Reaction mechanism and regulation of cystathionine beta-synthase (Q35103507)

6 August 2017

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title

Reaction mechanism and regulation of cystathionine beta-synthase (English)

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6 August 2017

Ruma Banerjee

1

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6 August 2017

Ruby Evande

2

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6 August 2017

Omer Kabil

3

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6 August 2017

Sunil Ojha

4

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6 August 2017

Shin Taoka

5

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6 August 2017

language of work or name

English

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publication date

1 April 2003

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Biochimica et Biophysica Acta

6 August 2017

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6 August 2017

1647

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6 August 2017

30-35

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6 August 2017

1-2

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The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Yeast cystathionine beta-synthase is a pyridoxal phosphate enzyme but, unlike the human enzyme, is not a heme protein

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Correction of disease-causing CBS mutations in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Delta-aminolevulinate increases heme saturation and yield of human cystathionine beta-synthase expressed in Escherichia coli.

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Homocysteine and cardiovascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Homocysteine metabolism in pregnancies complicated by neural-tube defects.

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Cystathionine beta-synthase mutations in homocystinuria

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Trypsin cleavage of human cystathionine beta-synthase into an evolutionarily conserved active core: structural and functional consequences.

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Assignment of enzymatic functions to specific regions of the PLP-dependent heme protein cystathionine beta-synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

The structure of a domain common to archaebacteria and the homocystinuria disease protein

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Domain architecture of the heme-independent yeast cystathionine beta-synthase provides insights into mechanisms of catalysis and regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Mutations in the regulatory domain of cystathionine beta synthase can functionally suppress patient-derived mutations in cis.

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Binding of pyridoxal 5'-phosphate to the heme protein human cystathionine beta-synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Stopped-flow kinetic analysis of the reaction catalyzed by the full-length yeast cystathionine beta-synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

The reaction of yeast cystathionine beta-synthase is rate-limited by the conversion of aminoacrylate to cystathionine

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Hemoprotein H-450 Identified as a Form of Cytochrome P-450 Having an Endogenous Ligand at the 6th Coordination Position of the Heme

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Characterization of the heme in human cystathionine beta-synthase by X-ray absorption and electron paramagnetic resonance spectroscopies

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Resonance Raman characterization of the heme cofactor in cystathionine beta-synthase. Identification of the Fe-S(Cys) vibration in the six-coordinate low-spin heme

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Effects of heme ligand mutations including a pathogenic variant, H65R, on the properties of human cystathionine beta-synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Characterization of NO binding to human cystathionine beta-synthase: possible implications of the effects of CO and NO binding to the human enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Mercuric chloride-induced spin or ligation state changes in ferric or ferrous human cystathionine beta-synthase inhibit enzyme activity

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine beta-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Activation of cystathionine synthase by adenosylmethionine and adenosylethionine

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Alleviation of intrasteric inhibition by the pathogenic activation domain mutation, D444N, in human cystathionine beta-synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Defective cystathionine beta-synthase regulation by S-adenosylmethionine in a partially pyridoxine responsive homocystinuria patient.

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900044-X

7 January 2021

10.1016/S1570-9639(03)00044-X

Identifiers

DOI

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6 August 2017

1 reference