Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis (Q35102293)

6 August 2017

Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis (English)

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6 August 2017

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7

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Lucia Musumeci

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Marijke J Kuijpers

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Alexandre Hego

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Emilie Théâtre

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Marc Thiry

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Michel Moutschen

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language of work or name

English

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publication date

17 December 2014

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6 August 2017

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11 June 2020

volume

131

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page(s)

656-668

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issue

7

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DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase

11 June 2020

cites work

1 reference

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9 July 2018

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Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome"

9 July 2018

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Inhibition of the Hematopoietic Protein Tyrosine Phosphatase by Phenoxyacetic Acids

9 July 2018

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Development of a Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure

9 July 2018

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Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling

9 July 2018

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Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.

9 July 2018

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Roles of platelet STIM1 and Orai1 in glycoprotein VI- and thrombin-dependent procoagulant activity and thrombus formation

9 July 2018

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Antiplatelet therapies for the treatment of cardiovascular disease

9 July 2018

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Multidentate Small-Molecule Inhibitors of Vaccinia H1-Related (VHR) Phosphatase Decrease Proliferation of Cervix Cancer Cells

9 July 2018

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The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis

9 July 2018

1 reference

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The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer

9 July 2018

1 reference

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Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR

9 July 2018

1 reference

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Discovery of VHR phosphatase inhibitors with micromolar activity based on structure-based virtual screening

9 July 2018

1 reference

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Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation

9 July 2018

1 reference

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Regulation of MAP kinases by the VHR dual-specific phosphatase: implications for cell growth and differentiation

9 July 2018

1 reference

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Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence

9 July 2018

1 reference

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Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo

9 July 2018

1 reference

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GPVI and integrin alphaIIb beta3 signaling in platelets

9 July 2018

1 reference

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Protein tyrosine phosphatases in the human genome

9 July 2018

1 reference

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Overexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotype

9 July 2018

1 reference

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A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo

9 July 2018

1 reference

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P2X(1)-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagen

9 July 2018

1 reference

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Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen

9 July 2018

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

9 July 2018

1 reference

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Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor gamma chain complex on human platelets

9 July 2018

1 reference

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Expression cloning of a human dual-specificity phosphatase

9 July 2018

1 reference

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Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice.

9 July 2018

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27 September 2018

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Key role of platelet procoagulant activity in tissue factor-and collagen-dependent thrombus formation in arterioles and venules in vivo differential sensitivity to thrombin inhibition

27 September 2018

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Identification of a potent inhibitor of human dual-specific phosphatase, VHR, from computer-aided and NMR-based screening to cellular effects.

27 September 2018

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GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism

27 September 2018

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The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion

27 September 2018

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4-isoavenaciolide covalently binds and inhibits VHR, a dual-specificity phosphatase.

27 September 2018

1 reference

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Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: implications for the molecular mechanism of the inhibition

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334727

Platelet adhesion enhances the glycoprotein VI-dependent procoagulant response: Involvement of p38 MAP kinase and calpain

27 September 2018

1 reference

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CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis

27 September 2018

1 reference

12 December 2020

Platelet Glycoprotein VI Dimerization, an Active Process Inducing Receptor Competence, Is an Indicator of Platelet Reactivity

1 reference

12 December 2020

Platelets activated by collagen through immunoreceptor tyrosine-based activation motif play pivotal role in initiation and generation of neointimal hyperplasia after vascular injury

1 reference

12 December 2020

The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen

1 reference

12 December 2020

The physiological and pathophysiological roles of platelet CLEC-2

1 reference

12 December 2020

10.1161/CIRCULATIONAHA.114.010186

Identifiers

DOI

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11 June 2020

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11 June 2020

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