Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: peculiarities, mechanisms, and consequences (Q35131222)

6 August 2017

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title

Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: peculiarities, mechanisms, and consequences (English)

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6 August 2017

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Lowenstein PR

1

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6 August 2017

Castro MG

series ordinal

2

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6 August 2017

language of work or name

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1 June 2003

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6 August 2017

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6 August 2017

10

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6 August 2017

11

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6 August 2017

946-954

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3302048

6 August 2017

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A revised view of the central nervous system microenvironment and major histocompatibility complex class II antigen presentation.

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Adenovirus gene transfer causes inflammation in the brain

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Immune responses to adenovirus vectors in the nervous system

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Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination

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Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain.

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A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency

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Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB.

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7 January 2021

Adenovirus vector-induced inflammation: capsid-dependent induction of the C-C chemokine RANTES requires NF-kappa B.

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Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo

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Activation of p38 and ERK signaling during adenovirus vector cell entry lead to expression of the C-X-C chemokine IP-10.

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Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain

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Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types

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Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for ch

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7 January 2021

Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors

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7 January 2021

Humoral immune responses to adenovirus vectors in the brain

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7 January 2021

Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae

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7 January 2021

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Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination

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Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies

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7 January 2021

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7 January 2021

Recruitment, activation and proliferation of CD8+ memory T cells in an immunoprivileged site.

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7 January 2021

The immunogenicity of intracerebral virus infection depends on anatomical site.

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7 January 2021

T-cell- and macrophage-mediated axon damage in the absence of a CNS-specific immune response: involvement of metalloproteinases.

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7 January 2021

Role of the cervical lymphatics in the Th2-type hierarchy of CNS immune regulation

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7 January 2021

Afferent and efferent arms of the humoral immune response to CSF-administered albumins in a rat model with normal blood-brain barrier permeability

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7 January 2021

Disproportionate recruitment of CD8+ T cells into the central nervous system by professional antigen-presenting cells

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7 January 2021

Antigen presentation function of brain-derived dendriform cells depends on astrocyte help.

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7 January 2021

Phenotype and functions of brain dendritic cells emerging during chronic infection of mice with Toxoplasma gondii

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7 January 2021

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7 January 2021

Microglial cells in human brain have phenotypic characteristics related to possible function as dendritic antigen presenting cells

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7 January 2021

The potential role of dendritic cells in immune-mediated inflammatory diseases in the central nervous system.

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7 January 2021

Developmental plasticity of CNS microglia

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7 January 2021

Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis

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7 January 2021

Epitope spreading in immune-mediated diseases: implications for immunotherapy

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7 January 2021

Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain

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7 January 2021

A gamma34.5 mutant of herpes simplex 1 causes severe inflammation in the brain.

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7 January 2021

Stepwise dismantling of adenovirus 2 during entry into cells

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7 January 2021

An improved helper-dependent adenoviral vector allows persistent gene expression after intramuscular delivery and overcomes preexisting immunity to adenovirus

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7 January 2021

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7 January 2021

Adenovirus-pulsed dendritic cells stimulate human virus-specific T-cell responses in vitro.

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7 January 2021

Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: implications for gene therapy.

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7 January 2021

MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses.

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7 January 2021

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302048

7 January 2021

Adenovirus vector-infected cells can escape adenovirus antigen-specific cytotoxic T-lymphocyte killing in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302048

7 January 2021

Noncytolytic control of viral infections by the innate and adaptive immune response

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302048

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302048

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Dimensions Publication ID

6 August 2017

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