Systemic delivery of siRNA down regulates brain prion protein and ameliorates neuropathology in prion disorder. (Q35097571)

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8 March 2020

title

Systemic delivery of siRNA down regulates brain prion protein and ameliorates neuropathology in prion disorder (English)

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8 March 2020

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10

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Constance Delaby

11

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8 March 2020

Carole Crozet

17

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author name string

Aroa Relano-Gines

2

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Sarah Resina

3

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Elsa Brillaud

4

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Danielle Casanova

5

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Charles Vincent

6

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Claire Hamela

7

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Sophie Poupeau

8

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Mathieu Laffont

9

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Maxime Belondrade

12

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Jacques-Damien Arnaud

13

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Maria-Teresa Alvarez

14

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Jean-Claude Maurel

15

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Patrick Maurel

16

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8 March 2020

Sylvain Lehmann

1

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8 March 2020

language of work or name

English

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publication date

14 February 2014

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8 March 2020

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8 March 2020

volume

9

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issue

2

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8 March 2020

page(s)

e88797

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Creative Commons Attribution 4.0 International

8 March 2020

copyright license

start time

14 February 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Human prion diseases: from Kuru to variant Creutzfeldt-Jakob disease

1 reference

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Molecular pathology, classification, and diagnosis of sporadic human prion disease variants.

9 July 2018

1 reference

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The origin and metabolism of a nascent pre-β high density lipoprotein involved in cellular cholesterol efflux

9 July 2018

1 reference

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Liposome-siRNA-peptide complexes cross the blood-brain barrier and significantly decrease PrP on neuronal cells and PrP in infected cell cultures

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925167

RNAi for the treatment of prion disease: a window for intervention in neurodegeneration?

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925167

Therapy for prion diseases: Insights from the use of RNA interference.

9 July 2018

1 reference

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Gene and cell therapy for prion diseases.

9 July 2018

1 reference

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Effective gene therapy in a mouse model of prion diseases

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925167

Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease

9 July 2018

1 reference

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Lessons from Nature: microRNA-based shRNA libraries

9 July 2018

1 reference

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Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925167

Rational targeting for prion therapeutics.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925167

Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925167

9 July 2018

1 reference

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Mice devoid of PrP are resistant to scrapie

9 July 2018

1 reference

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Novel proteinaceous infectious particles cause scrapie

9 July 2018

1 reference

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NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease

9 July 2018

1 reference

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Stem cell therapy extends incubation and survival time in prion-infected mice in a time window-dependant manner.

27 September 2018

1 reference

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An historical perspective on efforts to treat transmissible spongiform encephalopathy.

27 September 2018

1 reference

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Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice.

27 September 2018

1 reference

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Lipoprotein profiles in plasma and interstitial fluid analyzed with an automated gel-filtration system

27 September 2018

1 reference

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No propagation of prions in mice devoid of PrP.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925167

10.1371/JOURNAL.PONE.0088797

27 September 2018

Identifiers

DOI

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8 March 2020

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8 March 2020

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