A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors (Q35131941)

6 August 2017

A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors (English)

1 reference

Prolyl endopeptidase-like

6 August 2017

1 reference

GOA release 2020-03-11

10

Benjamin F Cravatt

1 reference

6 August 2017

Anna Mari Lone

1

1 reference

6 August 2017

Daniel A Bachovchin

2

1 reference

6 August 2017

David B Westwood

3

1 reference

6 August 2017

Anna E Speers

4

1 reference

6 August 2017

Timothy P Spicer

5

1 reference

6 August 2017

Virneliz Fernandez-Vega

6

1 reference

6 August 2017

Peter Chase

7

1 reference

6 August 2017

Peter S Hodder

8

1 reference

6 August 2017

Hugh Rosen

9

1 reference

6 August 2017

Alan Saghatelian

11

1 reference

6 August 2017

language of work or name

English

0 references

publication date

12 July 2011

1 reference

Journal of the American Chemical Society

6 August 2017

1 reference

6 August 2017

133

1 reference

6 August 2017

30

1 reference

6 August 2017

11665-11674

1 reference

describes a project that uses

6 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3145007/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Cooperation between NRF-2 and YY-1 transcription factors is essential for triggering the expression of the PREPL-C2ORF34 bidirectional gene pair

28 July 2018

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Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes

28 July 2018

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Decreased endogenous levels of Ac-SDKP promote organ fibrosis

28 July 2018

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PREPL: a putative novel oligopeptidase propelled into the limelight

28 July 2018

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Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome

28 July 2018

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Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.

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The PREPL A protein, a new member of the prolyl oligopeptidase family, lacking catalytic activity

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28 July 2018

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Profiling enzyme activities in vivo using click chemistry methods

28 July 2018

1 reference

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Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP.

28 July 2018

1 reference

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Prolyl peptidases: a serine protease subfamily with high potential for drug discovery.

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26.

28 July 2018

1 reference

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Genomic organization of a human cystine transporter gene (SLC3A1) and identification of novel mutations causing cystinuria

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145007

A role for glucagon-like peptide-1 in the central regulation of feeding

28 July 2018

1 reference

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Cloning and chromosomal localization of a human kidney cDNA involved in cystine, dibasic, and neutral amino acid transport

28 July 2018

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

28 July 2018

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28 July 2018

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Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

28 July 2018

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PREPL, a prolyl endopeptidase-like enzyme by name only?--Lessons from patients.

27 September 2018

1 reference

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Activity-based probes that target functional subclasses of phospholipases in proteomes

27 September 2018

1 reference

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Deletion of C2orf34, PREPL and SLC3A1 causes atypical hypotonia-cystinuria syndrome.

27 September 2018

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Global distribution of the most prevalent deletions causing hypotonia-cystinuria syndrome.

27 September 2018

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Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening.

27 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145007

Discovery of JANUVIA (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145007

(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

27 September 2018

1 reference

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Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145007

Intranasal administration of an Escherichia coli-expressed codon-optimized rotavirus VP6 protein induces protection in mice

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145007

Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145007

Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site-directed probes

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145007

Profiling serine hydrolase activities in complex proteomes

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145007

Glucagon-like peptide-1 7-36: a physiological incretin in man.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145007

Post-proline cleaving enzyme. Synthesis of a new fluorogenic substrate and distribution of the endopeptidase in rat tissues and body fluids of man

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21692504

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21692504

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JA2036095

1 reference

6 August 2017

1 reference

6 August 2017

1 reference