The enigmatic role of the hemochromatosis protein (HFE) in iron absorption (Q35092299)

6 August 2017

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title

The enigmatic role of the hemochromatosis protein (HFE) in iron absorption (English)

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6 August 2017

Michael J Chorney

1

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6 August 2017

Yukinori Yoshida

2

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6 August 2017

Paul N Meyer

3

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6 August 2017

Mika Yoshida

4

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6 August 2017

Glenn S Gerhard

5

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6 August 2017

1 March 2003

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Trends in Molecular Medicine

6 August 2017

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6 August 2017

9

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6 August 2017

3

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6 August 2017

118-125

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Hemochromatosis: the genetic disorder of the twenty-first century

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Physiology of iron transport and the hemochromatosis gene.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

How little we know about the absorption of iron

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Hallmarks of hypochromic anemias

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Mechanisms of iron accumulation in hereditary hemochromatosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

An iron-regulated ferric reductase associated with the absorption of dietary iron

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

1 reference

7 January 2021

The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

A novel mammalian iron-regulated protein involved in intracellular iron metabolism

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Gamma delta intraepithelial lymphocytes drive tumor necrosis factor-alpha responsiveness to intestinal iron challenge: relevance to hemochromatosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

The major histocompatibility complex-encoded HFE in iron homeostasis and immune function

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Regulation of transferrin, transferrin receptor, and ferritin genes in human duodenum

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Hemochromatosis protein (HFE) and tumor necrosis factor receptor 2 (TNFR2) influence tissue iron levels: elements of a common gut pathway?

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Intestinal expression of genes involved in iron absorption in humans

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Iron homeostasis: insights from genetics and animal models

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Duodenal metal-transporter (DMT-1, NRAMP-2) expression in patients with hereditary haemochromatosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Intestinal iron uptake determined by divalent metal transporter is enhanced in HFE-deficient mice with hemochromatosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa. Possible implications for the regulation of iron absorption

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Kupffer cell staining by an HFE-specific monoclonal antibody: implications for hereditary haemochromatosis.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Iron overload in mice expressing HFE exclusively in the intestinal villi provides evidence that HFE regulates a functional cross-talk between crypt and villi enterocytes

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Overexpression of the hereditary hemochromatosis protein, HFE, in HeLa cells induces an iron-deficient phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: implications for cellular iron homeostasis

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Overexpression of hemochromatosis protein, HFE, alters transferrin recycling process in human hepatoma cells

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

HFE inhibits apical iron uptake by intestinal epithelial (Caco-2) cells

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

The hemochromatosis protein HFE inhibits iron export from macrophages.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

The major histocompatibility complex-encoded class I-like HFE abrogates endocytosis of transferrin receptor by inducing receptor phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Interactions of the ectodomain of HFE with the transferrin receptor are critical for iron homeostasis in cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Iron and immunity: a double-edged sword.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Iron overload in β2-microglobulin-deficient mice

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

129X1/SvJ mouse strain has a novel defect in inflammatory cell recruitment.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Human cytomegalovirus protein US2 interferes with the expression of human HFE, a nonclassical class I major histocompatibility complex molecule that regulates iron homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Modulation of epithelial cell growth by intraepithelial gamma delta T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Role for NF-kappa B in the regulation of ferritin H by tumor necrosis factor-alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Associations between cellular immune effector function, iron metabolism, and disease activity in patients with chronic hepatitis C virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Experimental hemochromatosis due to MHC class I HFE deficiency: immune status and iron metabolism

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Regulation of iron absorption in Hfe mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Nramp1 modulates iron homoeostasis in vivo and in vitro: evidence for a role in cellular iron release involving de-acidification of intracellular vesicles

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Iron metabolism in mammalian cells

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNA

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

Molecular aspects of iron absorption and HFE expression

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900023-6

7 January 2021

10.1016/S1471-4914(03)00023-6

Identifiers

DOI

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6 August 2017

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