Molecular mechanisms and regulation of iron transport (Q35130662)

6 August 2017

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title

Molecular mechanisms and regulation of iron transport (English)

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6 August 2017

Jayong Chung

1

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PubMed ID

12755454

6 August 2017

Marianne Wessling-Resnick

series ordinal

2

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6 August 2017

1 April 2003

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Critical Reviews in Clinical Laboratory Sciences

6 August 2017

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6 August 2017

40

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6 August 2017

2

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6 August 2017

151-182

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6 August 2017

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Cloning and characterization of a mammalian proton-coupled metal-ion transporter

21 January 2018

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Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

21 January 2018

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Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload

21 January 2018

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Characterization and partial purification of a ferrireductase from human duodenal microvillus membranes

21 January 2018

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An iron-regulated ferric reductase associated with the absorption of dietary iron

21 January 2018

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Characterization of a cytochrome b(558) ferric/cupric reductase from rabbit duodenal brush border membranes

21 January 2018

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Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

21 January 2018

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A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation

21 January 2018

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A novel mammalian iron-regulated protein involved in intracellular iron metabolism

21 January 2018

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Effects of copper on the expression of metal transporters in human intestinal Caco-2 cells.

21 January 2018

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Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

21 January 2018

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Mapping the gene for sex-linked anemia: an inherited defect of intestinal iron absorption in the mouse.

21 January 2018

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Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin

21 January 2018

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Aceruloplasminemia: molecular characterization of this disorder of iron metabolism

21 January 2018

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Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux

21 January 2018

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Copper repletion enhances apical iron uptake and transepithelial iron transport by Caco-2 cells

21 January 2018

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Cellular location of proteins related to iron absorption and transport

21 January 2018

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Endocytosis of the transferrin receptor requires the cytoplasmic domain but not its phosphorylation site

21 January 2018

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Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis

21 January 2018

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The transferrin receptor: role in health and disease

21 January 2018

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Chemistry and biology of eukaryotic iron metabolism

21 January 2018

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pH and the recycling of transferrin during receptor-mediated endocytosis

21 January 2018

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Binding of apotransferrin to K562 cells: explanation of the transferrin cycle

21 January 2018

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The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes

21 January 2018

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Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders.

21 January 2018

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Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family

21 January 2018

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Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo

21 January 2018

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Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE

21 January 2018

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Transferrin receptor is necessary for development of erythrocytes and the nervous system

21 January 2018

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The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22.

21 January 2018

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New mutations inactivating transferrin receptor 2 in hemochromatosis type 3.

21 January 2018

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Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation

21 January 2018

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Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis

21 January 2018

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Bleomycin-detectable iron in the plasma of premature and full-term neonates

21 January 2018

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Bleomycin-detectable iron in knee-joint synovial fluid from arthritic patients and its relationship to the extracellular antioxidant activities of caeruloplasmin, transferrin and lactoferrin

21 January 2018

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Ferrous ions detected in cerebrospinal fluid by using bleomycin and DNA damage

21 January 2018

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Efficient clearance of non-transferrin-bound iron by rat liver. Implications for hepatic iron loading in iron overload states

21 January 2018

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Biochemistry of iron uptake

21 January 2018

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The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition

21 January 2018

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An iron delivery pathway mediated by a lipocalin

21 January 2018

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Mechanisms of cellular iron acquisition: another iron in the fire

21 January 2018

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21 January 2018

Pumping iron in the '90s

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Recent advances in the molecular pathogenesis of Friedreich ataxia

21 January 2018

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Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion

21 January 2018

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The GAA triplet-repeat expansion in Friedreich ataxia interferes with transcription and may be associated with an unusual DNA structure

21 January 2018

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Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin

21 January 2018

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Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin

21 January 2018

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Frataxin is reduced in Friedreich ataxia patients and is associated with mitochondrial membranes

21 January 2018

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Human frataxin maintains mitochondrial iron homeostasis in Saccharomyces cerevisiae.

21 January 2018

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Mitochondrial control of iron homeostasis. A genome wide analysis of gene expression in a yeast frataxin-deficient strain

21 January 2018

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The mitochondrial proteins Ssq1 and Jac1 are required for the assembly of iron sulfur clusters in mitochondria

21 January 2018

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Inhibition of Fe-S cluster biosynthesis decreases mitochondrial iron export: evidence that Yfh1p affects Fe-S cluster synthesis

21 January 2018

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The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins

21 January 2018

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Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia

21 January 2018

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Inactivation of the Friedreich ataxia mouse gene leads to early embryonic lethality without iron accumulation

21 January 2018

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Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits

21 January 2018

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The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins

21 January 2018

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Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p

21 January 2018

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Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A)

21 January 2018

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ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation

21 January 2018

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A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

21 January 2018

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The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression

21 January 2018

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Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man.

21 January 2018

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HFE gene knockout produces mouse model of hereditary hemochromatosis

21 January 2018

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Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis

21 January 2018

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Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

21 January 2018

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The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

21 January 2018

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Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

21 January 2018

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The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells

21 January 2018

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Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: implications for cellular iron homeostasis

21 January 2018

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Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites

21 January 2018

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Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis

21 January 2018

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The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin

21 January 2018

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Hepcidin, a urinary antimicrobial peptide synthesized in the liver

21 January 2018

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LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

21 January 2018

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A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

21 January 2018

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Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

21 January 2018

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Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

21 January 2018

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Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice

21 January 2018

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Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

21 January 2018

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Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease

21 January 2018

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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

21 January 2018

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Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein

21 January 2018

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C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism

21 January 2018

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Intestinal iron uptake determined by divalent metal transporter is enhanced in HFE-deficient mice with hemochromatosis.

21 January 2018

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Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse.

21 January 2018

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Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease

21 January 2018

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Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload

21 January 2018

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Intestinal expression of genes involved in iron absorption in humans

21 January 2018

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Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1

21 January 2018

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Iron regulatory proteins and the molecular control of mammalian iron metabolism

21 January 2018

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Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress

21 January 2018

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Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis

21 January 2018

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Regulation of expression of murine transferrin receptor 2.

21 January 2018

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Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function

21 January 2018

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Iron-dependent regulation of the divalent metal ion transporter

21 January 2018

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The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non-transferrin-bound iron uptake

21 January 2018

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Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation.

21 January 2018

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Molecular evidence for the role of a ferric reductase in iron transport

21 January 2018

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Purification and characterization of hypoxia-inducible factor 1

21 January 2018

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

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HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation

21 January 2018

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Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency

21 January 2018

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Serum soluble transferrin receptor concentration is an accurate estimate of the mass of tissue receptors

21 January 2018

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The measurement of serum transferrin receptor

21 January 2018

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Association of phorbol ester-induced hyperphosphorylation and reversible regulation of transferrin membrane receptors in HL60 cells

21 January 2018

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Rapid internalization of the transferrin receptor in K562 cells is triggered by ligand binding or treatment with a phorbol ester

21 January 2018

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Phorbol ester treatment increases the exocytic rate of the transferrin receptor recycling pathway independent of serine-24 phosphorylation

21 January 2018

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Rapid regulation of divalent metal transporter (DMT1) protein but not mRNA expression by non-haem iron in human intestinal Caco-2 cells

21 January 2018

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Overexpression of the hereditary hemochromatosis protein, HFE, in HeLa cells induces an iron-deficient phenotype

21 January 2018

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Hereditary Defect in Iron Absorption in Mice

21 January 2018

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21 January 2018

Identifiers

DOI

10.1080/713609332

1 reference

6 August 2017

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PubMed ID

12755454