-HD study

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Huntington's disease: molecular basis of neurodegeneration

13 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

13 July 2018

https://api.crossref.org/works/10.1111%2FBCP.12512

Rate of functional decline in Huntington's disease. Huntington Study Group

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

The hospital anxiety and depression scale

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Half a century of research on the Stroop effect: an integrative review

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

A Clinical Scale for the Self-assessment of Irritability

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: a multimodal imaging study

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Hypothalamic involvement in Huntington's disease: an in vivo PET study

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Microglial activation in presymptomatic Huntington's disease gene carriers

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Behavioral changes in Huntington Disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4345957

Unified Huntington's disease rating scale: Reliability and consistency

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FBCP.12512

sirt1-null mice develop an autoimmune-like condition

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25223731

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/BCP.12512

1 reference

6 August 2017

1 reference

6 August 2017

1 reference