A mutation in the heterotrimeric stimulatory guanine nucleotide binding protein alpha-subunit with impaired receptor-mediated activation because of elevated GTPase activity. (Q35123471)

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English	A mutation in the heterotrimeric stimulatory guanine nucleotide binding protein alpha-subunit with impaired receptor-mediated activation because of elevated GTPase activity.	scientific article

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4 December 2019

A mutation in the heterotrimeric stimulatory guanine nucleotide binding protein alpha-subunit with impaired receptor-mediated activation because of elevated GTPase activity (English)

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4 December 2019

Lee S. Weinstein

2

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4 December 2019

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D R Warner

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1 April 1999

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4 December 2019

Proceedings of the National Academy of Sciences of the United States of America

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4 December 2019

96

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4 December 2019

8

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4 December 2019

4268-4272

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4 December 2019

Mutagenesis of the conserved residue Glu259 of Gsalpha demonstrates the importance of interactions between switches 2 and 3 for activation

1 reference

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9 July 2018

A novel mutation in the switch 3 region of Gsalpha in a patient with Albright hereditary osteodystrophy impairs GDP binding and receptor activation

1 reference

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9 July 2018

G-protein diseases furnish a model for the turn-on switch

1 reference

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9 July 2018

Mammalian RGS proteins: barbarians at the gate

1 reference

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9 July 2018

Crystal structure of the adenylyl cyclase activator Gsalpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

9 July 2018

A novel mutation adjacent to the switch III domain of G(S alpha) in a patient with pseudohypoparathyroidism

1 reference

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9 July 2018

Communication between switch II and switch III of the transducin alpha subunit is essential for target activation

1 reference

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9 July 2018

Inhibition of an inwardly rectifying K+ channel by G-protein alpha-subunits.

1 reference

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9 July 2018

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

9 July 2018

The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

9 July 2018

Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein

1 reference

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9 July 2018

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

9 July 2018

Rapid GDP release from Gs alpha in patients with gain and loss of endocrine function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

9 July 2018

Heterotrimeric G proteins: organizers of transmembrane signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

9 July 2018

Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis

1 reference

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9 July 2018

The regulatory component of adenylate cyclase. Purification and properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

9 July 2018

A mutation that prevents GTP-dependent activation of the alpha chain of Gs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

9 July 2018

Isolation and characterization of the human Gs alpha gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

9 July 2018

The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

9 July 2018

GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

9 July 2018

Synthesis in Escherichia coli of GTPase-deficient mutants of Gs alpha.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

9 July 2018

Receptor and effector interactions of Gs. Functional studies with antibodies to the alpha s carboxyl-terminal decapeptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

9 July 2018

A G protein directly regulates mammalian cardiac calcium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

9 July 2018

Receptor-effector coupling by G proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

9 July 2018

Two G protein oncogenes in human endocrine tumors

1 reference

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9 July 2018

Activating mutations of the stimulatory G protein in the McCune-Albright syndrome

1 reference

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9 July 2018

Substitution of aspartic acid-80, a residue involved in coordination of magnesium, weakens the GTP binding and strongly enhances the GTPase of the G domain of elongation factor Tu

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

9 July 2018

Receptor-effector coupling by G proteins: implications for normal and abnormal signal transduction

1 reference

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9 July 2018

Receptor-mediated activation of Gsalpha: evidence for intramolecular signal transduction.

1 reference

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27 September 2018

Mutations at the domain interface of GSalpha impair receptor-mediated activation by altering receptor and guanine nucleotide binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

27 September 2018

Role of glutamine-61 in the hydrolysis of GTP by p21H-ras: an experimental and theoretical study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

27 September 2018

Guanosine 5'-(gamma-thio)triphosphate binding assay for solubilized G proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

27 September 2018

Expression of G-protein alpha subunits in Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16321

27 September 2018

The G-protein nanomachine

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.8.4268

21 January 2018

Identifiers

10.1073/PNAS.96.8.4268

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4 December 2019

1999PNAS...96.4268W

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1 reference

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4 December 2019

1 reference

Europe PubMed Central

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4 December 2019

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