Molecular interactions of ‘high risk’ human papillomaviruses E6 and E7 oncoproteins: implications for tumour progression (Q35122647)

6 August 2017

1 reference

title

Molecular interactions of 'high risk' human papillomaviruses E6 and E7 oncoproteins: implications for tumour progression (English)

1 reference

6 August 2017

Molecular interactions of ‘high risk’ human papillomaviruses E6 and E7 oncoproteins: implications for tumour progression (English)

1 reference

31 December 2023

main subject

molecular interaction

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12734411

31 December 2023

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Oishee Chakrabarti

1

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6 August 2017

Sudhir Krishna

series ordinal

2

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6 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12734411

31 December 2023

publication date

1 April 2003

1 reference

full work available at URL

6 August 2017

http://link.springer.com/content/pdf/10.1007/BF02970152.pdf

file format

Portable Document Format

1 reference

http://link.springer.com/article/10.1007/BF02970152/fulltext.html

31 December 2023

1 reference

http://link.springer.com/content/pdf/10.1007/BF02970152

31 December 2023

1 reference

31 December 2023

published in

Journal of Biosciences

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6 August 2017

28

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6 August 2017

3

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6 August 2017

337-348

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https://scigraph.springernature.com/pub.10.1007/bf02970152

6 August 2017

0 references

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The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation

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Natural history of cervical neoplasia: consistent results obtained by an identification technique

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Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein

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Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins

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The G(2) checkpoint is maintained by redundant pathways

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Transcriptional activation by NF-kappaB requires multiple coactivators

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Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines

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Human papillomavirus (HPV) E6 interactions with Bak are conserved amongst E6 proteins from high and low risk HPV types

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Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1.

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Inhibition of Bak-induced apoptosis by HPV-18 E6.

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12 December 2020

Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein

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12 December 2020

The transcriptional coactivators p300 and CBP are histone acetyltransferases

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12 December 2020

The regulation of E2F by pRB-family proteins

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12 December 2020

Targeting of transcriptional cofactors by the HPV E6 protein: another tale of David and Goliath

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12 December 2020

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

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12 December 2020

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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12 December 2020

Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein

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12 December 2020

Telomeres shorten during ageing of human fibroblasts

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12 December 2020

Allosteric activation of acid alpha-glucosidase by the human papillomavirus E7 protein

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12 December 2020

Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas.

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Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

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Intracellular surveillance of persisting viral infections. Human genital cancer results from deficient cellular control of papillomavirus gene expression

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RNA helicase A mediates association of CBP with RNA polymerase II

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12 December 2020

Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein

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12 December 2020

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

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12 December 2020

Persistent Genital Human Papillomavirus Infection as a Risk Factor for Persistent Cervical Dysplasia

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12 December 2020

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

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12 December 2020

Transforming growth factor-alpha-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation.

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12 December 2020

Proteasome-mediated regulation of the hDlg tumour suppressor protein.

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12 December 2020

Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells.

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12 December 2020

The human papillomavirus E7 protein as a transforming and transactivating factor

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12 December 2020

The E7 protein of human papillomavirus type 16 sensitizes primary human keratinocytes to apoptosis

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12 December 2020

Interaction of oncogenic papillomavirus E6 proteins with fibulin-1

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12 December 2020

Cellular proteins that are targetted by DNA tumor viruses for transformation

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12 December 2020

Analysis of the interaction between human papillomavirus type 16 E7 and the TATA-binding protein, TBP

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12 December 2020

HPV E6 targeted degradation of the discs large protein: evidence for the involvement of a novel ubiquitin ligase

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Cancer. p53, guardian of the genome

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Histone acetylation in chromatin structure and transcription

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12 December 2020

The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300.

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12 December 2020

The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein.

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12 December 2020

Papillomaviruses in anogenital cancer as a model to understand the role of viruses in human cancers

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12 December 2020

Rb binds c-Jun and activates transcription

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12 December 2020

HPV-16 E7 and adenovirus E1a complex formation with TATA box binding protein is enhanced by casein kinase II phosphorylation

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12 December 2020

Characterisation of the paxillin-binding site and the C-terminal focal adhesion targeting sequence in vinculin

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12 December 2020

Identification of a novel retinoblastoma gene product binding site on human papillomavirus type 16 E7 protein

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12 December 2020

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

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12 December 2020

Human papillomavirus oncoproteins alter differentiation-dependent cell cycle exit on suspension in semisolid medium

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12 December 2020

The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth

1 reference

12 December 2020

HPV16 E7 protein associates with the protein kinase p33CDK2 and cyclin A

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12 December 2020

Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity

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12 December 2020

Cellular immunodeficiency enhances the progression of human papillomavirus-associated cervical lesions

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12 December 2020

Expression of the human papillomavirus E7 oncogene during cell transformation is sufficient to induce susceptibility to lysis by activated macrophages

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12 December 2020

The viral oncoproteins Ad5 E1A, HPV16 E7 and SV40 TAg bind a common region of the TBP-associated factor-110.

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12 December 2020

The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors

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12 December 2020

Transactivation of prothymosin alpha and c-myc promoters by human papillomavirus type 16 E6 protein

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12 December 2020

Inducible and constitutive enhancer domains in the noncoding region of human papillomavirus type 18

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12 December 2020

Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death.

