Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity (Q35080490)

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English	Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity	scientific article

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10 March 2020

Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity (English)

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10 March 2020

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10 March 2020

Reinald Pamplona

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10 March 2020

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10 March 2020

José Gregório Cabrera Gomez

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Jose Gomez

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10 March 2020

author name string

Alexia Gómez

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10 March 2020

Ines Sánchez-Roman

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10 March 2020

Julia Cruces

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10 March 2020

Ianire Mate

5

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10 March 2020

Mónica Lopez-Torres

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10 March 2020

Manuel Portero-Otin

8

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10 March 2020

Monica De la Fuente

10

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10 March 2020

publication date

26 February 2014

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10 March 2020

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10 March 2020

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10 March 2020

3

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10 March 2020

551-560

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10 March 2020

Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts

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8 July 2018

Regulation of longevity and oxidative stress by nutritional interventions: role of methionine restriction.

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β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice.

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Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents

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β-blockade: benefits beyond blood pressure reduction?

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Relationship of electrophilic stress to aging

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The effect of sympathetic antagonists on the antidepressant action of alprazolam

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Review of the literature and suggestions for the design of rodent survival studies for the identification of compounds that increase health and life span

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Advanced lipoxidation end-products.

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8 July 2018

The β-blocker atenolol lowers the longevity-related degree of fatty acid unsaturation, decreases protein oxidative damage, and increases extracellular signal-regulated kinase signaling in the heart of C57BL/6 mice.

1 reference

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Ovariectomy, a model of menopause in rodents, causes a premature aging of the nervous and immune systems

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration

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Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids

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8 July 2018

Role of neuroimmunomodulation in aging

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Life and death: metabolic rate, membrane composition, and life span of animals.

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8 July 2018

Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction

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Should beta blockers remain first choice in the treatment of primary hypertension? A meta-analysis

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Minireview: the role of oxidative stress in relation to caloric restriction and longevity.

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8 July 2018

Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: a homeoviscous-longevity adaptation?

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Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals

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8 July 2018

Low fatty acid unsaturation protects against lipid peroxidation in liver mitochondria from long-lived species: the pigeon and human case.

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The biologic clock: the mitochondria?

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The effects of captopril vs atenolol on memory, information processing and mood: a double-blind crossover study

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Modification of the longevity-related degree of fatty acid unsaturation modulates oxidative damage to proteins and mitochondrial DNA in liver and brain

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Independent and additive effects of atenolol and methionine restriction on lowering rat heart mitochondria oxidative stress.

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Protein restriction without strong caloric restriction decreases mitochondrial oxygen radical production and oxidative DNA damage in rat liver.

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Beta1-adrenergic receptors on immune cells impair innate defenses against Listeria

1 reference

https://pubmed.ncbi.nlm.nih.gov/24612513

12 December 2020

based on heuristic

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Type 5 adenylyl cyclase disruption increases longevity and protects against stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/24612513

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Background pathology in BDF1 mice allowed to live out their life-span

1 reference

https://pubmed.ncbi.nlm.nih.gov/24612513

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/24612513

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes with ageing in several leukocyte functions of male and female rats

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The gene cluster hypothesis of aging and longevity

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12 December 2020

based on heuristic

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Identifiers

10.1111/ACEL.12205

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Europe PubMed Central

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10 March 2020

1 reference

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10 March 2020

1 reference

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10 March 2020

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