Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA (Q35101167)

6 August 2017

title

Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA (English)

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6 August 2017

Yury S Polikanov

1

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author name string

Teresa Szal

2

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6 August 2017

Fuyan Jiang

3

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6 August 2017

Pulkit Gupta

4

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6 August 2017

Ryoichi Matsuda

5

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6 August 2017

Masataka Shiozuka

6

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6 August 2017

Thomas A Steitz

7

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6 August 2017

Nora Vázquez-Laslop

8

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6 August 2017

Alexander S Mankin

9

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6 August 2017

publication date

9 October 2014

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6 August 2017

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6 August 2017

volume

56

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6 August 2017

issue

4

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6 August 2017

page(s)

541-550

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Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome

6 August 2017

cites work

1 reference

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A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome

9 July 2018

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Negamycin analogue with readthrough-promoting activity as a potential drug candidate for duchenne muscular dystrophy

9 July 2018

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Tools for characterizing bacterial protein synthesis inhibitors

9 July 2018

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Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

9 July 2018

1 reference

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Structural basis for TetM-mediated tetracycline resistance

9 July 2018

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How Hibernation Factors RMF, HPF, and YfiA Turn Off Protein Synthesis

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

The structure of the eukaryotic ribosome at 3.0 Å resolution

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Readthrough of premature termination codons in the adenomatous polyposis coli gene restores its biological activity in human cancer cells

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Differential effects of thiopeptide and orthosomycin antibiotics on translational GTPases

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

The A-Z of bacterial translation inhibitors

9 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Nonoptimal microbial response to antibiotics underlies suppressive drug interactions

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Structural basis for translation termination on the 70S ribosome

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Drug-induced readthrough of premature stop codons leads to the stabilization of laminin alpha2 chain mRNA in CMD myotubes

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

A Steric Block in Translation Caused by the Antibiotic Spectinomycin

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Negamycin Binds to the Wall of the Nascent Chain Exit Tunnel of the 50S Ribosomal Subunit

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Structural basis for aminoglycoside inhibition of bacterial ribosome recycling

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Structural insights into translational fidelity

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

16S rRNA mutations that confer tetracycline resistance in Helicobacter pylori decrease drug binding in Escherichia coli ribosomes

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Effects of 16S rRNA gene mutations on tetracycline resistance in Helicobacter pylori

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Atomic structures of the 30S subunit and its complexes with ligands and antibiotics

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Structural basis for the antibiotic activity of ketolides and azalides

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Emergence of tetracycline resistance in Helicobacter pylori: multiple mutational changes in 16S ribosomal DNA and other genetic loci

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

16S rRNA mutation-mediated tetracycline resistance in Helicobacter pylori

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Localization of the ribosomal protection protein Tet(O) on the ribosome and the mechanism of tetracycline resistance

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Determinants of aminoglycoside-binding specificity for rRNA by using mass spectrometry

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

An Escherichia coli strain with all chromosomal rRNA operons inactivated: complete exchange of rRNA genes between bacteria

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

16S rRNA mutation associated with tetracycline resistance in a gram-positive bacterium

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

In vivo deuteration of transfer RNAs: overexpression and large-scale purification of deuterated specific tRNAs

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

A new antibiotic, negamycin

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Mechanism of action of negamycin in Escherichia coli K12. II. Miscoding activity in polypeptide synthesis directed by snythetic polynucleotide

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Mechanism of action of negamycin in Escherichia coli K12. I. Inhibition of initiation of protein synthesis

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Negamycin, a miscoding antibiotic with a unique structure

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Defining the structural requirements for a helix in 23 S ribosomal RNA that confers erythromycin resistance.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Extension inhibition analysis of translation initiation complexes

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Reverse translocation of tRNA in the ribosome.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Conformational changes of the small ribosomal subunit during elongation factor G-dependent tRNA-mRNA translocation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

tRNA selection and kinetic proofreading in translation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Negamycin restores dystrophin expression in skeletal and cardiac muscles of mdx mice

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Conformational changes in the ribosome induced by translational miscoding agents.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Resistance to the peptide-like antibiotic negamycin in Escherichia coli.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

The Geometry of the Ribosomal Polypeptide Exit Tunnel

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334386

Structure-activity relationships among negamycin analogs

8 December 2018

1 reference

12 December 2020

Negamycin inhibits termination of protein synthesis directed by phage f2 RNA in vitro

1 reference

12 December 2020

Dissociation rate of cognate peptidyl-tRNA from the A-site of hyper-accurate and error-prone ribosomes

1 reference

12 December 2020

Specific inhibition of the termination process of protein synthesis by negamycin

1 reference

12 December 2020

Interactions of a small RNA with antibiotic and RNA ligands of the 30S subunit

1 reference

12 December 2020

Crystallization and preliminary X-ray analysis of Escherichia coli methionyl-tRNAMet(f) formyltransferase complexed with formyl-methionyl-tRNAMet(f)

1 reference

12 December 2020

10.1016/J.MOLCEL.2014.09.021

Identifiers

DOI

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6 August 2017

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6 August 2017

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