Inhibition of signal transduction by the nm23 metastasis suppressor: possible mechanisms (Q35089906)

6 August 2017

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title

Inhibition of signal transduction by the nm23 metastasis suppressor: possible mechanisms (English)

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6 August 2017

4

Patricia S Steeg

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6 August 2017

Massimiliano Salerno

1

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6 August 2017

Taoufik Ouatas

series ordinal

2

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6 August 2017

Diane Palmieri

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3

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6 August 2017

1 January 2003

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Clinical & Experimental Metastasis

6 August 2017

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6 August 2017

20

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6 August 2017

3-10

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6 August 2017

1

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https://scigraph.springernature.com/pub.10.1023/a:1022578000022

6 August 2017

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cites work

Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression

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12 December 2020

Phospholipase D2 directly interacts with aldolase via Its PH domain

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12 December 2020

Nucleoside-diphosphate kinase-mediated signal transduction via histidyl-aspartyl phosphorelay systems in Escherichia coli.

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12 December 2020

Suppression of human melanoma metastasis following introduction of chromosome 6 is independent of NME1 (Nm23).

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12 December 2020

Menin, a gene product responsible for multiple endocrine neoplasia type 1, interacts with the putative tumor metastasis suppressor nm23

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12 December 2020

Quaternary structure of nucleoside diphosphate kinases

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12 December 2020

Thiophosphorylation of the G protein beta subunit in human platelet membranes: evidence against a direct phosphate transfer reaction to G alpha subunits

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12 December 2020

Evidence for complex formation between GTP binding protein(Gs) and membrane-associated nucleoside diphosphate kinase

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12 December 2020

Molecular consequences of awdb3, a cell-autonomous lethal mutation of Drosophila induced by hybrid dysgenesis

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12 December 2020

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

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12 December 2020

Association of nucleoside diphosphate kinase nm23-H2 with human telomeres

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12 December 2020

Overexpression of nucleoside diphosphate kinases induces neurite outgrowth and their substitution to inactive forms leads to suppression of nerve growth factor- and dibutyryl cyclic AMP-induced effects in PC12D cells

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12 December 2020

Epstein-Barr virus nuclear protein EBNA-3C interacts with the human metastatic suppressor Nm23-H1: a molecular link to cancer metastasis

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12 December 2020

The protein kinase KSR interacts with 14-3-3 protein and Raf.

1 reference

12 December 2020

Nm23/PuF does not directly stimulate transcription through the CT element in vivo

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12 December 2020

Reduced metastatic potential and c-myc overexpression of colon adenocarcinoma cells (Colon 26 line) transfected with nm23-R2/rat nucleoside diphosphate kinase alpha isoform

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12 December 2020

Reproductive state of rat mammary gland stroma modulates human breast cancer cell migration and invasion

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12 December 2020

The human Nm23/nucleoside diphosphate kinases

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12 December 2020

Overexpression of nm23-H2/NDP kinase B in a human oral squamous cell carcinoma cell line results in reduced metastasis, differentiated phenotype in the metastatic site, and growth factor-independent proliferative activity in culture

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12 December 2020

A favorable impact of preoperative FPLC chemotherapy on patients with gastric cardia cancer

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12 December 2020

Wild-type NM23-H1, but not its S120 mutants, suppresses desensitization of muscarinic potassium current

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12 December 2020

Two isotypes of murine nm23/nucleoside diphosphate kinase, nm23-M1 and nm23-M2, are involved in metastatic suppression of a murine melanoma line

1 reference

12 December 2020

Evidence for nm23 RNA overexpression, DNA amplification and mutation in aggressive childhood neuroblastomas.

1 reference

12 December 2020

Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells

1 reference

12 December 2020

Cytoskeletal association of the A and B nucleoside diphosphate kinases of interphasic but not mitotic human carcinoma cell lines: specific nuclear localization of the B subunit

1 reference

12 December 2020

Relationship of nm23 to proteolytic factors, proliferation and motility in breast cancer tissues and cell lines

1 reference

12 December 2020

A new function of Nm23/NDP kinase as a differentiation inhibitory factor, which does not require it's kinase activity

1 reference

12 December 2020

NM23-H1 and NM23-H2 repress transcriptional activities of nuclease-hypersensitive elements in the platelet-derived growth factor-A promoter

1 reference

12 December 2020

KSR, a novel protein kinase required for RAS signal transduction

1 reference

12 December 2020

Increased sensitivity to cisplatin by nm23-transfected tumor cell lines

1 reference

12 December 2020

Histidine to aspartate phosphotransferase activity of nm23 proteins: phosphorylation of aldolase C on Asp-319.

1 reference

12 December 2020

Dictyostelium nucleoside diphosphate kinase highly homologous to Nm23 and Awd proteins involved in mammalian tumor metastasis and Drosophila development

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12 December 2020

Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells.

1 reference

12 December 2020

Site-directed mutation of Nm23-H1. Mutations lacking motility suppressive capacity upon transfection are deficient in histidine-dependent protein phosphotransferase pathways in vitro.

1 reference

12 December 2020

nm23 in ovarian cancer: correlation with clinical outcome and other clinicopathologic and biochemical prognostic parameters

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12 December 2020

Effects of cytokine-mediated modulation of nm23 expression on the invasion and metastatic behavior of B16F10 melanoma cells.

