Sirolimus: its discovery, biological properties, and mechanism of action (Q35125746)

6 August 2017

1 reference

title

Sirolimus: its discovery, biological properties, and mechanism of action (English)

1 reference

6 August 2017

1 reference

1 reference

https://api.crossref.org/works/10.1016/S0041-1345(03)00211-2

1 January 2024

author name string

S. N. Sehgal

series ordinal

1

1 reference

PubMed ID

12742462

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12742462

1 January 2024

language of work or name

English

0 references

publication date

1 May 2003

1 reference

PubMed ID

12742462

full work available at URL

6 August 2017

https://api.elsevier.com/content/article/PII:S0041134503002112?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/S0041-1345(03)00211-2

https://api.elsevier.com/content/article/PII:S0041134503002112?httpAccept=text/plain

1 January 2024

1 reference

https://api.crossref.org/works/10.1016/S0041-1345(03)00211-2

Transplantation Proceedings

1 January 2024

published in

1 reference

6 August 2017

35

1 reference

6 August 2017

3 Suppl

1 reference

6 August 2017

7S-14S

1 reference

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Incorporation of acetate, propionate, and methionine into rapamycin by Streptomyces hygroscopicus

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Revised NMR assignments for rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Rapamune® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Rapamycin: a novel immunosuppressive macrolide

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

A Putative Sirolimus (Rapamycin) Effector Protein

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Rapamycin inhibits p34cdc2 expression and arrests T lymphocyte proliferation at the G1/S transition.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

New antitumor substances of natural origin

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Activity of rapamycin (AY-22,989) against transplanted tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Rapamycin blocks cell cycle progression of activated T cells prior to events characteristic of the middle to late G1 phase of the cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Rapamycin: in vitro profile of a new immunosuppressive macrolide

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

T-cell growth factors in allograft rejection and tolerance.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Inhibition of human B lymphocyte cell cycle progression and differentiation by rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Effects of cyclosporine and rapamycin on immunoglobulin production by preactivated human B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Effects of the pharmacokinetic interaction between orally administered sirolimus and cyclosporine on the synergistic prolongation of heart allograft survival in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Median effect analysis of efficacy versus adverse effects of immunosuppressants

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

FK 506 and rapamycin in combination are not antagonistic but produce extended small bowel graft survival in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Therapeutic blood levels of sirolimus (rapamycin) in the allografted rat

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

The relationship of blood concentrations of rapamycin and cyclosporine to suppression of allograft rejection in a rabbit heterotopic heart transplant model

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Synergistic mechanisms by which sirolimus and cyclosporin inhibit rat heart and kidney allograft rejection

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Effects of orally administered rapamycin in animal models of arthritis and other autoimmune diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Treatment with rapamycin and mycophenolic acid reduces arterial intimal thickening produced by mechanical injury and allows endothelial replacement.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Inhibition of intimal thickening after balloon angioplasty in porcine coronary arteries by targeting regulators of the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Sustained suppression of neointimal proliferation by sirolimus-eluting stents: one-year angiographic and intravascular ultrasound follow-up

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Sirolimus (rapamycin) halts and reverses progression of allograft vascular disease in non-human primates

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

The effect of rapamycin on renal function in the rat: a comparative study with cyclosporine

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Functional and histopathologic effects of rapamycin on mouse kidney

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Cyclosporine- and FK506-induced sympathetic activation correlates with calcineurin-mediated inhibition of T-cell signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

Adjusting immunosuppression to the identification of T-cell activating mediators in rejecting transplants: a novel approach to rejection diagnosis and treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

The effect of rapamycin on kidney function in the Sprague-Dawley rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2803%2900211-2

7 January 2021

17

99

2094

Javier

1997

1 reference

https://api.crossref.org/works/10.1016/S0041-1345(03)00211-2

Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation

1 January 2024

series ordinal

26

1 reference

https://api.crossref.org/works/10.1016/S0041-1345(03)00211-2

1 January 2024

Identifiers

1 reference

6 August 2017

1 reference

PubMed ID

12742462