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12 December 2020

The natural history of cervical intraepithelial neoplasia: an argument for intermediate endpoint biomarkers

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12 December 2020

Activation of the focal adhesion kinase signal transduction pathway in cervical carcinoma cell lines and human genital epithelial cells immortalized with human papillomavirus type 18

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12 December 2020

Telomere length regulation

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12 December 2020

The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein

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12 December 2020

Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation

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12 December 2020

Synergistic activation of transcription by CBP and p53

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12 December 2020

The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton.

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12 December 2020

CDK inhibitors: positive and negative regulators of G1-phase progression

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12 December 2020

Initiation of DNA synthesis by human papillomavirus E7 oncoproteins is resistant to p21-mediated inhibition of cyclin E-cdk2 activity

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12 December 2020

Specific association of human telomerase activity with immortal cells and cancer

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12 December 2020

Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene.

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12 December 2020

Disruption of the G1/S transition in human papillomavirus type 16 E7-expressing human cells is associated with altered regulation of cyclin E

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12 December 2020

The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity

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12 December 2020

The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-alpha

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12 December 2020

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12 December 2020

Anchorage-independent transcription of the cyclin A gene induced by the E7 oncoprotein of human papillomavirus type 16.

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12 December 2020

Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo

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12 December 2020

The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals

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12 December 2020

Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genes.

1 reference

12 December 2020

The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.

1 reference

12 December 2020

The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.

1 reference

12 December 2020

The CBP co-activator is a histone acetyltransferase

1 reference

12 December 2020

Telomerase activation by the E6 gene product of human papillomavirus type 16.

1 reference

12 December 2020

Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

1 reference

12 December 2020

Increased E6/E7 transcription in HPV 18-immortalized human keratinocytes results from inactivation of E2 and additional cellular events

1 reference

12 December 2020

Human papillomavirus type 16 and 18 gene expression in cervical neoplasias

1 reference

12 December 2020

Human papillomavirus type 16 E6-induced degradation of E6TP1 correlates with its ability to immortalize human mammary epithelial cells

1 reference

12 December 2020

Oncogenes and tumor angiogenesis: the HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent manner

1 reference

12 December 2020

Human papillomavirus type 16 E7 oncoprotein binds and inactivates growth-inhibitory insulin-like growth factor binding protein 3

1 reference

12 December 2020

The molecular biology of cervical cancer

1 reference

12 December 2020

The E7 open reading frame of human papillomavirus type 16 encodes a transforming gene.

1 reference

12 December 2020

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1 reference

12 December 2020

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product

1 reference

12 December 2020

Papillomaviruses and cancer: from basic studies to clinical application

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12 December 2020

The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300.

1 reference

12 December 2020

Human papillomavirus E6 and E7: proteins which deregulate the cell cycle

1 reference

12 December 2020

The HPV E7 oncoprotein inhibits tumor necrosis factor alpha-mediated apoptosis in normal human fibroblasts

1 reference

12 December 2020

Regulation of type I interferon gene expression by interferon regulatory factor-3.

1 reference

12 December 2020

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

1 reference

12 December 2020

Cellular transformation by papillomavirus oncoproteins

1 reference

12 December 2020

The E6-E7 region of human papillomavirus type 18 is sufficient for transformation of NIH 3T3 and rat-1 cells

1 reference

12 December 2020

Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins

1 reference

12 December 2020

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1 reference

12 December 2020

HPV16 E6 oncoprotein stimulates the transforming growth factor-beta 1 promoter in fibroblasts through a specific GC-rich sequence

1 reference

12 December 2020

The human papillomavirus type 16 E6 and E7 oncoproteins dissociate cellular telomerase activity from the maintenance of telomere length

1 reference

12 December 2020

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

1 reference

12 December 2020

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein

1 reference

12 December 2020

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

1 reference

12 December 2020

Human papillomavirus type 16 transformation of primary human embryonic fibroblasts requires expression of open reading frames E6 and E7

1 reference

12 December 2020

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1 reference

12 December 2020

Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins

1 reference

12 December 2020

Elevated wild-type p53 protein levels in human epithelial cell lines immortalized by the human papillomavirus type 16 E7 gene

1 reference

12 December 2020

The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.

1 reference

12 December 2020

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1 reference

12 December 2020

Relative enhancer activity and transforming potential of authentic human papillomavirus type 6 genomes from benign and malignant lesions

1 reference

12 December 2020

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

1 reference

12 December 2020

Inhibition of E6 induced degradation of p53 is not sufficient for stabilization of p53 protein in cervical tumour derived cell lines

1 reference

12 December 2020

Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase

1 reference

12 December 2020

The E6 and E7 genes of HPV-18 are sufficient for inducing two-stage in vitro transformation of human keratinocytes

1 reference

12 December 2020

Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes

1 reference

12 December 2020

Activated Notch1 signaling cooperates with papillomavirus oncogenes in transformation and generates resistance to apoptosis on matrix withdrawal through PKB/Akt

1 reference

12 December 2020

Nuclear protein CBP is a coactivator for the transcription factor CREB

1 reference

12 December 2020

Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP

1 reference

12 December 2020

Retinoblastoma protein recruits histone deacetylase to repress transcription

1 reference

12 December 2020

Natural history of cervical intraepithelial neoplasia: a critical review.

1 reference

12 December 2020

Genital papillomavirus infections

1 reference

12 December 2020

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha

1 reference

12 December 2020

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Identifiers

DOI

10.1007/BF02970152

1 reference

6 August 2017

1 reference