Bioenergetics breakdown in Alzheimer's disease: targets for new therapies (Q35098445)

6 August 2017

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title

Bioenergetics breakdown in Alzheimer's disease: targets for new therapies (English)

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6 August 2017

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Uday Saxena

1

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6 August 2017

publication date

12 June 2010

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International journal of physiology, pathophysiology and pharmacology

6 August 2017

published in

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6 August 2017

volume

3

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6 August 2017

issue

2

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6 August 2017

page(s)

133-139

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Progress in the development of beta-secretase inhibitors for Alzheimer's disease

6 August 2017

cites work

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Is Brain Amyloid Production a Cause or a Result of Dementia of The Alzheimer's Type?

9 July 2018

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Multiple Defects in Energy Metabolism in Alzheimers Disease

9 July 2018

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9 July 2018

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9 July 2018

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NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death

9 July 2018

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The secretases: enzymes with therapeutic potential in Alzheimer disease

9 July 2018

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Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

9 July 2018

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Oxidative stress in diabetes and Alzheimer's disease

9 July 2018

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Glycogen synthase kinase 3: more than a namesake

9 July 2018

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FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease

9 July 2018

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Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

9 July 2018

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Hypometabolism as a therapeutic target in Alzheimer's disease

9 July 2018

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Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease

9 July 2018

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Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease

9 July 2018

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Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease

9 July 2018

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Promotion of cellular NAD(+) anabolism: therapeutic potential for oxidative stress in ageing and Alzheimer's disease.

9 July 2018

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BACE inhibitors as potential therapeutics for Alzheimer's disease

9 July 2018

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The role of GSK3 in glucose homeostasis and the development of insulin resistance

9 July 2018

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Lipoic acid as a novel treatment for Alzheimer's disease and related dementias.

9 July 2018

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Mitoenergetic failure in Alzheimer disease

9 July 2018

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Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

9 July 2018

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Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD.

9 July 2018

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Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes

9 July 2018

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Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134007

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

9 July 2018

1 reference

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Alzheimer's disease: genes, proteins, and therapy

9 July 2018

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Possible role of tau protein kinases in pathogenesis of Alzheimer's disease.

9 July 2018

1 reference

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Amyloid, the presenilins and Alzheimer's disease

9 July 2018

1 reference

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Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain

9 July 2018

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Changes in Na+,K(+)-ATPase, Ca2(+)-ATPase and some soluble enzymes related to energy metabolism in brains of patients with Alzheimer's disease.

9 July 2018

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Alzheimer's disease amyloid hypothesis at crossroads: where do we go from here?

9 July 2018

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A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo.

27 September 2018

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Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial

27 September 2018

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Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134007

Abnormalities of mitochondrial enzymes in Alzheimer disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134007

Phosphofructokinase activity in the brain in Alzheimer's disease

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21760971

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

PMC publication ID

3134007

1 reference

6 August 2017

1 reference