Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro. (Q35130860)

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English	Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro.	scientific article

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15 February 2020

Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro (English)

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15 February 2020

Andrzej Slominski

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15 February 2020

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Tae-Kang Kim

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15 February 2020

Zongtao Lin

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15 February 2020

William J Tidwell

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15 February 2020

We Li

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27 August 2014

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15 February 2020

Molecular and Cellular Endocrinology

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15 February 2020

404

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1-8

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15 February 2020

Cytochromes p450 and skin cancer: role of local endocrine pathways

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13 July 2018

Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells.

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Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system

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Melatonin membrane receptors in peripheral tissues: distribution and functions

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Melatonin: the smart killer: the human trophoblast as a model

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Differential effects of melatonin as a broad range UV-damage preventive dermato-endocrine regulator.

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Melatonin--a pleiotropic, orchestrating regulator molecule

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20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells

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13 July 2018

Melatonin signaling and cell protection function

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13 July 2018

Melatonin: a multitasking molecule

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13 July 2018

Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells

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13 July 2018

The melatonin-producing system is fully functional in retinal pigment epithelium (ARPE-19).

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13 July 2018

Inhibitors of melanogenesis increase toxicity of cyclophosphamide and lymphocytes against melanoma cells

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13 July 2018

Thirty four years since the discovery of gastrointestinal melatonin

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13 July 2018

Metabolism of melatonin by cytochrome P450s in rat liver mitochondria and microsomes

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13 July 2018

Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair

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13 July 2018

Medical implications of melatonin: receptor-mediated and receptor-independent actions

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13 July 2018

Melatonin in the skin: synthesis, metabolism and functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344443

13 July 2018

Melatonin maintains mitochondrial membrane potential and attenuates activation of initiator (casp-9) and effector caspases (casp-3/casp-7) and PARP in UVR-exposed HaCaT keratinocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344443

13 July 2018

Melatonin and the hair follicle

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13 July 2018

Localization and biological activities of melatonin in intact and diseased gastrointestinal tract (GIT).

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13 July 2018

One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?

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13 July 2018

Melatonin in edible plants (phytomelatonin): Identification, concentrations, bioavailability and proposed functions

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13 July 2018

Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines.

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13 July 2018

Constitutive and UV-induced metabolism of melatonin in keratinocytes and cell-free systems

1 reference

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13 July 2018

On the role of melatonin in skin physiology and pathology.

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13 July 2018

Functional MT1 and MT2 melatonin receptors in mammals

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13 July 2018

The cutaneous serotoninergic/melatoninergic system: securing a place under the sun.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344443

13 July 2018

Hair follicle pigmentation

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13 July 2018

Melanin pigmentation in mammalian skin and its hormonal regulation

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13 July 2018

Isolation of melatonin and 5-methoxyindole-3-acetic acid from bovine pineal glands

1 reference

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13 July 2018

Functional activity of serotoninergic and melatoninergic systems expressed in the skin

1 reference

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13 July 2018

Serotoninergic system in hamster skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344443

13 July 2018

Serotoninergic and melatoninergic systems are fully expressed in human skin

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13 July 2018

Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells

1 reference

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13 July 2018

Neuroendocrinology of the skin

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13 July 2018

In vitro and in vivo formation of two new metabolites of melatonin.

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13 July 2018

Melatonin deacetylation: retinal vertebrate class distribution and Xenopus laevis tissue distribution.

1 reference

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13 July 2018

Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*

1 reference

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13 July 2018

Melatonin-induced inhibition of melanogenesis in hair follicles in vitro [proceedings]

1 reference

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13 July 2018

Melatonin: deacetylation to 5-methoxytryptamine by liver but not brain aryl acylamidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344443

13 July 2018

Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2'-deoxyguanosine) in ex vivo human skin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344443

27 September 2018

Melatonin prevents ultraviolet radiation-induced alterations in plasma membrane potential and intracellular pH in human keratinocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344443

27 September 2018

Melatonin increases survival of HaCaT keratinocytes by suppressing UV-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344443

27 September 2018

1 reference

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27 September 2018

A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors

1 reference

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27 September 2018

A novel metabolic pathway of melatonin: oxidation by cytochrome C.

1 reference

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27 September 2018

Metabolism of melatonin by human cytochromes p450.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344443

27 September 2018

Hormonal Control of Pigmentation

1 reference

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27 September 2018

Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase.

1 reference

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27 September 2018

Melatonin antagonizes alpha-melanocyte-stimulating hormone enhancement of melanogenesis in mouse melanoma cells by blocking the hormone-induced accumulation of the c locus tyrosinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344443

27 September 2018

Melatonin is metabolized to N-acetyl serotonin and 6-hydroxymelatonin in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/25168391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of serotonin to N-acetylserotonin, melatonin, and 5-methoxytryptamine in hamster skin culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/25168391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Melatonin inhibits proliferation and melanogenesis in rodent melanoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25168391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive regulation of melanin pigmentation by two key substrates of the melanogenic pathway, L-tyrosine and L-dopa

1 reference

https://pubmed.ncbi.nlm.nih.gov/25168391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Murine skin as a target for melatonin bioregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25168391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Placental melatonin production and melatonin receptor expression are altered in preeclampsia: new insights into the role of this hormone in pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/25168391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Melatonin in Peripheral Nerve

1 reference

https://pubmed.ncbi.nlm.nih.gov/25168391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of melatonin on human skin color

1 reference

https://pubmed.ncbi.nlm.nih.gov/25168391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-tyrosinase inhibition of melanogenesis by melatonin in hair follicles in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/25168391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.MCE.2014.07.024

1 reference

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15 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25168391%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25168391%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

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