1 reference

12 December 2020

nm23-H1 suppresses invasion of oral squamous cell carcinoma-derived cell lines without modifying matrix metalloproteinase-2 and matrix metalloproteinase-9 expression

1 reference

12 December 2020

Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis

1 reference

12 December 2020

prune/Killer of prune: a conditional dominant lethal interaction in Drosophila

1 reference

12 December 2020

Structure-based mutational and functional analysis identify human NM23-H2 as a multifunctional enzyme

1 reference

12 December 2020

Individual characterisation of the metastatic capacity of human breast carcinoma

1 reference

12 December 2020

Phosphorylation of geranyl and farnesyl pyrophosphates by Nm23 proteins/nucleoside diphosphate kinases

1 reference

12 December 2020

Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23.

1 reference

12 December 2020

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

1 reference

12 December 2020

Conversion of GDP into GTP by nucleoside diphosphate kinase on the GTP-binding proteins

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12 December 2020

Inhibition of cell motility after nm23 transfection of human and murine tumor cells

1 reference

12 December 2020

KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation

1 reference

12 December 2020

Evidence for a novel gene associated with low tumor metastatic potential

1 reference

12 December 2020

Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization

1 reference

12 December 2020

Identity of a differentiation inhibiting factor for mouse myeloid leukemia cells with NM23/nucleoside diphosphate kinase

1 reference

12 December 2020

Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation

1 reference

12 December 2020

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

1 reference

12 December 2020

Identification of structural domains affecting transactivation potential of Nm23.

1 reference

12 December 2020

Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis

1 reference

12 December 2020

Elevation of breast carcinoma Nm23-H1 metastasis suppressor gene expression and reduced motility by DNA methylation inhibition

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12 December 2020

nm23 influences proliferation and differentiation of PC12 cells in response to nerve growth factor

1 reference

12 December 2020

Regulatory GTP-binding proteins (ADP-ribosylation factor, Gt, and RAS) are not activated directly by nucleoside diphosphate kinase

1 reference

12 December 2020

The relationship between nm23, angiogenesis, and the metastatic proclivity of node-negative breast cancer.

1 reference

12 December 2020

Copurification of vimentin, energy metabolism enzymes, and a MER5 homolog with nucleoside diphosphate kinase. Identification of tissue-specific interactions

1 reference

12 December 2020

Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement

1 reference

12 December 2020

Down-regulation of N-acetylglucosaminyltransferase V by tumorigenesis- or metastasis-suppressor gene and its relation to metastatic potential of human hepatocarcinoma cells

1 reference

12 December 2020

A human NDP-kinase B specifically binds single-stranded poly-pyrimidine sequences

1 reference

12 December 2020

Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway

1 reference

12 December 2020

Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma

1 reference

12 December 2020

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK.

1 reference

12 December 2020

A novel function for nucleoside diphosphate kinase in Drosophila

1 reference

12 December 2020

Phosphorylation of ATP-citrate lyase by nucleoside diphosphate kinase

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12 December 2020

DR-nm23 expression affects neuroblastoma cell differentiation, integrin expression, and adhesion characteristics

1 reference

12 December 2020

Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1

1 reference

12 December 2020

Cleavage of DNA by human NM23-H2/nucleoside diphosphate kinase involves formation of a covalent protein-DNA complex

1 reference

12 December 2020

Inhibition of nucleoside diphosphate kinase activity by in vitro phosphorylation by protein kinase CK2 Differential phosphorylation of NDP kinases in HeLa cells in culture

1 reference

12 December 2020

Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development

1 reference

12 December 2020

Glyceraldehyde-3-phosphate dehydrogenase and Nm23-H1/nucleoside diphosphate kinase A. Two old enzymes combine for the novel Nm23 protein phosphotransferase function

1 reference

12 December 2020

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

1 reference

12 December 2020

A novel serine/threonine-specific protein phosphotransferase activity of Nm23/nucleoside-diphosphate kinase

1 reference

12 December 2020

Overexpression of NM23-1 enhances responsiveness of IMR-32 human neuroblastoma cells to differentiation stimuli

1 reference

12 December 2020

Inhibitory activity of nm23-H1 on invasion and colonization of human prostate carcinoma cells is not mediated by its NDP kinase activity

1 reference

12 December 2020

Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: effects on tumor metastatic potential, colonization and enzymatic activity

1 reference

12 December 2020

Decreased expression of nucleoside diphosphate kinase alpha isoform, an nm23-H2 gene homolog, is associated with metastatic potential of rat mammary-adenocarcinoma cells

1 reference

12 December 2020

Nm23/nucleoside diphosphate kinase in human cancers

1 reference

12 December 2020

Downregulation of intracellular nm23-H1 prevents cisplatin-induced DNA damage in oesophageal cancer cells: possible association with Na(+), K(+)-ATPase

1 reference

12 December 2020

C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

1 reference

12 December 2020

Effects of all-trans retinoic acid and epidermal growth factor on the expression of nm23-H1 in human hepatocarcinoma cells

1 reference

12 December 2020

Developmental consequences of awdb3, a cell-autonomous lethal mutation of Drosophila induced by hybrid dysgenesis.

1 reference

12 December 2020

The association between nm23-H1 expression and survival in patients with esophageal squamous cell carcinoma

1 reference

12 December 2020

Nm23-transfected MDA-mB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH: A31P nuclear magnetic resonance study in vivo and in vitro

1 reference

12 December 2020

Two-component kinase-like activity of nm23 correlates with its motility-suppressing activity

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1022578000022

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Dimensions Publication ID

6 August 2017

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